ID A0A8H7TMW4_9HELO Unreviewed; 536 AA.
AC A0A8H7TMW4;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 13.
DE RecName: Full=Glucanase {ECO:0000256|RuleBase:RU361164};
DE EC=3.2.1.- {ECO:0000256|RuleBase:RU361164};
GN ORFNames=IFR04_005139 {ECO:0000313|EMBL:KAG4421763.1};
OS Cadophora malorum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Ploettnerulaceae; Cadophora.
OX NCBI_TaxID=108018 {ECO:0000313|EMBL:KAG4421763.1, ECO:0000313|Proteomes:UP000664132};
RN [1] {ECO:0000313|EMBL:KAG4421763.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=M34 {ECO:0000313|EMBL:KAG4421763.1};
RA Stefanovic E., Vu D., Scully C., Dijksterhuis J., Roader J., Houbraken J.;
RT "Genome sequence Cadophora malorum strain M34.";
RL Submitted (FEB-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose
CC and cellotetraose, releasing cellobiose from the non-reducing ends of
CC the chains.; EC=3.2.1.91; Evidence={ECO:0000256|ARBA:ARBA00001641};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 7 (cellulase C) family.
CC {ECO:0000256|ARBA:ARBA00006044, ECO:0000256|RuleBase:RU361164}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAG4421763.1}.
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DR EMBL; JAFJYH010000060; KAG4421763.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A8H7TMW4; -.
DR OrthoDB; 412382at2759; -.
DR Proteomes; UP000664132; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0016162; F:cellulose 1,4-beta-cellobiosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030248; F:cellulose binding; IEA:InterPro.
DR GO; GO:0030245; P:cellulose catabolic process; IEA:UniProtKB-KW.
DR CDD; cd07999; GH7_CBH_EG; 1.
DR FunFam; 2.70.100.10:FF:000001; Glucanase; 1.
DR Gene3D; 2.70.100.10; Glycoside hydrolase, family 7, domain; 1.
DR InterPro; IPR000254; CBD.
DR InterPro; IPR035971; CBD_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001722; Glyco_hydro_7.
DR InterPro; IPR037019; Glyco_hydro_7_sf.
DR PANTHER; PTHR33753; 1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B; 1.
DR PANTHER; PTHR33753:SF2; GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN; 1.
DR Pfam; PF00734; CBM_1; 1.
DR Pfam; PF00840; Glyco_hydro_7; 1.
DR PRINTS; PR00734; GLHYDRLASE7.
DR SMART; SM00236; fCBD; 1.
DR SUPFAM; SSF57180; Cellulose-binding domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS00562; CBM1_1; 1.
DR PROSITE; PS51164; CBM1_2; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Cellulose degradation {ECO:0000256|ARBA:ARBA00023001,
KW ECO:0000256|RuleBase:RU361164};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361164};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361164};
KW Polysaccharide degradation {ECO:0000256|ARBA:ARBA00023326,
KW ECO:0000256|RuleBase:RU361164};
KW Reference proteome {ECO:0000313|Proteomes:UP000664132};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..536
FT /note="Glucanase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5034655656"
FT DOMAIN 500..536
FT /note="CBM1"
FT /evidence="ECO:0000259|PROSITE:PS51164"
FT REGION 460..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..502
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 536 AA; 56317 MW; 785CA41092CB6F83 CRC64;
MSSRIALASL LLSVASGQGI GTLTPEVHPP LTWQTCTAYG SCTTIAGKVV LDSNWRWLHS
STGTNCYTGN TWNPTFCPDN VSCAQNCQLD GADYSGTYGA TTTGNALRLN FVTNGANRNV
GSRMFLMADD SNYQMLTLLN REFTFDVDVS HLPCGLNGAL YLISMAKDGG ASLYPNNKAG
AKYGVGYCDA QCPRDLKFIN GEANVEGWVP ASNNANTGFG THGSCCAEMD IWEANSISTA
FTPHSSDPTG QTMCSGDACG GTYSSDRYAG VTDPDGCDFN SFRQGNKEFY GPGKTVNTNS
VFTVVTQFLT NTGTDSGTLS EIKRFYVQNG VVIPNSQSTI AGNPGNSLTD SFCKAQKTVF
GDQDIYNLHG GFASMSKALK DGMVLSLSLW DDYAANMLWL DSNYPVDADP AKPGIARGSC
PTTSGVPADV EAAHPDAYVI YSNIKVGAIN STFNAGSVVN PPTGGSSSST RATSSTTLRT
STTSTRTTTS AATTSSAASG GAARWGQCGG IGFTGPTTCQ SPWTCTYSSP YYSQCL
//
