ID A0A8D2ND33_ZONAL Unreviewed; 599 AA.
AC A0A8D2ND33;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 20.
DE RecName: Full=ATP-binding cassette sub-family E member 1 {ECO:0000256|ARBA:ARBA00069435};
DE AltName: Full=RNase L inhibitor {ECO:0000256|ARBA:ARBA00081891};
DE AltName: Full=Ribonuclease 4 inhibitor {ECO:0000256|ARBA:ARBA00078674};
GN Name=ABCE1 {ECO:0000313|Ensembl:ENSZALP00000020615.1};
OS Zonotrichia albicollis (White-throated sparrow) (Fringilla albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Passerellidae; Zonotrichia.
OX NCBI_TaxID=44394 {ECO:0000313|Ensembl:ENSZALP00000020615.1, ECO:0000313|Proteomes:UP000694413};
RN [1] {ECO:0000313|Ensembl:ENSZALP00000020615.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSZALP00000020615.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=CTP + H2O = CDP + phosphate + H(+); Xref=Rhea:RHEA:29387,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37563,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58069;
CC Evidence={ECO:0000256|ARBA:ARBA00051233};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + phosphate + H(+); Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00048548};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UTP + H2O = UDP + phosphate + H(+); Xref=Rhea:RHEA:64900,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:46398, ChEBI:CHEBI:58223;
CC Evidence={ECO:0000256|ARBA:ARBA00052409};
CC -!- SUBUNIT: Interacts with PINK1. Interacts with CNOT4. Interacts with
CC PELO. Probably heterodimerizes with RNASEL; this interaction inhibits
CC RNASEL. {ECO:0000256|ARBA:ARBA00065921}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCE family.
CC {ECO:0000256|ARBA:ARBA00061689}.
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DR RefSeq; XP_074396909.1; XM_074540808.1.
DR RefSeq; XP_074396910.1; XM_074540809.1.
DR AlphaFoldDB; A0A8D2ND33; -.
DR Ensembl; ENSZALT00000026949.1; ENSZALP00000020615.1; ENSZALG00000016202.1.
DR GeneID; 102069938; -.
DR KEGG; zab:102069938; -.
DR CTD; 6059; -.
DR OrthoDB; 6593433at2759; -.
DR Proteomes; UP000694413; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-ARBA.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProtKB-ARBA.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-ARBA.
DR CDD; cd03236; ABC_RNaseL_inhibitor_domain1; 1.
DR CDD; cd03237; ABC_RNaseL_inhibitor_domain2; 1.
DR FunFam; 3.40.50.300:FF:000144; ATP-binding cassette sub-family E member 1; 1.
DR FunFam; 3.40.50.300:FF:000152; ATP-binding cassette, sub-family E, member 1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013283; RLI1.
DR InterPro; IPR034348; RLI_dom_1.
DR InterPro; IPR007209; RNaseL-inhib-like_metal-bd_dom.
DR NCBIfam; NF009945; PRK13409.1; 1.
DR PANTHER; PTHR19248; ATP-BINDING TRANSPORT PROTEIN-RELATED; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF00037; Fer4; 1.
DR Pfam; PF04068; Fer4_RLI; 1.
DR PRINTS; PR01868; ABCEFAMILY.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51379; 4FE4S_FER_2; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000694413}.
FT DOMAIN 46..75
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 79..315
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 342..562
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 599 AA; 67378 MW; 737BC62533DD8E51 CRC64;
MADKLTRIAI VNHDKCKPKK CRQECKKSCP VVRMGKLCIE VTSQNKIAWI SETLCIGCGI
CIKKCPFGAL SIVNLPSNLE KETTHRYCAN AFKLHRLPIP RPGEVLGLVG TNGIGKSTAL
KILAGKQKPN LGKYDDPPDW QEILTYFRGS ELQNYFTKIL EDDLKAIIKP QYVDQIPKAA
KGTVGSILDR KDETKTQTVV CQQLDLTHLK ERNVEDLSGG ELQRFACAVV CIQKADIFMF
DEPSSYLDVK QRLKAAITIR SLINPDRYII VVEHDLSVLD YLSDFICCLY GVPSAYGVVT
MPFSVREGIN IFLDGYVPTE NLRFRDASLV FKVAETANEE EVKKMCMYKY PGMKKKMGEF
ELSIVAGEFT DSEIMVMLGE NGTGKTTFIR MLAGRLTPDE GGEVPVLNVS YKPQKISPKS
TGSVRQLLHE KIRDAYTHPQ FVTDVMKPLQ IENIIDQEVQ TLSGGELQRV ALALCLGKPA
DVYLIDEPSA YLDSEQRLMA ARVIKRFILH AKKTAFVVEH DFIMATYLAD RVIVFDGIPS
KNTLANSPQT LLAGMNKFLS QLEITFRRDP NNYRPRINKL NSIKDVEQKK SGNYFFLDD
//
