ID   A0A8H5KZ13_9HYPO        Unreviewed;       707 AA.
AC   A0A8H5KZ13;
DT   19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2022, sequence version 1.
DT   02-APR-2025, entry version 14.
DE   RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE            EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN   ORFNames=FPCIR_10189 {ECO:0000313|EMBL:KAF5581388.1};
OS   Fusarium pseudocircinatum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium fujikuroi species complex.
OX   NCBI_TaxID=56676 {ECO:0000313|EMBL:KAF5581388.1, ECO:0000313|Proteomes:UP000546213};
RN   [1] {ECO:0000313|EMBL:KAF5581388.1, ECO:0000313|Proteomes:UP000546213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 36939 {ECO:0000313|EMBL:KAF5581388.1,
RC   ECO:0000313|Proteomes:UP000546213};
RA   Kim H.-S., Busman M., Brown D.W., Divon H., Uhlig S., Proctor R.H.;
RT   "Identification and distribution of gene clusters putatively required for
RT   synthesis of sphingolipid metabolism inhibitors in phylogenetically diverse
RT   species of the filamentous fungus Fusarium.";
RL   Submitted (MAY-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC         EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KAF5581388.1}.
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DR   EMBL; JAAOAS010000292; KAF5581388.1; -; Genomic_DNA.
DR   OrthoDB; 9977870at2759; -.
DR   Proteomes; UP000546213; Unassembled WGS sequence.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR   CDD; cd20335; BRcat_RBR; 1.
DR   CDD; cd22584; Rcat_RBR_unk; 1.
DR   Gene3D; 1.20.120.1750; -; 1.
DR   InterPro; IPR031127; E3_UB_ligase_RBR.
DR   InterPro; IPR002867; IBR_dom.
DR   InterPro; IPR044066; TRIAD_supradom.
DR   PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR   Pfam; PF01485; IBR; 2.
DR   SMART; SM00647; IBR; 2.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS51873; TRIAD; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000546213};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          215..406
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51873"
FT   REGION          91..114
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          443..480
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        91..113
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   707 AA;  82245 MW;  DCD224A7C2389491 CRC64;
     MPGAFGPEDY IDFYEGPFEV FNGSEASGEK QEQRGSWAVK KLPDLDIVDL DWHKYSPPKA
     LRKAPNITSQ VLLDVLQSSV ENVSARIIEE DRQKKENEEQ RKQEENEKGK SKEPYLPIII
     PTEPPVEEKT NHAVPLPNIK KEILMTTFGP SVVTQADARA NKRRLFALRR FFQRSDERGE
     SSATGAALGA LQERVAEAEH VNESLGRLTK PNSVEEVECV SCLDDFHPKD VIKVPCHYYC
     RDCFVRLVTA ACQNEQQWPP KCCLNEIPVK TIIRFIPSGL KKTFEDRSKE WELPVSDRVY
     CSNPNCHLWI KPKRIYPGKR QGICDRSHVT CTLCRGPAHA GEDCPQDVDM SLTNQLAEDE
     GWKRCFNCNA LVEHREACQH MTCRCGTQFC YVCSRRWRTC TCTMEDLQAL KGGVVSRRAE
     RRAHELEEAE ELRHILLQIE EFEREEALKA ELLRLEQERL EEERRQRELE ERVRQESIRR
     RDIEVKYQEL RTVLDELHDL QQVLLDVDQE EEAENMIIDI RAAKQELEIK HETEVSELKA
     LALAKMTEKE NSLNNDFRVR AAKENELEEA YHERLKAYWE GKDSGDQEVE NSMLALRKRM
     DQKHHVWQKW KADQLKVLEA KLEDNRTYRE ELMYSAKHRL DDSCKEKEAE MMRRMAAEKK
     WLEAVILERE KLLNEREAQE VEGDANSMFA VESVDSANGH YVIATTF
//