ID   A0A8H4NT80_9HYPO        Unreviewed;       521 AA.
AC   A0A8H4NT80;
DT   19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2022, sequence version 1.
DT   28-JAN-2026, entry version 15.
DE   RecName: Full=sphingolipid C(9)-methyltransferase {ECO:0000256|ARBA:ARBA00039020};
DE            EC=2.1.1.317 {ECO:0000256|ARBA:ARBA00039020};
GN   ORFNames=FACUT_5642 {ECO:0000313|EMBL:KAF4437552.1};
OS   Fusarium acutatum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium fujikuroi species complex.
OX   NCBI_TaxID=78861 {ECO:0000313|EMBL:KAF4437552.1, ECO:0000313|Proteomes:UP000536711};
RN   [1] {ECO:0000313|EMBL:KAF4437552.1, ECO:0000313|Proteomes:UP000536711}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 13308 {ECO:0000313|EMBL:KAF4437552.1,
RC   ECO:0000313|Proteomes:UP000536711};
RA   Kim H.-S., Busman M., Brown D.W., Divon H., Uhlig S., Proctor R.H.;
RT   "Identification and distribution of gene clusters putatively required for
RT   synthesis of sphingolipid metabolism inhibitors in phylogenetically diverse
RT   species of the filamentous fungus Fusarium.";
RL   Submitted (JAN-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Lipid metabolism; sphingolipid metabolism.
CC       {ECO:0000256|ARBA:ARBA00004760}.
CC   -!- PATHWAY: Sphingolipid metabolism. {ECO:0000256|ARBA:ARBA00004991}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the CFA/CMAS family.
CC       {ECO:0000256|ARBA:ARBA00010815}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KAF4437552.1}.
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DR   EMBL; JAADJF010000128; KAF4437552.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A8H4NT80; -.
DR   OrthoDB; 412182at2759; -.
DR   Proteomes; UP000536711; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR052290; Sphingo_C9-MT.
DR   PANTHER; PTHR45197:SF1; SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED; 1.
DR   PANTHER; PTHR45197; SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED; 1.
DR   Pfam; PF02353; CMAS; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   3: Inferred from homology;
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000536711};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        56..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        84..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   521 AA;  59708 MW;  C88D91325E36077A CRC64;
     MAEKSGVTGA DFEFVKTPPY PKPDFDKLED VGVPTTRYPA IKNAPLPADG SGADTFNNYV
     LVSILVAVPW FLSRKVGGGL KTTIFFALIV DLPLLAAWWL VISSISPRKN EKVRLPNRGV
     EHYLEFKKEA DRLKYRGSNK IPMETFHEMY FDGDVDFKGD CLEIMEYRHD WASFRFTIGL
     IKFFLFGMIP EVIMHTRSQD EEQVRDHYDR GDDFYGWFLG PRMIYTSGII SDINREETLE
     ELQDNKLTVV CEKIGLNKGD SMLDIGCGWG TLARFASEQY GAHVTGVTLG RNQTAWGNSS
     MRKAGIPEEQ SKILCMDYRD IPVPEGGYKK ITSLEMSEHV GIRHFGSFLK QVHDMLDDDG
     VFFLQYAGLR KAWQYEDFTW GLFMNKYIFP GADASTPLGW VVDKLEGTGF EIKHIDTIGV
     HYSATLWRWY RNWMSNRDKV EAKYGKRWFR IWEYFLAYST IISRQGSATC FQITLVKNIN
     STHRVEGIET QFAITGALDN CRADLQSWAS RNNVKTPSEY L
//