ID A0A8J0UJ13_XENLA Unreviewed; 667 AA.
AC A0A8J0UJ13;
DT 25-MAY-2022, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 1.
DT 28-JAN-2026, entry version 16.
DE SubName: Full=Forkhead box protein N1 isoform X1 {ECO:0000313|RefSeq:XP_018104265.1, ECO:0000313|RefSeq:XP_018104266.1};
GN Name=foxn1.S {ECO:0000313|RefSeq:XP_018104265.1,
GN ECO:0000313|RefSeq:XP_018104266.1, ECO:0000313|RefSeq:XP_041439248.1,
GN ECO:0000313|RefSeq:XP_041439249.1,
GN ECO:0000313|Xenbase:XB-GENE-17342700};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|RefSeq:XP_018104265.1};
RN [1] {ECO:0000313|RefSeq:XP_018104265.1, ECO:0000313|RefSeq:XP_018104266.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|Proteomes:UP000186698,
RC ECO:0000313|RefSeq:XP_018104265.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018104265.1,
RC ECO:0000313|RefSeq:XP_018104266.1};
RG RefSeq;
RL Submitted (APR-2022) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR RefSeq; XP_018104265.1; XM_018248776.2.
DR RefSeq; XP_018104266.1; XM_018248777.2.
DR RefSeq; XP_041439248.1; XM_041583314.1.
DR RefSeq; XP_041439249.1; XM_041583315.1.
DR AlphaFoldDB; A0A8J0UJ13; -.
DR GeneID; 108709167; -.
DR KEGG; xla:108709167; -.
DR AGR; Xenbase:XB-GENE-17342700; -.
DR CTD; 108709167; -.
DR Xenbase; XB-GENE-17342700; foxn1.S.
DR OrthoDB; 10070006at2759; -.
DR Proteomes; UP000186698; Chromosome 2S.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd20056; FH_FOXN1; 1.
DR FunFam; 1.10.10.10:FF:000122; Forkhead box protein N1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047401; FH_FOXN1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR049624; FOXN1_4.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46721; FORKHEAD BOX PROTEIN N1; 1.
DR PANTHER; PTHR46721:SF1; FORKHEAD BOX PROTEIN N1; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 299..395
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 299..395
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 90..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..524
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 667 AA; 75078 MW; 08742A4607938B82 CRC64;
MESEKEEFSP LDNEMVNSQS GFVHNQELFT SSIMQDQSNL TFSSGSLDNE CSPINQPEDA
MLEKPGPASS CLHMDTYGSH TIDINIQGER KNSDSSMSPT LSPPQEHIQM GFPSKSSPRE
LFRRYSCDDT TERSYSNFIK DRNQFNPYKR QFSDVFPNTL DSLSLSEKTF KEINRIDTFE
DMCAPPGPEY IEPFAPHMPD ISTEQAWCNS VQYNSTPDED SQLMLGSVVK IKSSAMGQQE
KEQRMYWTQT QQLYCSPQSF PQYSTGGSFP VSYISTAQYP YQRIAPQASM ETQQPLYPKP
IYSYSILIFM ALKNSKTGSL PVSEIYNFMT ENFPYFKTAP DGWKNSVRHN LSLNKCFEKV
ENKSGSSSRK GCLWALNPAK IEKMQEELQK WKRKDPVTVR KSMAKPEDLD KLIGERTEKL
RSSLLAHNGA GLVNSTTMQL SMQTSLCETT ISPMPVPLQS VRDISASLQD NSHLVRQQPP
CYTPLPHDIP LISPAMIQQP RGISHNHFSS PDNQSDLRAQ PINPQDSPIP AHTPPHQTMN
LLTQHSPTRT MQENLAEVEL SNDIDDLNPS LTDFDFQGSL WEELRDDSLV LDPLNLVSPS
PTPPPPQYFV HNSASKGFSN GTGSPNNNLN MSYGDIHLTT VYSSFVELDK QMPSYLSTCG
SKHLAIV
//
