ID A0A8D2E394_THEGE Unreviewed; 690 AA.
AC A0A8D2E394;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 20.
DE SubName: Full=Receptor tyrosine kinase like orphan receptor 2 {ECO:0000313|Ensembl:ENSTGEP00000002307.1};
GN Name=ROR2 {ECO:0000313|Ensembl:ENSTGEP00000002307.1};
OS Theropithecus gelada (Gelada baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Theropithecus.
OX NCBI_TaxID=9565 {ECO:0000313|Ensembl:ENSTGEP00000002307.1, ECO:0000313|Proteomes:UP000694411};
RN [1] {ECO:0000313|Ensembl:ENSTGEP00000002307.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Chiou K.L., Snyder-Mackler N.;
RT "Whole genome of Theropithecus gelada.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSTGEP00000002307.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSTGEP00000002307.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00121}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A8D2E394; -.
DR Ensembl; ENSTGET00000002866.1; ENSTGEP00000002307.1; ENSTGEG00000002030.1.
DR Proteomes; UP000694411; Chromosome 15.
DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR GO; GO:0043235; C:receptor complex; IEA:TreeGrafter.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0015026; F:coreceptor activity; IEA:UniProtKB-ARBA.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:TreeGrafter.
DR GO; GO:0017147; F:Wnt-protein binding; IEA:TreeGrafter.
DR GO; GO:0007169; P:cell surface receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd07468; CRD_TK_ROR2; 1.
DR CDD; cd00108; KR; 1.
DR CDD; cd05091; PTKc_Ror2; 1.
DR FunFam; 1.10.2000.10:FF:000002; Inactive tyrosine-protein kinase transmembrane receptor ROR1; 1.
DR FunFam; 1.10.510.10:FF:000116; inactive tyrosine-protein kinase transmembrane receptor ROR1; 1.
DR FunFam; 2.40.20.10:FF:000003; Inactive tyrosine-protein kinase transmembrane receptor ROR1; 1.
DR FunFam; 3.30.200.20:FF:000139; inactive tyrosine-protein kinase transmembrane receptor ROR1; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 3.30.200.20; Phosphorylase Kinase, domain 1; 1.
DR Gene3D; 2.40.20.10; Plasminogen Kringle 4; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000001; Kringle.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR018056; Kringle_CS.
DR InterPro; IPR038178; Kringle_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR050122; RTK.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR016247; Tyr_kinase_rcpt_ROR.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR PANTHER; PTHR24416:SF132; TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR2; 1.
DR Pfam; PF01392; Fz; 1.
DR Pfam; PF00051; Kringle; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PIRSF; PIRSF000624; TyrPK_TMrec_ROR; 1.
DR PRINTS; PR00018; KRINGLE.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00130; KR; 1.
DR SUPFAM; SSF57440; Kringle-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS00021; KRINGLE_1; 1.
DR PROSITE; PS50070; KRINGLE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRSR:PIRSR000624-
KW 2}; Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Kringle {ECO:0000256|ARBA:ARBA00022572, ECO:0000256|PROSITE-
KW ProRule:PRU00121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRSR:PIRSR000624-2};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000694411};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transferase {ECO:0000256|ARBA:ARBA00022777};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT TRANSMEM 263..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..163
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 175..254
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DOMAIN 333..606
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 618..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..639
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 475
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000624-1"
FT BINDING 339..347
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000624-2"
FT BINDING 367
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000624-2"
SQ SEQUENCE 690 AA; 77737 MW; 3F8F79C475D6B785 CRC64;
MKTITATGVL FVRLGPTHSP NHNFQDDYHE DGFCQPYRGI ACARFIGNRT IYVDSLQMQG
EIENRITAAF TMIGTSTHLS DQCSQFAIPS FCHFVFPLCD ARSRAPKPRE LCRDECEVLE
SDLCRQEYTI ARSNPLILMR LQLPKCEALP MPESPDAANC MRIGIPAERL GRYHQCYNGS
GTDYRGTAST TKSGHQCQPW ALQHPHSHHL SSADFPELGG GHAYCRNPGG QMEGPWCFTQ
NKNVRMELCD VPSCSPRDSS KMGILYILVP SIAIPLVIAC LFFLVCMCRN KQKTSASTPQ
RRQLMASPSQ DMEMPLINQH KQAKLKEISL SAVRFMEELG EDRFGKVYKG HLFGPAPGEQ
TQAVAIKTLK DKAEGPLREE FRHEAMLRAR LQHPNIVCLL GVVTKDQPLS MIFSYCSHGD
LHEFLVMRSP HSDVGSTDDD RTVKSALEPP DFVHLVAQIA AGMEYLSSHH VVHKDLATRN
VLVYDKLNVR ISDLGLFREV YAADYYKLLG NSLLPIRWMA PEAIMYGKFS IDSDIWSYGV
VLWEVFSYGL QPYCGYSNQD VVEMIRNRQV LPCPEDCPAW VYALMIECWN EFPSRRPRFK
DIHSRLRAWG NLSNYNSSAQ TSGASNTTQT SSLSTSPVSN AVRTRGSGRQ CWTMEMPNAL
LWHNVSRVGS CWCLPGLADF KDEATDFRVM
//
