ID A0A8D2GTQ7_UROPR Unreviewed; 579 AA.
AC A0A8D2GTQ7;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 10-JUN-2026, entry version 21.
DE SubName: Full=Synapsin III {ECO:0000313|Ensembl:ENSUPAP00010001663.1};
GN Name=SYN3 {ECO:0000313|Ensembl:ENSUPAP00010001663.1};
OS Urocitellus parryii (Arctic ground squirrel) (Spermophilus parryii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Urocitellus.
OX NCBI_TaxID=9999 {ECO:0000313|Ensembl:ENSUPAP00010001663.1, ECO:0000313|Proteomes:UP000694417};
RN [1] {ECO:0000313|Ensembl:ENSUPAP00010001663.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JAN-2026) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC vesicle {ECO:0000256|ARBA:ARBA00004234}.
CC -!- SIMILARITY: Belongs to the synapsin family.
CC {ECO:0000256|ARBA:ARBA00008243}.
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DR RefSeq; XP_026252494.1; XM_026396709.1.
DR Ensembl; ENSUPAT00010001938.1; ENSUPAP00010001663.1; ENSUPAG00010001394.1.
DR GeneTree; ENSGT00940000155415; -.
DR Proteomes; UP000694417; Unplaced.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR GO; GO:0030672; C:synaptic vesicle membrane; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0007269; P:neurotransmitter secretion; IEA:InterPro.
DR GO; GO:0097091; P:synaptic vesicle clustering; IEA:Ensembl.
DR FunFam; 3.30.1490.20:FF:000008; Synapsin I; 1.
DR FunFam; 3.30.470.20:FF:000042; Synapsin III; 1.
DR FunFam; 3.40.50.20:FF:000008; Synapsin III; 1.
DR Gene3D; 3.40.50.20; -; 1.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR001359; Synapsin.
DR InterPro; IPR020898; Synapsin_ATP-bd_dom.
DR InterPro; IPR019735; Synapsin_CS.
DR InterPro; IPR019736; Synapsin_P_site.
DR InterPro; IPR020897; Synapsin_pre-ATP-grasp_dom.
DR PANTHER; PTHR10841; SYNAPSIN; 1.
DR PANTHER; PTHR10841:SF27; SYNAPSIN-3; 1.
DR Pfam; PF02078; Synapsin; 1.
DR Pfam; PF02750; Synapsin_C; 1.
DR Pfam; PF10581; Synapsin_N; 1.
DR PRINTS; PR01368; SYNAPSIN.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR PROSITE; PS00415; SYNAPSIN_1; 1.
DR PROSITE; PS00416; SYNAPSIN_2; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000694417};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 89..190
FT /note="Synapsin pre-ATP-grasp"
FT /evidence="ECO:0000259|Pfam:PF02078"
FT DOMAIN 192..394
FT /note="Synapsin ATP-binding"
FT /evidence="ECO:0000259|Pfam:PF02750"
FT REGION 18..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 406..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..39
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..66
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..431
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..488
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..555
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 579 AA; 63203 MW; 3A4B91184330FA7B CRC64;
MNFLRRRLSD SSFVANLPNG YMTDLQRPDS STSSPASPAM ERRHPQPLAA SFSSPGSSLF
SSFSSAMKQT PQASPGLMEP PGPSTPVVQR PRILLVIDDA HTDWSKYFHG KRVNGEIEIR
VEQAEFSELN LAAYVTGGCM VDMQVVRNGT KVVRSFKPDF ILVRQHAYSM ALGEDYRSLV
IGLQYGGLPA VNSLYSVYNF CSKPWVFSQL IKIFHSLGPE KFPLVEQTFF PNHKPMLTAP
HFPVVIKLGH AHAGMGKIKV ENQHDYQDIT SVVAMAKTYA TTEAFIDSKY DIRIQKIGSN
YKAYMRTSIS GNWKANTGSA MLEQVAMTER YRLWVDSCSE MFGGLDICAV KAVHSKDGRD
YIIEVMDSSM PLIGEHVEED KQLMADLVVS KMSQFLMPGG TVPSPLKPWA PQIKPAKSPG
QGQLGPQLGQ PQPRPPPQGG PRPAQSPQTP RSGSPSQQRL SPQGQQPLSP QAGSPQQQRS
PGSPQLSRAS GGSSPNQASK PGTSLASQPR PPVQGRSTSQ QADESKKTAA PHPHLNKSQS
LTNSLSTSDA SQRGTPSEDE AKAETIRNLR KSFASLFSB
//
