ID A0A8I3P283_CANLF Unreviewed; 857 AA.
AC A0A8I3P283;
DT 25-MAY-2022, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 1.
DT 28-JAN-2026, entry version 20.
DE SubName: Full=Zinc finger protein 598, E3 ubiquitin ligase {ECO:0000313|Ensembl:ENSCAFP00845024092.1};
GN Name=ZNF598 {ECO:0000313|Ensembl:ENSCAFP00845024092.1};
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00845024092.1, ECO:0000313|Proteomes:UP000805418};
RN [1] {ECO:0000313|Ensembl:ENSCAFP00845024092.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Labrador retriever {ECO:0000313|Ensembl:ENSCAFP00845024092.1};
RA Eory L., Zhang W., Schoenebeck J.;
RT "Long-read based genome assembly of a Labrador retriever dog.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCAFP00845024092.1}
RP IDENTIFICATION.
RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00845024092.1};
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSCAFP00845024092.1}
RP IDENTIFICATION.
RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00845024092.1};
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
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DR AlphaFoldDB; A0A8I3P283; -.
DR FunCoup; A0A8I3P283; 1051.
DR Ensembl; ENSCAFT00845030713.1; ENSCAFP00845024092.1; ENSCAFG00845017173.1.
DR GeneTree; ENSGT00390000014178; -.
DR OrthoDB; 3838338at2759; -.
DR Proteomes; UP000805418; Chromosome 6.
DR GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0072344; P:rescue of stalled ribosome; IBA:GO_Central.
DR InterPro; IPR057634; PAH_ZNF598/HEL2.
DR InterPro; IPR044288; ZNF598/HEL2.
DR InterPro; IPR059042; Znf_C2H2_ZNF598.
DR PANTHER; PTHR22938:SF0; E3 UBIQUITIN-PROTEIN LIGASE ZNF598; 1.
DR PANTHER; PTHR22938; ZINC FINGER PROTEIN 598; 1.
DR Pfam; PF23202; PAH_ZNF598; 1.
DR Pfam; PF25447; RING_ZNF598; 1.
DR Pfam; PF23208; zf_C2H2_ZNF598; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000805418}.
FT DOMAIN 722..799
FT /note="ZNF598/HEL2 PAH"
FT /evidence="ECO:0000259|Pfam:PF23202"
FT DOMAIN 825..847
FT /note="ZNF598 C2H2 zinc finger"
FT /evidence="ECO:0000259|Pfam:PF23208"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 254..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 798..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..12
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..264
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..325
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..354
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..399
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..426
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 498..507
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..628
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 811..820
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 857 AA; 91591 MW; 490B21A040CD207C CRC64;
RAAPAGNAGR PALEARGTAA PERGGGSCVL CCGGTCESTP GVAAAAVTKR RAAVFFCEQR
TTAPCRWEIP LVVRGKLGSF MHLTHLASHQ LQHEKKYDIY FADGKFPLSW DRLGVEGCRT
CKPLAPFSLP DIHCLFFFVD ERKWYRSVIW YSWTPLRHRR ARGRLRRTSH TVRTHSKVVT
SSSYLTIEQK CSKSDRADDH YFCHFCDSDG AQDYYSNSEE ACVLCEEGRC SSEQFTHAFR
TEIDLKAHRT ACHSRSRAKA RQKRPQIDLC TASATPRGTR AGARVSQQGR RTASGRGAQQ
SRRGEDVAAA IRASVAAQQQ QQPQQETRKS EDREEGGRPK KEEAGLRGLE ELRGPRRPAR
TQGEGPGLKE ASPNDPVSQE GLPTTSPATG ATLPSTLPAP SSKLKDEDFP SLCASTSSSS
SSAAAALGPS GLALAYPVPA RGRSAFQEDD FPALVSASKP STAPTSLISA WNSSGNKKVA
HPSAGAQAAG GSTQPPRKAG KGAKGGRKGG PVPSEEEEED GRSGLTAQEL RSVPTTVAVS
SLLALASTQT VTKVGKKKKV GSEKPGATSP PLPLPDRDGP LGAEQAPATT TGRAEGPVAL
IVNGHTEGPA PARSTPKEPP GLPRPLGPLP CPPAQEDFPA LGVPCPPRMP PPPGFNAVVL
LKGTPPPPPP GLVPPVSKPP PGFSGLLPSP HPACVPSTAT TTKAPRLTPA PQAYLVPENF
RERNLQLIQS IKDFLQSDEA RFGQFKSHSG EFRQGMISAA QYYKSCRDLL GENFQKIFNE
LLVLLPDTAK QQELLSAHTH FRGQERPPGT KAKKSKKRGA HGRLQVLAHG DVSSHQALHA
AQDNDFPSLQ AIARILT
//
