ID A0A8J0TU61_XENLA Unreviewed; 663 AA.
AC A0A8J0TU61;
DT 25-MAY-2022, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 1.
DT 28-JAN-2026, entry version 20.
DE RecName: Full=Forkhead box protein K2 {ECO:0000256|ARBA:ARBA00072763};
DE AltName: Full=Interleukin enhancer-binding factor 1 {ECO:0000256|ARBA:ARBA00082763};
GN Name=foxk2.L {ECO:0000313|RefSeq:XP_018090931.1,
GN ECO:0000313|Xenbase:XB-GENE-864986};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018090931.1};
RN [1] {ECO:0000313|RefSeq:XP_018090931.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018090931.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018090931.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-
CC ProRule:PRU00089}.
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DR RefSeq; XP_018090931.1; XM_018235442.2.
DR AlphaFoldDB; A0A8J0TU61; -.
DR GeneID; 399427; -.
DR AGR; Xenbase:XB-GENE-864986; -.
DR CTD; 399427; -.
DR Xenbase; XB-GENE-864986; foxk2.L.
DR OrthoDB; 691130at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10L.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-ARBA.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:UniProtKB-ARBA.
DR CDD; cd20055; FH_FOXK2; 1.
DR CDD; cd22723; FHA_FOXK2; 1.
DR FunFam; 1.10.10.10:FF:000030; Forkhead box protein K2; 1.
DR FunFam; 2.60.200.20:FF:000025; Forkhead box protein K2; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047397; FH_FOXK2.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR047398; FHA_FOXK2.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45881; CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR45881:SF3; FORKHEAD BOX PROTEIN K2; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SMART; SM00240; FHA; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..663
FT /note="Forkhead box protein K2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035251611"
FT DOMAIN 70..131
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 259..354
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 259..354
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 241..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 610..636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..259
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..393
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 627..636
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 663 AA; 70897 MW; EEFAC7480F4DB505 CRC64;
MFGCAWTAPI FPFSLAGFAG SEPPPELPSP PVPSLPPARK MAVAVCGAVV PVVARLEGRE
FEYLMKKRSV TIGRNSSQGC VDVSMGHSSF ISRRHLEIFI GGSGDGDDAD VGDFYLRCLG
KNGVFVDGVF QRRGAPPLQL PRVCTFRFPS TNIKITFTAL AIDKKQKLEA PESPVKPVQP
QISPLTIHIP DNIAHLISPL PSPTGTISAA NSCPSSPRGA GSSGFKFGRV IPPDLIAEAA
QSENDKDASG GDSPKDDSKP PYSYAQLIVQ AITMAPDKQL TLNGIYTHIT KNYPYYRTAD
KGWQNSIRHN LSLNRYFIKV PRSQEEPGKG SFWRIDPASE SKLVEQAFRK RRPRGVPCFR
TPLGPLSSRS APASPNHSGV FSAHSSGVQT PESLSREGSP IPLEPDASVI HPKLAVIQEA
RFAQSAPGSP LSSQPVLITV QRQLPQTIKP VTYTVAAPVT TATSQQAVMQ TVHVVHQIPA
VSVTNVTGLT PINTYTVGGQ TMVAQAAVMA QPKLEHQENG DHKEVKVKVE AIPAIGHPAL
TTASRIIQTS SSAPLQTVTI VQTPLGQHQL PIKAVTQNGT HVVPITTAIQ GQVTTAAASP
LHMLATHASA SASLPTKRQN GDQSEQPDIK RGKTDEREVL AMTGLDAQSE MAMAASNEQE
NQK
//
