ID A0A8J1INK2_XENTR Unreviewed; 467 AA.
AC A0A8J1INK2;
DT 25-MAY-2022, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 1.
DT 28-JAN-2026, entry version 19.
DE SubName: Full=Suppressor of cytokine signaling 4 isoform X1 {ECO:0000313|RefSeq:XP_031746340.1};
GN Name=socs4 {ECO:0000313|RefSeq:XP_031746340.1,
GN ECO:0000313|Xenbase:XB-GENE-481718};
GN Synonyms=socs7 {ECO:0000313|RefSeq:XP_031746340.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Proteomes:UP000008143, ECO:0000313|RefSeq:XP_031746340.1};
RN [1] {ECO:0000313|RefSeq:XP_031746340.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_031746340.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_031746340.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_031746340.1; XM_031890480.1.
DR AlphaFoldDB; A0A8J1INK2; -.
DR GeneID; 549828; -.
DR AGR; Xenbase:XB-GENE-481718; -.
DR CTD; 122809; -.
DR Xenbase; XB-GENE-481718; socs4.
DR OMA; RINNNPC; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000008143; Chromosome 8.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd10385; SH2_SOCS4; 1.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR035864; SOCS4_SH2.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF21; SUPPRESSOR OF CYTOKINE SIGNALING 4; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 309..404
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 399..448
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 238..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 467 AA; 53076 MW; 314E556E1CC8D184 CRC64;
MAPSHACHAL TETRAEEQIT HTSDEKNSWV IMAENIEDKL GELDVRPKSS RSRSADRKDG
YVWSGKKLTW LNKNGHSSDG DTINVVEDED CATQSQERKH SCSSIELDLD RSCGHKILGR
SLKQKLQDAV GQCFPIKTCS NRHSSTLSSK RKIHISELML DKCPFPPKSD LAYRWHLIKR
HTAPVSQTKG EWVINDGLDL DGKEIQVKDK NSDGGEDCLL DGHATPCKVN IGNVESLGTK
GSRSSKEDSD LDSDDEAVTL CSSSRKRNKP KWETDDESFQ AETPPKYHTQ IDYVHCLVPD
LFQINNNPCY WGVMDRYAAE ALLEGKPEGT FLLRDSAQED YLFSVSFRRY SRSLHARIEQ
WNHNFSFDAH DPCVFHAPNV TGLLEHYKDP SSCMFFEPLL SSPLNRTFPF TLQHICRAAI
CTSTNYDGID ALPVPSSMKL YLKEYHYKSK VRVRRVDAPE QRNMKQF
//
