ID A0A8D2EY46_THEGE Unreviewed; 189 AA.
AC A0A8D2EY46;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 21.
DE SubName: Full=Hes family bHLH transcription factor 4 {ECO:0000313|Ensembl:ENSTGEP00000012925.1};
GN Name=HES4 {ECO:0000313|Ensembl:ENSTGEP00000012925.1};
OS Theropithecus gelada (Gelada baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Theropithecus.
OX NCBI_TaxID=9565 {ECO:0000313|Ensembl:ENSTGEP00000012925.1, ECO:0000313|Proteomes:UP000694411};
RN [1] {ECO:0000313|Ensembl:ENSTGEP00000012925.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Chiou K.L., Snyder-Mackler N.;
RT "Whole genome of Theropithecus gelada.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSTGEP00000012925.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSTGEP00000012925.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A8D2EY46; -.
DR Ensembl; ENSTGET00000015540.1; ENSTGEP00000012925.1; ENSTGEG00000010530.1.
DR Proteomes; UP000694411; Chromosome 1.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 6.10.250.980; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR050370; HES_HEY.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR Pfam; PF07527; Hairy_orange; 1.
DR SMART; SM00511; ORANGE; 1.
DR SUPFAM; SSF158457; Orange domain-like; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000694411};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 78..111
FT /note="Orange"
FT /evidence="ECO:0000259|PROSITE:PS51054"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..45
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 189 AA; 19806 MW; B5910BE1D783B60E CRC64;
MAADTPGKPS ASPMAGAPAS ASRTPDKPRS AAEHRKSSRH SKLEKADILE MTVRHLRSLR
RVQVTAALSA DPAVLGKYRA GFHECLAEVN RFLADCEGVP ADVRSRLLGH LAACLRQLGP
SRRPASLPPA APAEAPAPEV YAGRPLLPSL GGPFPLLAPL LLPGLTGALP AAPRAGPQGQ
GGPWRPWLR
//
