ID A0A8J2HNU4_COTCN Unreviewed; 1707 AA.
AC A0A8J2HNU4;
DT 25-MAY-2022, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 1.
DT 02-APR-2025, entry version 12.
DE SubName: Full=Similar to LUBEL: E3 ubiquitin-protein ligase lubel (Drosophila melanogaster) {ECO:0000313|EMBL:CAG5106856.1};
GN ORFNames=HICCMSTLAB_LOCUS12469 {ECO:0000313|EMBL:CAG5106856.1};
OS Cotesia congregata (Parasitoid wasp) (Apanteles congregatus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Ichneumonoidea; Braconidae;
OC Microgastrinae; Cotesia.
OX NCBI_TaxID=51543 {ECO:0000313|EMBL:CAG5106856.1, ECO:0000313|Proteomes:UP000786811};
RN [1] {ECO:0000313|EMBL:CAG5106856.1}
RP NUCLEOTIDE SEQUENCE.
RA Chebbi M.A.C M.;
RL Submitted (APR-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CAG5106856.1}.
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DR EMBL; CAJNRD030001124; CAG5106856.1; -; Genomic_DNA.
DR OrthoDB; 9978677at2759; -.
DR Proteomes; UP000786811; Unassembled WGS sequence.
DR GO; GO:0071797; C:LUBAC complex; IEA:InterPro.
DR GO; GO:0036435; F:K48-linked polyubiquitin modification-dependent protein binding; IEA:TreeGrafter.
DR GO; GO:0070530; F:K63-linked polyubiquitin modification-dependent protein binding; IEA:TreeGrafter.
DR GO; GO:1990450; F:linear polyubiquitin binding; IEA:TreeGrafter.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:TreeGrafter.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0097039; P:protein linear polyubiquitination; IEA:TreeGrafter.
DR CDD; cd20337; BRcat_RBR_HOIP; 1.
DR CDD; cd20351; Rcat_RBR_HOIP; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR047540; BRcat_RBR_RNF31-like.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR047542; Rcat_RBR_RNF31-like.
DR InterPro; IPR026254; RNF31-like.
DR InterPro; IPR041031; RNF31_C.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR16004:SF2; E3 UBIQUITIN-PROTEIN LIGASE LUBEL; 1.
DR PANTHER; PTHR16004; RING FINGER PROTEIN 31-RELATED; 1.
DR Pfam; PF18091; E3_UbLigase_RBR; 2.
DR Pfam; PF01485; IBR; 1.
DR Pfam; PF22191; IBR_1; 1.
DR SMART; SM00647; IBR; 1.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000786811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 1286..1522
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 1290..1339
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 77..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 126..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 887..923
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 983..1060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1090..1125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1206..1234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..152
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 896..916
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 997..1049
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1105..1121
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1707 AA; 192095 MW; 7E96732AAA205977 CRC64;
MRIWGPPAGV ENDEAAPRKD AANEAGVAGL SELVGGAMDL DALKQVIPSL DNLAELQAGC
KQDSTRTKPT DQLLKNVQEA DDKNIGNNSN DLSNSFKDSD KPCTSPSSKT DLNKLESGKI
LLQENGDIGN KIESAEQKSD EKDIEQTEEI KNQSDSSAKN LAVENLLLAT KLSEQVPIEE
FSAKLEPKVV SNDKIDEILN VPIETPQVST QASEIVDKEV VKEENKLEVN LPVKISSEEV
VKIEQEVIEE KPIKEDVKLS IDASSESKKL LETEETVVET NSPVKEEIIV GSVSEVDKSD
ILNITKNKDE EVFDKAVRIS ESEIKFESQE KLNQATPTVL SAPPSRMTAL KSLKNRLTSM
ISKFPSMKLS YEKPESMGIN QVNYKESMDS SLYSHPNLII NNINQHASNG INNHNNTDKL
NDDIISLDCA STQNHLKTFI SSATITPTNK EVVQKINGIN KYNETINSAS SSDDQAVLKN
NTKEYESSVF FQNTLSNPES RDIKRSTMYI EPLMVSKDKK NEDYVKNNVE VVATVDVEVN
EENHKLKDQD LKIKMTETEN NYKNLQIYQE VDNVMEYNNF EKIDSNENNM EVDIVNESGD
KDDLFVDASS SPETFELKIT EAPLLIVNDA APVENPAVVR GSLTINLSQF SDMKELTTEM
LQFASQEILE NESTGPLSPL EAELPEIFSA SSKIETSIEI NESAVKTDSV QTNYFIPKPK
GRSKSPVKRS FVLRKLPARK CFVGTKRSFN FGGVPKDTAL TRAKECADKI AAKSLMSSRS
VNQVKKAEVV DVNRKGECDK KQELVSQTEK VEREKKMNLS SQKIDKNFIN KPTPKSKLPS
RIPIFQKKPW VAGQTISVAS QKIIEVNVLK PTNSSFNVPR RTIPVLQPLV GPPADNKNQN
GGNQSNEVSK NVNGKVQSEK ENKNCISKLR DDGKLLTNNE TAQSKNSSKN IIRGLTFIKD
ENDTSGIDKS KINESVNPEI DFKDEFNKYS SEASVDVSDD EEEVDDDDEE EEEFEEIEEI
EIEDEESSEE ISDEEEIEEK EEELSDSETT DTNTKSSVIM RRINSTEELT NAELMLKKTL
DNIKAEISDS EYEEISSNSQ KSEGSDEAEL SEANDLPEDP IELSTTKNDV DVESTIVLTL
PKRKSTEIEG EENAVTQSTS KTIRLKDSKV LKVRVTEPEV VVHKKKESRK RFSIVAEYVQ
QFEGDSLNHE RRNSKTKQQE SLKITRDQSP VNERERTARR LLAEGRVSSY DEAEIAASLI
GLKFQDDEAI HAAQECTSVE SAIAFLQQEC ELCTGRFAVS QMISMLKCIH RCCNDCAKNY
FTIQISDRNI MDAVCPFCKE PDLKDATEDE VLEYFSILDI QLKSLLDPPI HELFQRKLRD
RTLMQDPNFK WCAQCSSGFY ANPNQKRLIC PDCRSVTCAF CRKPWEKQHE GITCEQFEEW
KNENDPDNQA IGLAKHLADN GIDCPKCKFR YSLSRGGCMH FTCNQCKYEF CCGCGKAFMM
GAKCTVSPYC AKLGLHSHHP RNCLFYLRDK EPAQLQSLLK GHGIEFNTEN SSGDRKCKVQ
LQKETPTGVI DAVCNSDVVE NHAGLCRIHY IEYLVRKIRL SKLEPLSLFS IDDLETCIKR
AGLNLPANWY RRDPEDYRRD LAEHYVEYLA GLVLKSKLDP VTIFDLNETK QELRRRGKVP
PIKAQEMSEQ DYLRTCIQVV QKEIPLE
//
