ID A0A8J1TSW4_OWEFU Unreviewed; 1380 AA.
AC A0A8J1TSW4;
DT 25-MAY-2022, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 1.
DT 18-JUN-2025, entry version 16.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN ORFNames=OFUS_LOCUS14666 {ECO:0000313|EMBL:CAH1789278.1};
OS Owenia fusiformis (Polychaete worm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Sedentaria; Canalipalpata; Sabellida; Oweniida; Oweniidae; Owenia.
OX NCBI_TaxID=6347 {ECO:0000313|EMBL:CAH1789278.1, ECO:0000313|Proteomes:UP000749559};
RN [1] {ECO:0000313|EMBL:CAH1789278.1}
RP NUCLEOTIDE SEQUENCE.
RA Martin C.;
RL Submitted (MAR-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
CC -!- SIMILARITY: Belongs to the RBR family. Ariadne subfamily.
CC {ECO:0000256|ARBA:ARBA00005884}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CAH1789278.1}.
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DR EMBL; CAIIXF020000007; CAH1789278.1; -; Genomic_DNA.
DR OrthoDB; 69641at2759; -.
DR Proteomes; UP000749559; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd20346; BRcat_RBR_ANKIB1; 1.
DR CDD; cd20361; Rcat_RBR_ANKIB1; 1.
DR FunFam; 1.20.120.1750:FF:000003; RBR-type E3 ubiquitin transferase; 1.
DR FunFam; 1.25.40.20:FF:000040; RBR-type E3 ubiquitin transferase; 1.
DR FunFam; 3.30.40.10:FF:000019; RBR-type E3 ubiquitin transferase; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR045840; Ariadne.
DR InterPro; IPR031127; E3_UB_ligase_RBR.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR047564; Rcat_RBR_ANKIB1.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR003903; UIM_dom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF19422; Ariadne; 1.
DR Pfam; PF01485; IBR; 1.
DR Pfam; PF22191; IBR_1; 1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00647; IBR; 2.
DR SMART; SM00726; UIM; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS50330; UIM; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000749559};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT REGION 773..810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 883..925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1007..1072
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1144..1176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1194..1267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1315..1380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 899..911
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1007..1022
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1023..1035
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1194..1211
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1224..1239
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1338..1355
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1364..1373
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1380 AA; 153864 MW; DF76DC33D9D39710 CRC64;
MGSASTKFRK HLQTGDEYAA LHLYNNSSDL RKGLDPNISY GDHYNHETPL HYAAKHGMKS
LLRIFLNELQ GNPNKKNSRN ETSLHCVCMA MNGQNFSVQQ RRLECLMLIL QWKGATLKDG
EVEKADLGGQ DEKQNTALHY AAASGLKKSV ELLVSQGAPL FTENEQKQTP CDCAEKNNHS
NIALYLESKM VFSNESEDEQ QEETDDMNQL IDTMEDYCGL RAQDLQEAKD QLLVETSDML
RVPLFTAEAL LRNHEWSREM LLEAWMGDPI ACCEKCGVTP PPNLFEDRPM AGPPQSVDHD
LTTPTYASAP ADAVCDICAG LIGHSEEELV PMQCDHAFCR GCWNRYLTGK IQEGDTHNIG
CPAYQCHKLV PVEVIETIVS RDMARRYLQF DIKAFVDSNP NIKWCPYPGC GRAVKLPEAE
ASTPTTPKPR DLTETSHAVD CGNGHYFCWE CLGEAHEPVN CDSWKDWFTK ISEIKPEELD
GTADTSESAA NCLWLVTNSK PCPQCKSPIQ KNEGCNHMKC SKCKSDFCWV CLEPWKKHSS
ATGGYFRCNR YEVVKKVEEN TENLKSDAER NNKKAQEMNR FVHYYTRFKN HENSYKLEEP
LITTAKEKMM VLAKAITDPD TANIETKFVE EGVVQLLKAR RVLKCSYAYG YFLEDTGYKK
PIFEFMQTEL EECTESLSEM IARPYLRTPR AKIIQTAHTV QRKRHEFVQA IAKGLVPADN
SPYRKRKTRF SIDLDDDLKK ALIESLKDLD PHNPWIKDPT GRHTNVAALL DWPEESDDSD
TEVSPVPIAT STSNLSSSPP PPTNNNSGIC ARGGCMRQKA QNPRTGTLHD HCSLRCMRLD
RIEKQELKKE GGVQPTREFV TDYQIDLLRA LEMSRLQFIR DDQTVAASGR RPDTPPGNSP
VSSTQDIPSS SQKDDVTSPD ISDVVKSKHE GGVVKRAVLE NLEDFDREFN RALEMSREED
NDLTMAIRLS LQDSGEDDLV AGRQRRVPSR EELPMISSVV AKVPNKSVED IHEASSHGDS
RVRSTSVGSR SRSGTMGSEF ELLGATGGAA PRPPISPKVR FSDDETTEDQ GDCLFPQADI
SKTIEHTLNS VNSSPFGLIK DINVSNIFVK DTDKTKNFEQ KYFLYNNKKE DGIFEPRLLD
SSNASNAHEN DLGLPSVGNP RRGRSREEPS INPQFSSIVM KCPNSVSVLD TVSRSPSELG
SSFSLDSTVS KSSKRETGRT GSFSSLQGSS RSGRSSLQSD ATARCQSDPL RHDNTALGPD
HTGLGPAAPI DVWIKQTTEQ VNQQAQQTQQ QRVDDTLDTA LHNLTTLSNE LNYTQSRVRD
TSSSQSSSQP DTVELAHMTS SGSEVTGDTR SWSSESNEHG QEQSNNSSGN STSKGDAVFV
//
