ID A0A8H5JAK4_9HYPO Unreviewed; 502 AA.
AC A0A8H5JAK4;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 15.
DE SubName: Full=Sphingosine kinase {ECO:0000313|EMBL:KAF5550505.1};
GN ORFNames=FNAPI_7708 {ECO:0000313|EMBL:KAF5550505.1};
OS Fusarium napiforme.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium fujikuroi species complex.
OX NCBI_TaxID=42672 {ECO:0000313|EMBL:KAF5550505.1, ECO:0000313|Proteomes:UP000574317};
RN [1] {ECO:0000313|EMBL:KAF5550505.1, ECO:0000313|Proteomes:UP000574317}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 25196 {ECO:0000313|EMBL:KAF5550505.1,
RC ECO:0000313|Proteomes:UP000574317};
RA Kim H.-S., Busman M., Brown D.W., Divon H., Uhlig S., Proctor R.H.;
RT "Identification and distribution of gene clusters putatively required for
RT synthesis of sphingolipid metabolism inhibitors in phylogenetically diverse
RT species of the filamentous fungus Fusarium.";
RL Submitted (MAY-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF5550505.1}.
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DR EMBL; JAAOAO010000284; KAF5550505.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A8H5JAK4; -.
DR Proteomes; UP000574317; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0016020; C:membrane; IEA:TreeGrafter.
DR GO; GO:0001727; F:lipid kinase activity; IEA:TreeGrafter.
DR GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:UniProtKB-ARBA.
DR GO; GO:0046512; P:sphingosine biosynthetic process; IEA:TreeGrafter.
DR Gene3D; 2.60.200.40; -; 1.
DR Gene3D; 3.40.50.10330; Probable inorganic polyphosphate/atp-NAD kinase, domain 1; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR055916; DUF7493.
DR InterPro; IPR050187; Lipid_Phosphate_FormReg.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR PANTHER; PTHR12358:SF31; ACYLGLYCEROL KINASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR Pfam; PF24321; DUF7493; 1.
DR SMART; SM00046; DAGKc; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:KAF5550505.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000574317};
KW Transferase {ECO:0000313|EMBL:KAF5550505.1}.
FT DOMAIN 117..256
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
SQ SEQUENCE 502 AA; 54965 MW; 4F05A07E6CAF6983 CRC64;
MDEGIGMLLL LEGKKKLTIG IEELELNDPA ANKSTRSSCA PFSGKPGPNH SIPFYNVLWA
ELSNDQIIID YAYHASKTLI KPKKWVFTLA KDDESTSGTP AEIFVKTLMT RAYGDAQSQK
RAYVLINPNS GPGGAIKQWE TEVKPLFQAA KMQIDPVILK HGGEAVELAQ NADLSRYDTI
MACSGDGTPH EIFNGLAKRP DAARALSTMP VSHIPCGSGN AFSCNLYGSH RPSFAALAII
KGVVTPMDLV SVTSGHNRII SFLSQTLGLI AECDLGTEHM RWMGSARFEV GVVQRMFKKK
CYPFDLAVKV EIEDKGDVKA HYKHHASSTS LNHLAKKLDV DPVAEDAGLP PLKYGTIQDD
LPEGWELIPY DKVGTFYAGN MAYMSPDAPF FAASLISDGL MDLVTIDGDL PFFTAIKVLL
DVEAEKLFDN PHVTYKKISA YRIIPRDQED GYISIDGEKC PFGPFQAEIH QGLGRVISKS
GKYEAAGPKN WDKVTLADRI HG
//
