ID A0A8D2J134_VARKO Unreviewed; 407 AA.
AC A0A8D2J134;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 18.
DE SubName: Full=Adhesion regulating molecule 1 {ECO:0000313|Ensembl:ENSVKKP00000005230.1};
GN Name=ADRM1 {ECO:0000313|Ensembl:ENSVKKP00000005230.1};
OS Varanus komodoensis (Komodo dragon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Anguimorpha; Paleoanguimorpha; Varanoidea; Varanidae; Varanus.
OX NCBI_TaxID=61221 {ECO:0000313|Ensembl:ENSVKKP00000005230.1, ECO:0000313|Proteomes:UP000694545};
RN [1] {ECO:0000313|Ensembl:ENSVKKP00000005230.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSVKKP00000005230.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ADRM1 family.
CC {ECO:0000256|ARBA:ARBA00009216}.
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DR RefSeq; XP_044311347.1; XM_044455412.1.
DR RefSeq; XP_044311348.1; XM_044455413.1.
DR RefSeq; XP_044311349.1; XM_044455414.1.
DR AlphaFoldDB; A0A8D2J134; -.
DR Ensembl; ENSVKKT00000005377.1; ENSVKKP00000005230.1; ENSVKKG00000003872.1.
DR GeneID; 123036282; -.
DR KEGG; vko:123036282; -.
DR CTD; 11047; -.
DR OMA; SNQRHFF; -.
DR OrthoDB; 340431at2759; -.
DR Proteomes; UP000694545; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IEA:TreeGrafter.
DR GO; GO:0061133; F:endopeptidase activator activity; IEA:TreeGrafter.
DR GO; GO:0070628; F:proteasome binding; IEA:TreeGrafter.
DR CDD; cd13314; PH_Rpn13; 1.
DR FunFam; 1.10.2020.20:FF:000001; Proteasomal ubiquitin receptor ADRM1; 1.
DR FunFam; 2.30.29.70:FF:000001; Proteasomal ubiquitin receptor ADRM1; 1.
DR Gene3D; 1.10.2020.20; -; 1.
DR Gene3D; 2.30.29.70; Proteasomal ubiquitin receptor Rpn13/ADRM1; 1.
DR InterPro; IPR044867; DEUBAD_dom.
DR InterPro; IPR006773; Rpn13/ADRM1.
DR InterPro; IPR044868; Rpn13/ADRM1_Pru.
DR InterPro; IPR038633; Rpn13/ADRM1_Pru_sf.
DR InterPro; IPR032368; RPN13_DEUBAD.
DR InterPro; IPR038108; RPN13_DEUBAD_sf.
DR PANTHER; PTHR12225; ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN; 1.
DR PANTHER; PTHR12225:SF0; PROTEASOMAL UBIQUITIN RECEPTOR ADRM1; 1.
DR Pfam; PF04683; Rpn13_ADRM1_Pru; 1.
DR Pfam; PF16550; RPN13_C; 1.
DR PROSITE; PS51916; DEUBAD; 1.
DR PROSITE; PS51917; PRU; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW Reference proteome {ECO:0000313|Proteomes:UP000694545}.
FT DOMAIN 17..130
FT /note="Pru"
FT /evidence="ECO:0000259|PROSITE:PS51917"
FT DOMAIN 278..391
FT /note="DEUBAD"
FT /evidence="ECO:0000259|PROSITE:PS51916"
FT REGION 193..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 380..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..398
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 407 AA; 42193 MW; EDC87492C21E0862 CRC64;
MSSGALFPSL VPGSRGSSSK YLVEFRAGKM SLKGSTVTPD KRKGLVYIQQ TDDSLIHFCW
KDRTSGNVED DLIIFPDDCE FKRVPQCTTG RVYVLKFKAG SKRLFFWMQE PKTEKDEEHC
RKVNEYLNNP PMPGALGGSG SGGHELSALG GEGGLQSLLG NMSHNQLMQL IGPTGLGGLG
GLGALTGPGL ASLLGSGGPP TSSSSSSSRS QSAAATPSSS ASSTRVTPAP AAPAAATAAA
TSPSPAPSSG NGTSAATSPT QPIQLSDLQT ILATMNVPAG AGGQQVDLSS VLTPEIMAPI
LANTEVQERL LPYLPSGESL PQTAEEIQNT LTSPQFQQAL SMFSAALASG QLGPLMSQFG
LPAEAVDAAN KGDVEAFAKA MQNNVKSDQK EGDSKEKKDE EEDMSLD
//
