ID A0A8I3NTI3_CANLF Unreviewed; 565 AA.
AC A0A8I3NTI3;
DT 25-MAY-2022, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 1.
DT 28-JAN-2026, entry version 19.
DE RecName: Full=Deformed epidermal autoregulatory factor 1 homolog {ECO:0000256|ARBA:ARBA00073412};
DE AltName: Full=Nuclear DEAF-1-related transcriptional regulator {ECO:0000256|ARBA:ARBA00079052};
GN Name=DEAF1 {ECO:0000313|Ensembl:ENSCAFP00845024233.1};
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00845024233.1, ECO:0000313|Proteomes:UP000805418};
RN [1] {ECO:0000313|Ensembl:ENSCAFP00845024233.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Labrador retriever {ECO:0000313|Ensembl:ENSCAFP00845024233.1};
RA Eory L., Zhang W., Schoenebeck J.;
RT "Long-read based genome assembly of a Labrador retriever dog.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCAFP00845024233.1}
RP IDENTIFICATION.
RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00845024233.1};
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSCAFP00845024233.1}
RP IDENTIFICATION.
RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00845024233.1};
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_038279965.1; XM_038424037.1.
DR RefSeq; XP_038418886.1; XM_038562958.1.
DR RefSeq; XP_540529.2; XM_540529.6.
DR AlphaFoldDB; A0A8I3NTI3; -.
DR Ensembl; ENSCAFT00845030922.1; ENSCAFP00845024233.1; ENSCAFG00845017450.1.
DR GeneID; 483409; -.
DR CTD; 10522; -.
DR GeneTree; ENSGT00940000159701; -.
DR OMA; KDHQHSC; -.
DR OrthoDB; 437457at2759; -.
DR Proteomes; UP000805418; Chromosome 18.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:UniProtKB-ARBA.
DR FunFam; 3.10.390.10:FF:000004; Deformed epidermal autoregulatory factor 1; 1.
DR FunFam; 6.10.140.2220:FF:000008; Deformed epidermal autoregulatory factor 1; 1.
DR Gene3D; 6.10.140.2220; -; 1.
DR Gene3D; 3.10.390.10; SAND domain-like; 1.
DR InterPro; IPR010919; SAND-like_dom_sf.
DR InterPro; IPR000770; SAND_dom.
DR InterPro; IPR024119; TF_DEAF-1.
DR InterPro; IPR002893; Znf_MYND.
DR PANTHER; PTHR10237:SF1; DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG; 1.
DR PANTHER; PTHR10237; DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN; 1.
DR Pfam; PF01342; SAND; 1.
DR Pfam; PF01753; zf-MYND; 1.
DR SMART; SM00258; SAND; 1.
DR SUPFAM; SSF144232; HIT/MYND zinc finger-like; 1.
DR SUPFAM; SSF63763; SAND domain-like; 1.
DR PROSITE; PS50864; SAND; 1.
DR PROSITE; PS01360; ZF_MYND_1; 1.
DR PROSITE; PS50865; ZF_MYND_2; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000805418};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00134}.
FT DOMAIN 193..273
FT /note="SAND"
FT /evidence="ECO:0000259|PROSITE:PS50864"
FT DOMAIN 504..540
FT /note="MYND-type"
FT /evidence="ECO:0000259|PROSITE:PS50865"
FT REGION 34..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 162..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 565 AA; 59240 MW; C50BE26A8156D958 CRC64;
MEDSDSAAKQ LGLAEAAAVA AAAAVAAAAA AAAGGEAEEP VLSRDEDSEE DGDSEAERET
RRVTAVAVMA AEPGHMDMGA EALPGPDEAA AAAAFAEVTT VTVANVGASA DNVFTTSVAN
AASLSGHVLS GRTALQIGDS LNTEKATLIV VHTDGSIVET SGLKGPAAPL TPGPQCPASP
AAPGQDRGGT KYNWDPSVYD SELPVRCRNI SGTLFKSRLG SGGRGRCIKQ GENWYSPTEF
EAMAGRASSK DWKRSIRYAG RPLQCLIQDG ILNPHAASCT CAACCDDMTL SGPVRLFVPY
KRRKKENELP TTPVKKEPPK NITLLPATAA TAFTVTPSGQ ITTSGALTFD RASTVEATAV
ISESPAQGDV FAGATVQEAG VQPPCRVGHP EPHYPGYQDS CQIAPFPEAA LPTSHPKIVL
TSLPALAVPP STPTKAVSPA VVNGLEMSEQ RSWLYLEEMV NSLLSTAQQL KTLFEQAKQA
SSYREAAVAQ ARVQADTERK EQSCVNCGRE ALSECTGCHK VNYCSTFCQR KDWKDHQHMC
GQSAAVTVQA DEVHVTDSVM EKVTV
//
