ID A0A8H5WY50_FUSHE Unreviewed; 510 AA.
AC A0A8H5WY50;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 15.
DE SubName: Full=Sphingosine kinase {ECO:0000313|EMBL:KAF5674299.1};
GN ORFNames=FHETE_2933 {ECO:0000313|EMBL:KAF5674299.1};
OS Fusarium heterosporum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium heterosporum species complex.
OX NCBI_TaxID=42747 {ECO:0000313|EMBL:KAF5674299.1, ECO:0000313|Proteomes:UP000567885};
RN [1] {ECO:0000313|EMBL:KAF5674299.1, ECO:0000313|Proteomes:UP000567885}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 20693 {ECO:0000313|EMBL:KAF5674299.1,
RC ECO:0000313|Proteomes:UP000567885};
RA Kim H.-S., Busman M., Brown D.W., Divon H., Uhlig S., Proctor R.H.;
RT "Identification and distribution of gene clusters putatively required for
RT synthesis of sphingolipid metabolism inhibitors in phylogenetically diverse
RT species of the filamentous fungus Fusarium.";
RL Submitted (MAY-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF5674299.1}.
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DR EMBL; JAAGWQ010000048; KAF5674299.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A8H5WY50; -.
DR OrthoDB; 3853857at2759; -.
DR Proteomes; UP000567885; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0016020; C:membrane; IEA:TreeGrafter.
DR GO; GO:0001727; F:lipid kinase activity; IEA:TreeGrafter.
DR GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:UniProtKB-ARBA.
DR GO; GO:0046512; P:sphingosine biosynthetic process; IEA:TreeGrafter.
DR Gene3D; 2.60.200.40; -; 1.
DR Gene3D; 3.40.50.10330; Probable inorganic polyphosphate/atp-NAD kinase, domain 1; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR055916; DUF7493.
DR InterPro; IPR050187; Lipid_Phosphate_FormReg.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR PANTHER; PTHR12358:SF31; ACYLGLYCEROL KINASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR Pfam; PF24321; DUF7493; 1.
DR SMART; SM00046; DAGKc; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:KAF5674299.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000567885};
KW Transferase {ECO:0000313|EMBL:KAF5674299.1}.
FT DOMAIN 125..264
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
SQ SEQUENCE 510 AA; 55381 MW; F8AB51C317DCD9F3 CRC64;
MTTEADRNME DGVGMQLLLE GSRKLTIGTD GLELNDPATK KSNRSSCAPF GGAGSTKNTI
PFYNVLWAEL SDNRITIDYA IHVSKTLIKP GKWNYTLALD DESANEPPAE NFVKTLLSRA
YGDAPPAKRA YVLINPNSGP GGAVRQWENE VKPLFDAAKM QLDVVILKHG GEAVELAQNA
DLSRYDTIMA CSGDGTPHEI FNGLAKRPDA ARALATMPVS HIPCGSGNAF SCNLYGSHRP
SFAALAIIKG IVTPMDLVSV TSGNNRIISF LSQTLGLIAE CDLGTEHMRW MGSARFEVGV
VQRMFKKKCY PFDLAVKVEI EDKNDVKAHY KHHASTTSLA QLAKSAEAGS MADDAGLPKL
KYGTIQDDLP EGWELIPYNK IGTFYAGNMA YMSPDAPFFA ASLISDGLMD LVTIDGDLPF
LTAIGVLLDV EAEKLFDNPH VTYKKISAYR IIPRDQKDGY ISIDGEKCPF GPFQAEIHQG
LGRVISKAGK YEASGPKGWD KVTLADRIHG
//
