ID   A0A8E0VF33_9TREM        Unreviewed;       717 AA.
AC   A0A8E0VF33;
DT   19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2022, sequence version 1.
DT   02-APR-2025, entry version 13.
DE   SubName: Full=Transient-receptor-potential protein {ECO:0000313|EMBL:KAA0184719.1};
GN   ORFNames=FBUS_00694 {ECO:0000313|EMBL:KAA0184719.1};
OS   Fasciolopsis buskii.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Plagiorchiida; Echinostomata; Echinostomatoidea; Fasciolidae;
OC   Fasciolopsis.
OX   NCBI_TaxID=27845 {ECO:0000313|EMBL:KAA0184719.1, ECO:0000313|Proteomes:UP000728185};
RN   [1] {ECO:0000313|EMBL:KAA0184719.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HT {ECO:0000313|EMBL:KAA0184719.1};
RC   TISSUE=Whole worm {ECO:0000313|EMBL:KAA0184719.1};
RA   Choi Y.-J.;
RT   "Annotation for the trematode Fasciolopsis buski.";
RL   Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KAA0184719.1}.
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DR   EMBL; LUCM01010957; KAA0184719.1; -; Genomic_DNA.
DR   OrthoDB; 2373987at2759; -.
DR   Proteomes; UP000728185; Unassembled WGS sequence.
DR   GO; GO:0034703; C:cation channel complex; IEA:TreeGrafter.
DR   GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:TreeGrafter.
DR   GO; GO:0015279; F:store-operated calcium channel activity; IEA:TreeGrafter.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IEA:TreeGrafter.
DR   GO; GO:0007338; P:single fertilization; IEA:TreeGrafter.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR   PANTHER; PTHR10117:SF80; TRANSIENT-RECEPTOR-POTENTIAL-LIKE PROTEIN; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   SMART; SM00248; ANK; 2.
DR   SMART; SM01420; TRP_2; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
PE   4: Predicted;
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Reference proteome {ECO:0000313|Proteomes:UP000728185};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          300..362
FT                   /note="Transient receptor ion channel"
FT                   /evidence="ECO:0000259|SMART:SM01420"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          59..112
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          519..571
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..20
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..76
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        519..528
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        545..554
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        558..571
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   717 AA;  79573 MW;  380C5AAD403CFE5F CRC64;
     MPRKGSRDSG PPSQSSNVTK SPRKSIVFEK ITRSLEAGKD VPIGALSLNR FRRLTTGSLY
     QPRSDMRKSS DGDFHPLSRS PLDPISSLLG LDGSGPNYET DGGDPNLHSP SIVSRGRRVK
     RYVRSAPSGF GADNYSTALG PLQEKHVLNP LERVFLEAAE RGDKSTLARC LGFKEKVNVN
     CVNMLGRTAI QIAVDNENIE LVELLLKQPG IKIGDALLYA IQEGVYRIVE MLIDHPSITK
     EMLGSAWTDR VDLVHTEEES HDFSSDISPV ILASVCNQFE ILQLLLNRGA RIEEPHKGSC
     SCVKCHRLLN EDPLKHTLQR INTYRALASP AWISLTSPDP ILTAFELSSE LLHLASKENE
     FKETFISLCE QCRKYACDLL DLCRGTGEVV AVLSKSNFSD SENSDSDDES DALVDQTIDP
     IQDPGNLCDN PVLPGARPGV GIRKDLSVSD SRPEIHDWRA LANRANGTKR KHVKSDLFYH
     RSVSSSQLRQ GVSLESQHTI SDELGDDLTA TSMSNLQKIG SNSKTSVDGS RYLHVPANQP
     GQRVSIRESR KTNDDDNSIN NKTKNANDLT RSSAKVILNQ TDSTSDDALT VGYSGATGPR
     PTIFCEPRKV SFDHESTDHI GSVQTDSNSR WNTSTLACCT CYPCCGCAKC RRKNPKMNNC
     KKSKIEVKEF CLFKLDRLKL AIKHEQKRTG FVFTKPRRDR VKYSTELFRK YLGEFIL
//