ID A0A8D2MDS8_ZONAL Unreviewed; 913 AA.
AC A0A8D2MDS8;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 21.
DE SubName: Full=Signal peptide, CUB domain and EGF like domain containing 1 {ECO:0000313|Ensembl:ENSZALP00000005014.1};
GN Name=SCUBE1 {ECO:0000313|Ensembl:ENSZALP00000005014.1};
OS Zonotrichia albicollis (White-throated sparrow) (Fringilla albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Passerellidae; Zonotrichia.
OX NCBI_TaxID=44394 {ECO:0000313|Ensembl:ENSZALP00000005014.1, ECO:0000313|Proteomes:UP000694413};
RN [1] {ECO:0000313|Ensembl:ENSZALP00000005014.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSZALP00000005014.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A8D2MDS8; -.
DR Ensembl; ENSZALT00000007500.1; ENSZALP00000005014.1; ENSZALG00000003795.1.
DR Proteomes; UP000694413; Unassembled WGS sequence.
DR GO; GO:0009986; C:cell surface; IEA:TreeGrafter.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:TreeGrafter.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 2.
DR FunFam; 2.10.25.10:FF:000510; Signal peptide, CUB and EGF-like domain-containing protein 1; 1.
DR FunFam; 2.10.50.10:FF:000024; signal peptide, CUB and EGF-like domain-containing protein 1; 1.
DR FunFam; 2.10.25.10:FF:000032; signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1; 1.
DR FunFam; 2.10.50.10:FF:000002; signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1; 1.
DR FunFam; 2.10.50.10:FF:000006; Signal peptide, CUB domain and EGF like domain containing 3; 1.
DR FunFam; 2.10.25.10:FF:000028; Signal peptide, CUB domain and EGF-like domain-containing 2; 1.
DR FunFam; 2.10.25.10:FF:000030; Signal peptide, CUB domain and EGF-like domain-containing 2; 1.
DR FunFam; 2.10.25.10:FF:000035; Signal peptide, CUB domain and EGF-like domain-containing 2; 1.
DR FunFam; 2.60.120.290:FF:000002; Signal peptide, CUB domain and EGF-like domain-containing 2; 1.
DR FunFam; 2.10.25.10:FF:000124; Signal peptide, CUB domain and EGF-like domain-containing 3; 1.
DR FunFam; 2.10.25.10:FF:000161; Signal peptide, CUB domain and EGF-like domain-containing 3; 1.
DR FunFam; 2.10.25.10:FF:000008; Signal peptide, CUB domain, EGF-like 2; 2.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR000742; EGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR024731; NELL2-like_EGF.
DR InterPro; IPR049883; NOTCH1_EGF-like.
DR InterPro; IPR052071; SCUB_EGF-like_domain.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF4; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 3.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM01411; Ephrin_rec_like; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 5.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000694413};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..913
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5034739402"
FT DOMAIN 38..78
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 122..158
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 317..357
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 358..396
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 724..835
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 362..372
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 913 AA; 100768 MW; 57F5D2190E50FBD0 CRC64;
PGLGGCGCGF KGNIYPCCFV ALVSLLICPL GVPSMLPDVD ECAEATDDCH IDAICQNTPK
SYKCICKPGY KGEGKQCEDI DECENDFYNG GCVHECINIP GNYRCTCYDG FMLAHDGHNC
LDVDECLDNN GGCQQICVNT MGSYECQCKE GFFLSDNQHT CIHRSIEGMN CMNKDHGCAH
ICRETPKGGV ACECRPGFEL AKNQKDCKLT CNYGNGGCQH TCDDTDTGPV CGCHQKYALH
SDGRTCIEKD EAAIESSEYN TTSVADVDKR VKRRLLMETC AVNNGGCDRT CKDTATGVRC
SCPVGFTLQP DGKTCKDIDE CLVNNGGCDH FCRNTVGSFE CSCQKGYKLL TDERTCQDID
ECSFERTCDH TCINYPGSFE CLCHKGYTLY GLTHCGDIDE CSISNGSCDF GCLNTMGSYE
CVCPPGKKLH WNKKDCVEMV KCLPNAKPTP KAQLVCSKAG GIESCFLSCP SNTLFVPGCD
FFVIISHLDT CNIDCVRKRM EQKLQTAIKT LRKSINKQQF YIQFSGTEYE VAQKPAKATE
GHEACSTGQV LQDGKCVTCS TGTFYSGEQK QCVPCSPGTY QDTEGQLTCE PCPSNDGQGV
AGARNVSECG GQCSPGHYSS DGFKPCTVCP LGTYQPEPGR TLCFPCGGGL VTKYEGAVSF
QDCETKVHCS PGHYYNSTTH RCIRCPVGTY QPEFGQNYCI TCPGNTSTDF DGSTNVTHCK
NQHCGGELGD YTGYIESPNY PGDYPANVEC IWNINPPPKR RILIVVPEIF LPIEDECGDV
LVMRKTSPTS ITTYETCQTY ERPIAFTSRS RKLWIQFKSN EGNSGKGFQV PYVTYDEDYQ
QLIEDIVRDG RLYASENHQE ILKDKKLIKA LFDVLAHPQN YFKYTAQESK EMFPRSFIKL
LRSKVSRFLR PYK
//
