ID   A0A8I3PKF5_CANLF        Unreviewed;       757 AA.
AC   A0A8I3PKF5;
DT   25-MAY-2022, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 1.
DT   10-JUN-2026, entry version 20.
DE   SubName: Full=Progesterone immunomodulatory binding factor 1 {ECO:0000313|Ensembl:ENSCAFP00845031739.1};
GN   Name=PIBF1 {ECO:0000313|Ensembl:ENSCAFP00845031739.1};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00845031739.1, ECO:0000313|Proteomes:UP000805418};
RN   [1] {ECO:0000313|Ensembl:ENSCAFP00845031739.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Labrador retriever {ECO:0000313|Ensembl:ENSCAFP00845031739.1};
RA   Eory L., Zhang W., Schoenebeck J.;
RT   "Long-read based genome assembly of a Labrador retriever dog.";
RL   Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCAFP00845031739.1}
RP   IDENTIFICATION.
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00845031739.1};
RG   Ensembl;
RL   Submitted (JAN-2026) to UniProtKB.
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DR   RefSeq; XP_005634018.1; XM_005633961.4.
DR   RefSeq; XP_038287074.1; XM_038431146.1.
DR   RefSeq; XP_038287075.1; XM_038431147.1.
DR   RefSeq; XP_038425651.1; XM_038569723.1.
DR   RefSeq; XP_038425652.1; XM_038569724.1.
DR   RefSeq; XP_534145.3; XM_534145.7.
DR   AlphaFoldDB; A0A8I3PKF5; -.
DR   SMR; A0A8I3PKF5; -.
DR   FunCoup; A0A8I3PKF5; 248.
DR   Ensembl; ENSCAFT00845040542.1; ENSCAFP00845031739.1; ENSCAFG00845022654.1.
DR   GeneID; 476945; -.
DR   KEGG; cfa:476945; -.
DR   CTD; 10464; -.
DR   GeneTree; ENSGT00390000015293; -.
DR   OMA; KCERDTF; -.
DR   OrthoDB; 299638at2759; -.
DR   Proteomes; UP000805418; Chromosome 22.
DR   GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0005815; C:microtubule organizing center; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0005136; F:interleukin-4 receptor binding; IEA:Ensembl.
DR   GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR   GO; GO:0007080; P:mitotic metaphase chromosome alignment; IEA:Ensembl.
DR   GO; GO:0090307; P:mitotic spindle assembly; IEA:Ensembl.
DR   GO; GO:0032695; P:negative regulation of interleukin-12 production; IEA:Ensembl.
DR   GO; GO:0032815; P:negative regulation of natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0031393; P:negative regulation of prostaglandin biosynthetic process; IEA:Ensembl.
DR   GO; GO:1905515; P:non-motile cilium assembly; IEA:Ensembl.
DR   GO; GO:0032733; P:positive regulation of interleukin-10 production; IEA:Ensembl.
DR   GO; GO:0071539; P:protein localization to centrosome; IEA:Ensembl.
DR   InterPro; IPR026205; PIBF1.
DR   PANTHER; PTHR18950; PROGESTERONE-INDUCED BLOCKING FACTOR 1; 1.
DR   PANTHER; PTHR18950:SF1; PROGESTERONE-INDUCED-BLOCKING FACTOR 1; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000805418}.
FT   COILED          78..155
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          205..239
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          264..448
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          474..550
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          595..667
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   757 AA;  90170 MW;  AF9F8FA6EF4CB416 CRC64;
     MSRKVARASK KVNISSSLES EDISLETTVP TDDISSSEER DGKIKITQQL IERKELLHNI
     QLLKIELSQK NMMIDNLKVD YLTKIEELEE KLNDALHQKQ LLTLRLDNQL TFQQKDAKKY
     QELMKQEMET ILLRQKQLEE TNTQLREKAG DIRRNLRDFE LTEEQYMKLK GFPEDQLSIP
     EYVSIRFYEL VNPLRKEICE LQVKKNDLSE ELSENKAQLK QLTETYEDDR RNYSELQIRC
     QRLVLELADT KQLIQQGDYR QENYDKVKSE RDGLEQEIIE LRRKHEILEA SHIIQAKERS
     ELSKEVTTLQ QTVTLLQKDK DYLNRQNMEL SVRCAHEEDR LERLQVQLEE TKKAREEMYE
     KYVTSRDHYK TEYENKLHDE LEQIRLKTNQ EIDQLRSASR EMYERENRHL REARDNAMAE
     KDRAVMAEKD ALEKHDQLLE RYRELQLSTE SKVMEYLHQS KLKSFETERV QLIQEETARN
     LTQCQLECEK YQKKLEVLTK EFYSLQASSE KRITELQSRN SEHQARLDIY ERLEKELDEI
     IMQTAEIENE DEAERVLFSY GYGANVPTTA KRRLKQSVHL ARRVLQLEKQ NSLVLKDLEH
     QKEQVTQLSQ ELDRANSLLN QTQQPYRYLI ESVRQRDSKI DSLKECITQL EKDVSNLNKE
     KSALLQMKNQ MALDLEQLLN HREELAAMKQ IVTNMRSKRS EDQLLLTKTD AKNMTENHKS
     KTLNVPREHE DNIFIPKPTL FTKKEAPEWS KKQKMKT
//