ID A0A8H3FRQ6_9LECA Unreviewed; 467 AA.
AC A0A8H3FRQ6;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 05-FEB-2025, entry version 12.
DE RecName: Full=2-dehydropantoate 2-reductase {ECO:0008006|Google:ProtNLM};
GN ORFNames=HETSPECPRED_007772 {ECO:0000313|EMBL:CAF9931016.1};
OS Heterodermia speciosa.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Lecanoromycetes;
OC OSLEUM clade; Lecanoromycetidae; Caliciales; Physciaceae; Heterodermia.
OX NCBI_TaxID=116794 {ECO:0000313|EMBL:CAF9931016.1, ECO:0000313|Proteomes:UP000664521};
RN [1] {ECO:0000313|EMBL:CAF9931016.1}
RP NUCLEOTIDE SEQUENCE.
RA Tagirdzhanova G.;
RL Submitted (MAR-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC {ECO:0000256|ARBA:ARBA00007870}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CAF9931016.1}.
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DR EMBL; CAJPDS010000057; CAF9931016.1; -; Genomic_DNA.
DR OrthoDB; 73846at2759; -.
DR Proteomes; UP000664521; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:TreeGrafter.
DR GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:TreeGrafter.
DR GO; GO:0050661; F:NADP binding; IEA:TreeGrafter.
DR Gene3D; 1.10.1040.10; N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR050838; Ketopantoate_reductase.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR013332; KPR_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43765:SF2; 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR PANTHER; PTHR43765; 2-DEHYDROPANTOATE 2-REDUCTASE-RELATED; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000664521}.
FT DOMAIN 183..274
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 310..443
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..20
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 467 AA; 52031 MW; 903D48837A751A2B CRC64;
MGTSLKMGTH VRTRTKKPSP QKRIHVFGVD AIGLLVAHSL AGIPNRPPIT FLTGSRSGFH
RSEESERRIE VVTDGISDAR SGFDIEYDHP YIETEPLYSS VGSSDPQIFD RVDTAERFRL
ADELNAVRAT SAPELVLPVE RSPVGEQTGA ADTALDASRD VMRNEAVLPD FEQGKGYSSS
SSDDQDFISN LIVSVPAIHL RCLRKIAHRL NKESVLLFLQ NGMGFIDKVN EQVFPDPQTR
PTYIVGVVSH IAARTKAYTV VHSGRGAIAL GVMPRGEPGP IHSLSTSARY LLRTITRTPV
LAAVAYDQMN ILQYRLERLA IDCVIHPLTA VIECRNGELL ANFHIARMMK LILAEISLVA
RSLPELQNVP NLQNRFDPGR LEFYVVSVAR RTSQDESQML QDIRAGRDTH IGFLNGYFIR
KGEELGIRCV MNYMLKQMVQ AKQRSVSNRD FERLPMESQD SLVLAGR
//
