ID A0A8J1M967_XENLA Unreviewed; 2505 AA.
AC A0A8J1M967;
DT 25-MAY-2022, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 1.
DT 10-JUN-2026, entry version 19.
DE SubName: Full=Nuclear receptor corepressor 1-like isoform X13 {ECO:0000313|RefSeq:XP_041437595.1};
GN Name=ncor1.L {ECO:0000313|RefSeq:XP_041437595.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_041437595.1};
RN [1] {ECO:0000313|RefSeq:XP_041437595.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_041437595.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_041437595.1};
RG RefSeq;
RL Submitted (JAN-2026) to UniProtKB.
CC -!- SIMILARITY: Belongs to the N-CoR nuclear receptor corepressors family.
CC {ECO:0000256|ARBA:ARBA00010097}.
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DR RefSeq; XP_041437595.1; XM_041581661.1.
DR GeneID; 108707936; -.
DR CTD; 108707936; -.
DR Proteomes; UP000186698; Chromosome 2L.
DR GO; GO:0000785; C:chromatin; IEA:TreeGrafter.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-ARBA.
DR GO; GO:0032991; C:protein-containing complex; IEA:UniProtKB-ARBA.
DR GO; GO:0046966; F:nuclear thyroid hormone receptor binding; IEA:TreeGrafter.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:TreeGrafter.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:TreeGrafter.
DR CDD; cd00167; SANT; 1.
DR FunFam; 1.20.58.1880:FF:000010; Nuclear receptor corepressor 1; 1.
DR FunFam; 1.20.5.430:FF:000001; Nuclear receptor corepressor 2 isoform 1; 1.
DR Gene3D; 1.20.5.430; -; 1.
DR Gene3D; 1.20.58.1880; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeodomain-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR051571; N-CoR_corepressor.
DR InterPro; IPR031557; N-CoR_GPS2_interact.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR PANTHER; PTHR13992; NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR; 1.
DR PANTHER; PTHR13992:SF5; NUCLEAR RECEPTOR COREPRESSOR 1; 1.
DR Pfam; PF15784; GPS2_interact; 1.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR Pfam; PF27579; NCOR1_N; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS51294; HTH_MYB; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
DR PROSITE; PS51293; SANT; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698}.
FT DOMAIN 432..466
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 604..654
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT DOMAIN 607..658
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 611..658
FT /note="HTH myb-type"
FT /evidence="ECO:0000259|PROSITE:PS51294"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 54..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 133..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 198..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 469..620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..849
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 865..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1075..1100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1484..1549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1750..1845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1917..1997
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2026..2114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2140..2226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2346..2425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2457..2505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..82
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..106
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..148
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..496
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..519
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..583
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 584..599
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 611..620
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 682..692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..712
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..731
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 756..768
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 819..849
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 871..882
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1484..1493
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1497..1508
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1537..1549
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1773..1811
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1923..1944
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1961..1979
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1986..1997
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2035..2044
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2047..2056
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2101..2112
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2140..2191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2192..2211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2355..2364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2387..2401
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2457..2483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2496..2505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2505 AA; 278379 MW; BCE8E7CA74E76CCC CRC64;
MSSSGYPPNQ GAFSTEQGRY SSHPVQYTFP SSRHQQEYSV SEYRTAHLEA SQLIQQQQLR
RRPSLLSEFH PVSDRPQDRR SGYDQQYHSI SQNEHEALES KRPRLDQVSD SHYRLNPAMV
PLVPTIQEGV RVQSEVKKEQ GLSSKHESSS SPLSGQPGDD QDASPSKLSK EELIQSMDRV
DREIAKVEQQ ILKLKKKQQQ LEEEAAKPPE PEKPVSPPPV EQKHRSVVQI IYDENRKKAE
EAHKFLEGLG PKVELSFLLQ PLYNQPSDTK VYHENIKTNQ VMRKKLILFF KRRNHARKLR
EQNICQRYDQ LMEAWEKKVD RIENNPRRKA KESKTREYYE KQFPEIRKQR EQQERFQRVG
QRGTGMSATI ARSEHEISEI IDGLSEQENN EKQMRQLSVI PPMMFDAEQR RVKFINMNGL
MEDPMKVYKD RQFMNVWTDH EKEIFKEKFV QHPKNFGLIA SYLERKQQIT RPSQEEKEIE
KVEEEKADRN DKKEDERREE EEKEEKEELR EGAKDKIDAV AEDGDEKDQS MPRGRKTANS
QGRRKGRITR SMASEAAAAN AVTTATTAPV TTTSTTATTV APVPVAPPPE EPTPPPPPQE
QTSADTVETS RWTEEEMEVA KKGLVDHGRN WGAIAKMVGS KSESQCKNFY FNYKRRHNLD
NLLQQHKQKS SRRPREERDV SQCESIASTV SAQEDEENEG SNEEENPEDS EGAENSSDTE
SAPSPSPAEA AKLGDDAVDR TTSSVYIEAP PEQDAASKPA SSSTPSPSVE NTKPPETPYA
ELKVKEEIST ETEETMEVEE RSQSAEMKSA LSLQVQTKAE PDEAEAKPTE SADVKIEDDS
KDHDMERLMD RAEAADMGYV PPQHISHARQ ESQSDNDSSA TCSADEEVDG EPDRPRIYPL
DSKPSLLNQA GTILISSSMK QVPMDLQQLQ HRAAVIPPMA SCNPLTMGTA VSASNFSMYQ
RHLYENNLLE EQRQRQEQFA LESRMSASPG NLSKSPNVDW EGKSVYMPYT EVKRAFEHEA
QMQHVARSVS PYRLSPREVS RASPQVDMNP ARYCVPPVLQ PAPHQVITSL SDGARLPVTR
PTRPPPPLIP SSKTSAISSD KPSFITGGSI SQGTPGTYLS SLGQPYSQET VKASVGSISL
GLPRQQESTK PGSVTYIKQE EFSPRGQSSQ PEGLLVRAQH EGVVRGTMTA IQEGSITRGT
PATKVENVST LRGSITQGTP ALSQSGIAAD VLLKTTITRL ATEDISSPEK CRDETSAKGH
VIYEGKSGHI VSYDPIKNMR EGTRSPRTAP EVTLKRAYDT MEGNIKQAMS VREAAVSGPM
EGLICRTLPK GSPHPELKDR QVFSGSIMKG TPRTTSDNFD DGHKYTKQIK LESPPIRSYE
GAISKGKPYE GVTTIRELGR SIHEIPRQDL LSQESRKTPE SSRQIMEGSI SQGTPIKYES
TSGQSAIKHN VKSLITGPSN LSRGVPQMDV MPENLKIGER LKHEDTKSSE AIRSRHTSVV
SSGPSVLRST LHEASKSQLS PGIYEDNNAR RTPVNYPSPM SRNSPMPRSS EGRCIFPENI
IFGGLTPGKS SSHERKSTLT PTLRESIVVK SPVPGVDPSA AHSPFDPHLR SAPPGDVYRA
HLPPHLDPSL QFHRPLDPAA AAAYLFQRQL SPTPGYPSQY QLYAMENTRQ TILNDYITSQ
QMQVNLRPDV ARGLSPRDQG LAIPYPGARG IIDLTNMPPA ILVPHPGGTS TPPMDRITYI
PGTQLAFPPR SYNPASMSPG HPTHLAAANS ASAERERERE RERERDRERD REREKEQRER
ERDRERERER LAVAAAASAP SEHYLRPVSE QPGRPSSHGY VRSPSPSVRA QESIMQQRPS
IFQGTNGKSV ITPLDAAQLR IMPPTPGAAS ITQGIPASRY STAADALAAL VDAAASAPQM
EVSKPKESKH DSARTEESLS RRNALEQQQQ QQIDCERRVV QSPYTSSSFS SSKSQSQASP
AVYSEAGKER AAHTKSRYVE ELRMRGKTTI TAANFIDVII TQQIASDKDG RDRNSQSSDS
SSSHSSHRYE APRETIEVIS PASSPVQEKE SYPQEIPKSS QTETGEGSRK YEGQPNRYRQ
PQESPSPQQS IPGHVPQTHR LITLADHICH IITQDFARNQ PVNQQPPAST FQSTNPSSTP
VRTKASSRFS PESQVQPVHN QRPASRVSPE NISDKPRGRP GKSPDRGHIS EPYEPISPPQ
APHVHAKQDS MMLLPQRQEP PEQRNDSRSP GNINYLPSFF TKLENTSPMV MYKKQEIFRK
LNSSGGGDSD MAAAQPGTEI FNLPAVTTSG AISSRGHSFA DPASNLGLED IIRKALMGNF
DDKSEDHGVL VGVPQGNQSG TPNSEARREE ANPSPNSVLH VTGGGTHKQK LISKYGSRKT
KSPVSGSQTY LGAERPSSVS SVHSEGDYRQ TSAWAWEDRP SSTGSTQFPY NPLTMGMLNS
TPPSSMSCAP TSMTQTPAHQ QSRIWEREPA PLLSEQYETL SDSDE
//
