ID A0A8I3S6P3_CANLF Unreviewed; 482 AA.
AC A0A8I3S6P3;
DT 25-MAY-2022, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 1.
DT 28-JAN-2026, entry version 20.
DE SubName: Full=Interferon induced protein with tetratricopeptide repeats 5 {ECO:0000313|Ensembl:ENSCAFP00845039251.1};
GN Name=IFIT5 {ECO:0000313|Ensembl:ENSCAFP00845039251.1};
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00845039251.1, ECO:0000313|Proteomes:UP000805418};
RN [1] {ECO:0000313|Ensembl:ENSCAFP00845039251.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Labrador retriever {ECO:0000313|Ensembl:ENSCAFP00845039251.1};
RA Eory L., Zhang W., Schoenebeck J.;
RT "Long-read based genome assembly of a Labrador retriever dog.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCAFP00845039251.1}
RP IDENTIFICATION.
RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00845039251.1};
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSCAFP00845039251.1}
RP IDENTIFICATION.
RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00845039251.1};
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SIMILARITY: Belongs to the IFIT family.
CC {ECO:0000256|ARBA:ARBA00038336}.
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DR RefSeq; XP_038295813.1; XM_038439885.1.
DR AlphaFoldDB; A0A8I3S6P3; -.
DR Ensembl; ENSCAFT00845050060.1; ENSCAFP00845039251.1; ENSCAFG00845028375.1.
DR GeneID; 486788; -.
DR CTD; 24138; -.
DR GeneTree; ENSGT00950000182946; -.
DR OrthoDB; 10043504at2759; -.
DR Proteomes; UP000805418; Chromosome 28.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR FunFam; 1.25.40.10:FF:000036; interferon-induced protein with tetratricopeptide repeats 5; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR013105; TPR_2.
DR InterPro; IPR019734; TPR_rpt.
DR PANTHER; PTHR10271; INTERFERON-INDUCED PROTEIN WITH TETRATRICOPEPTIDE REPEATS; 1.
DR PANTHER; PTHR10271:SF28; INTERFERON-INDUCED PROTEIN WITH TETRATRICOPEPTIDE REPEATS 5; 1.
DR Pfam; PF13424; TPR_12; 1.
DR Pfam; PF07719; TPR_2; 1.
DR Pfam; PF13176; TPR_7; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 5.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 3.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Reference proteome {ECO:0000313|Proteomes:UP000805418};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 249..282
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 338..371
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 435..468
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT COILED 60..94
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 482 AA; 55943 MW; A63876C6B2FF8AE5 CRC64;
MSEIPKESLK AILLELECHF TWNLLKEDID LFDVEDTIGQ QLEFLTTKSR LTLYNLLAYV
KHLKGQNEDA LKCLEQAEEI IRREHSDKEE IRSLVTWGNY AWVYYHMDQL KESQKYIDKI
GNVCKKLSSP SNYKLERPEI DCEKGWALLK FGGKYYQKAK AAFEKALEVE PDNPEFNIGY
AITVYRLDDS DREGSIKSFS LGPLRKAVTL NPDNSYIKVF LALKLQDVHA EAEGERYIEE
ILDQISSQPY VLRYAAKFYR RKNSWDKALE LLKKALEVTP TSSFLHHQMG LCYRAQMIQI
KKATRNRPKG KDKMKVDELI TSAIFHFRAA VERDSMFAFA YTDLANMYAE GGQYSNAEDV
FQKALRLENI TDDHKHQIHY HYGRFQEFHR KSESTAIHHY LEALKVKDRS SLRTKLASAL
KKLAIKRLGH NASDVQSLSA LGFVYKLEGE KRQAAEYYER AQKIDPENAE FLTALCELRL
SV
//
