ID A0A8D2D1N1_SCIVU Unreviewed; 281 AA.
AC A0A8D2D1N1;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 17.
DE SubName: Full=ADRM1 26S proteasome ubiquitin receptor {ECO:0000313|Ensembl:ENSSVLP00005017883.1};
OS Sciurus vulgaris (Eurasian red squirrel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Sciurinae; Sciurini; Sciurus.
OX NCBI_TaxID=55149 {ECO:0000313|Ensembl:ENSSVLP00005017883.1, ECO:0000313|Proteomes:UP000694564};
RN [1] {ECO:0000313|Ensembl:ENSSVLP00005017883.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSSVLP00005017883.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ADRM1 family.
CC {ECO:0000256|ARBA:ARBA00009216}.
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DR AlphaFoldDB; A0A8D2D1N1; -.
DR Ensembl; ENSSVLT00005019901.1; ENSSVLP00005017883.1; ENSSVLG00005014343.1.
DR GeneTree; ENSGT00390000013839; -.
DR OrthoDB; 340431at2759; -.
DR Proteomes; UP000694564; Chromosome 7.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IEA:TreeGrafter.
DR GO; GO:0061133; F:endopeptidase activator activity; IEA:TreeGrafter.
DR GO; GO:0070628; F:proteasome binding; IEA:TreeGrafter.
DR CDD; cd13314; PH_Rpn13; 1.
DR FunFam; 1.10.2020.20:FF:000001; Proteasomal ubiquitin receptor ADRM1; 1.
DR Gene3D; 1.10.2020.20; -; 1.
DR Gene3D; 2.30.29.70; Proteasomal ubiquitin receptor Rpn13/ADRM1; 1.
DR InterPro; IPR044867; DEUBAD_dom.
DR InterPro; IPR006773; Rpn13/ADRM1.
DR InterPro; IPR044868; Rpn13/ADRM1_Pru.
DR InterPro; IPR038633; Rpn13/ADRM1_Pru_sf.
DR InterPro; IPR032368; RPN13_DEUBAD.
DR InterPro; IPR038108; RPN13_DEUBAD_sf.
DR PANTHER; PTHR12225; ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN; 1.
DR PANTHER; PTHR12225:SF0; PROTEASOMAL UBIQUITIN RECEPTOR ADRM1; 1.
DR Pfam; PF04683; Rpn13_ADRM1_Pru; 1.
DR Pfam; PF16550; RPN13_C; 1.
DR PROSITE; PS51916; DEUBAD; 1.
DR PROSITE; PS51917; PRU; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW Reference proteome {ECO:0000313|Proteomes:UP000694564}.
FT DOMAIN 18..118
FT /note="Pru"
FT /evidence="ECO:0000259|PROSITE:PS51917"
FT DOMAIN 140..265
FT /note="DEUBAD"
FT /evidence="ECO:0000259|PROSITE:PS51916"
FT REGION 254..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 281 AA; 30738 MW; B4F09DF6BC714FB9 CRC64;
MTTSGALFPS LVPGSRVFSN EYLVEFWARK MSLKGTTVTP DKRKGLVYIQ TSGTVEDNLI
IFPDDCEFKR MPQCPSRRMY VLKFKAGYKW LFFWMQEPKT DQDEEHSCWA LLGLLPAALP
GASTTSPSPV PSSGNGTSTA ASLTQSIQLS DLQSILATMN VPAGPGGSQQ MDLTSVLTPE
MMCLLPYLSF GESLPHTAEE IRSTLTSLQF QQALGMFSMA LASGQLGPLM CQFGLAAEAV
EATNKGDVEA FTKAMQNNAR PEQKEGDTKD KKDNKEYMSL D
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