ID A0A8I3RZD9_CANLF Unreviewed; 516 AA.
AC A0A8I3RZD9;
DT 25-MAY-2022, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 1.
DT 28-JAN-2026, entry version 20.
DE SubName: Full=ADRM1 26S proteasome ubiquitin receptor {ECO:0000313|Ensembl:ENSCAFP00845023115.1};
GN Name=ADRM1 {ECO:0000313|Ensembl:ENSCAFP00845023115.1};
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00845023115.1, ECO:0000313|Proteomes:UP000805418};
RN [1] {ECO:0000313|Ensembl:ENSCAFP00845023115.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Labrador retriever {ECO:0000313|Ensembl:ENSCAFP00845023115.1};
RA Eory L., Zhang W., Schoenebeck J.;
RT "Long-read based genome assembly of a Labrador retriever dog.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCAFP00845023115.1}
RP IDENTIFICATION.
RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00845023115.1};
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSCAFP00845023115.1}
RP IDENTIFICATION.
RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00845023115.1};
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ADRM1 family.
CC {ECO:0000256|ARBA:ARBA00009216}.
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DR AlphaFoldDB; A0A8I3RZD9; -.
DR Ensembl; ENSCAFT00845029415.1; ENSCAFP00845023115.1; ENSCAFG00845016538.1.
DR GeneTree; ENSGT00390000013839; -.
DR OrthoDB; 340431at2759; -.
DR Reactome; R-CFA-1169091; Activation of NF-kappaB in B cells.
DR Reactome; R-CFA-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
DR Reactome; R-CFA-1236978; Cross-presentation of soluble exogenous antigens (endosomes).
DR Reactome; R-CFA-174084; Autodegradation of Cdh1 by Cdh1:APC/C.
DR Reactome; R-CFA-174154; APC/C:Cdc20 mediated degradation of Securin.
DR Reactome; R-CFA-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
DR Reactome; R-CFA-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
DR Reactome; R-CFA-187577; SCF(Skp2)-mediated degradation of p27/p21.
DR Reactome; R-CFA-195253; Degradation of beta-catenin by the destruction complex.
DR Reactome; R-CFA-202424; Downstream TCR signaling.
DR Reactome; R-CFA-2467813; Separation of Sister Chromatids.
DR Reactome; R-CFA-2871837; FCERI mediated NF-kB activation.
DR Reactome; R-CFA-349425; Autodegradation of the E3 ubiquitin ligase COP1.
DR Reactome; R-CFA-350562; Regulation of ornithine decarboxylase (ODC).
DR Reactome; R-CFA-382556; ABC-family proteins mediated transport.
DR Reactome; R-CFA-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA.
DR Reactome; R-CFA-4608870; Asymmetric localization of PCP proteins.
DR Reactome; R-CFA-4641257; Degradation of AXIN.
DR Reactome; R-CFA-4641258; Degradation of DVL.
DR Reactome; R-CFA-5358346; Hedgehog ligand biogenesis.
DR Reactome; R-CFA-5607761; Dectin-1 mediated noncanonical NF-kB signaling.
DR Reactome; R-CFA-5607764; CLEC7A (Dectin-1) signaling.
DR Reactome; R-CFA-5610780; Degradation of GLI1 by the proteasome.
DR Reactome; R-CFA-5610785; GLI3 is processed to GLI3R by the proteasome.
DR Reactome; R-CFA-5632684; Hedgehog 'on' state.
DR Reactome; R-CFA-5658442; Regulation of RAS by GAPs.
DR Reactome; R-CFA-5668541; TNFR2 non-canonical NF-kB pathway.
DR Reactome; R-CFA-5676590; NIK-->noncanonical NF-kB signaling.
DR Reactome; R-CFA-5687128; MAPK6/MAPK4 signaling.
DR Reactome; R-CFA-5689603; UCH proteinases.
DR Reactome; R-CFA-5689880; Ub-specific processing proteases.
DR Reactome; R-CFA-68867; Assembly of the pre-replicative complex.
DR Reactome; R-CFA-68949; Orc1 removal from chromatin.
DR Reactome; R-CFA-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR Reactome; R-CFA-69481; G2/M Checkpoints.
DR Reactome; R-CFA-69601; Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A.
DR Reactome; R-CFA-75815; Ubiquitin-dependent degradation of Cyclin D.
DR Reactome; R-CFA-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint.
DR Reactome; R-CFA-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
DR Reactome; R-CFA-8939902; Regulation of RUNX2 expression and activity.
DR Reactome; R-CFA-8941858; Regulation of RUNX3 expression and activity.
DR Reactome; R-CFA-8948751; Regulation of PTEN stability and activity.
DR Reactome; R-CFA-8951664; Neddylation.
DR Reactome; R-CFA-9020702; Interleukin-1 signaling.
DR Reactome; R-CFA-9755511; KEAP1-NFE2L2 pathway.
DR Reactome; R-CFA-9762114; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2.
DR Reactome; R-CFA-9766229; Degradation of CDH1.
DR Reactome; R-CFA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR Reactome; R-CFA-9907900; Proteasome assembly.
DR Reactome; R-CFA-9932298; Degradation of CRY and PER proteins.
DR Proteomes; UP000805418; Chromosome 24.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IBA:GO_Central.
DR GO; GO:0061133; F:endopeptidase activator activity; IBA:GO_Central.
DR GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR GO; GO:0070628; F:proteasome binding; IBA:GO_Central.
DR GO; GO:0043248; P:proteasome assembly; IEA:Ensembl.
DR GO; GO:0006368; P:transcription elongation by RNA polymerase II; IEA:Ensembl.
DR CDD; cd13314; PH_Rpn13; 1.
DR FunFam; 2.30.29.70:FF:000001; Proteasomal ubiquitin receptor ADRM1; 1.
DR Gene3D; 1.10.2020.20; -; 1.
DR Gene3D; 2.30.29.70; Proteasomal ubiquitin receptor Rpn13/ADRM1; 1.
DR InterPro; IPR044867; DEUBAD_dom.
DR InterPro; IPR006773; Rpn13/ADRM1.
DR InterPro; IPR044868; Rpn13/ADRM1_Pru.
DR InterPro; IPR038633; Rpn13/ADRM1_Pru_sf.
DR InterPro; IPR032368; RPN13_DEUBAD.
DR InterPro; IPR038108; RPN13_DEUBAD_sf.
DR PANTHER; PTHR12225; ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN; 1.
DR PANTHER; PTHR12225:SF0; PROTEASOMAL UBIQUITIN RECEPTOR ADRM1; 1.
DR Pfam; PF04683; Rpn13_ADRM1_Pru; 1.
DR Pfam; PF16550; RPN13_C; 1.
DR PROSITE; PS51916; DEUBAD; 1.
DR PROSITE; PS51917; PRU; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW Reference proteome {ECO:0000313|Proteomes:UP000805418}.
FT DOMAIN 18..131
FT /note="Pru"
FT /evidence="ECO:0000259|PROSITE:PS51917"
FT DOMAIN 277..392
FT /note="DEUBAD"
FT /evidence="ECO:0000259|PROSITE:PS51916"
FT REGION 196..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..248
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 497..507
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 516 AA; 54300 MW; 5153AE286052B7D8 CRC64;
MTTSGALFPS LVPGSRGSSN KYLVEFRAGK MSLKGTTVTP DKRKGLVYIQ QTDDSLIHFC
WKDRTSGNVE DDLIIFPDDC EFKRVPQCPS GRVYVLKFKA GSKRLFFWMQ EPKTDQDEEH
CRKVNEYLNN PPMPGALGTS GSGGHELSAL GGEGGLQSLL GNMSHSQLMQ LIGPAGLGGL
GGLGALTGPG LASLLGSGGP PASSSSSSSR SQSAAVTPSS TTSSTRATPA PSAPAAASVT
SPSPAPSSGN GTSTAASPTQ PIQLSDLQSI LATMNVPAGP GGGQQVDLAS VLTPEIMAPI
LANADVQERL LPYLPSGESL PQTAEEIQNT LTSPQFQQVE AMAWVPCLQR GSLSLSVPPP
ATGPRTSFSP GAQACLAFLC RPWACSAQRW PRGSWAPSCA SLGCLQRPWR RPTRAVSAPP
PPTHTHTKAE FVLILIVQRP PLFAQPGAGH PGVGSRWSWA LIWSAVPGQG LERSPLVFKR
VLDVEAFAKA MQNSARSEQE GDGKDKKDEE EDMSLD
//
