ID A0A8J4FI56_9CHLO Unreviewed; 4624 AA.
AC A0A8J4FI56;
DT 25-MAY-2022, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 1.
DT 02-APR-2025, entry version 14.
DE RecName: Full=Non-specific serine/threonine protein kinase {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=Vretifemale_5200 {ECO:0000313|EMBL:GIL75399.1};
OS Volvox reticuliferus.
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Volvocaceae; Volvox.
OX NCBI_TaxID=1737510 {ECO:0000313|EMBL:GIL75399.1, ECO:0000313|Proteomes:UP000747110};
RN [1] {ECO:0000313|EMBL:GIL75399.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NIES-3786 {ECO:0000313|EMBL:GIL75399.1};
RA Yamamoto K., Hamaji T., Kawai-Toyooka H., Matsuzaki R., Takahashi F.,
RA Nishimura Y., Kawachi M., Noguchi H., Minakuchi Y., Umen J.G., Toyoda A.,
RA Nozaki H.;
RT "Three genomes in the algal genus Volvox reveal the fate of a haploid sex-
RT determining region after a transition to homothallism.";
RL Proc. Natl. Acad. Sci. U.S.A. 0:0-0(2021).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GIL75399.1}.
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DR EMBL; BNCP01000007; GIL75399.1; -; Genomic_DNA.
DR OrthoDB; 515939at2759; -.
DR Proteomes; UP000747110; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:TreeGrafter.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR FunFam; 1.10.1070.11:FF:000096; Phosphatidylinositol 3-kinase-related protein kinase; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 3.30.1010.10; Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4; 1.
DR InterPro; IPR050517; DDR_Repair_Kinase.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR031559; SMG1.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF124; NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF15785; SMG1; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161};
KW Reference proteome {ECO:0000313|Proteomes:UP000747110}.
FT DOMAIN 2557..2919
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 4592..4624
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 195..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 247..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 816..845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1292..1398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1481..1506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1959..2034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2130..2160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3275..3294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3795..3887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3915..3969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4436..4477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2894..2963
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 209..221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..272
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 816..828
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1314..1337
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1358..1387
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1968..1978
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2142..2151
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3915..3925
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3932..3944
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4460..4475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:GIL75399.1"
SQ SEQUENCE 4624 AA; 478111 MW; 6EBC1E1CF93C78FE CRC64;
PTSTLPAAQR MTADAKESAL ATLHLCVAAM SPPEVGPFAQ PLLRLTMALL EATTTPPCLL
GPLLRLLLAV LPAVPLAALG QGFGDLVDLL CGWALEPLVA TEDRQLITLI LHALRPQWHS
HPDLTASLTE NMFDDVKAAS ASMAAAVSAA AAAATTSAEG NTDAINQAAA CMQLVQLLCD
IFSAASLRNP PLTGVANLEE PARGPPNSIG PQDTVHPQQP TQPAMLQEPL VRAPAGGLQA
SQVNKLHPQP NHQEQAQLPV KQQQLPQQKQ QQLHGPAAMH ISSNAKGPAV NVFPRRPRAP
PAPPLALTAI LPTRPGAATV RHLICLYPRL LAALREVRGS LVSLNAICGG ILRLKPSDAE
SWAIRLCTCV EILADSVGSC VTGIDPRDVD EVWEGLGNGV LGRLAALTLH GQDQGPARTG
ASQIEAAIVV SYQLSSSPDN AVGTYGAVGA VVAIAAPKAL GCYDVPEADP AGGLGQELAG
DDVSGSASEA ILTTPPNLGQ ISRTRDRGSS LRLWALRKAL EWALSLLSGS ADGGQGVSGA
CWDTRPSGPG PDAEALSGFA VKLVVIAVDQ DADAGRRLLV ELVLEGQGGS MGICGLRSSP
CISSVAAAAK LLQALLSHEH QGVMIASLDW LLEDLRLRLA ALQPGIAPSL PSQPFSCPVS
NAAAVEGDYS GDASAAVAAS FDCAVLQAAC QRNLLAGKSL LRVEAAMWRA LRTAMSPAVL
QAVLDQNPLP RQSTTAPDSV QPSGDALGNG KREVLLAQGE SRPGERAGIL SAQAQAVSQK
WQPLPLSMAT SLCGAWSSSA VALIAAVCRP GWAGASAADS ASPDSRSGLS GISKAPDKDP
QSSIDTRAAS AAARTCCGAY LHAIHALQTG FGRTTDVGSS LQLHAVLALQ RLVKHSAIVA
SGALRCEQLF HLAWQTVSAG ATSWDARVRT ASVDCAVDMV SNVLHPMLLP VAPGDGQVVS
ANVEERVPLP PLPPPPRAEV FAPLVALAFD ALADPSVDSA ASAVRLSTAL LEAALLTTLR
GQGVCGAWVP VWQDSLAVAP SRRVPRVQQV ARLLELVFQS SAAQGNVLLR KRIPAPAAGG
PGANDDGDAG GRMEALQRLA LSMLPAETPE LKTPGGERSS AEVAMAPEGR SGAALVWMAL
QEGAKHMVVA RLRTHLGGPT QTLGALERML QVTYSRLSQE RRDAGPMEVG AAGRESAWLV
LELVGALERA VAHAAEGHAG RDPLPQPVLA FFAANKKVCE EWFTRGRELF TRIASTASAH
HHVVHHGLLR LCDMCGTMRQ MLASLAKERG KAGTSLGLPQ TDAKGGVTGS VDGSQATAAG
ALPSAPSANL PPQSPAQRTG GKHLQRRGGA GGETVPNQQP QAQQQRQQQQ SSAIAPGAAG
SGAAASAGAG GTVGGEEATT APSAVQQLEA NLRRLAFAVV EVLKLVGAAL LAMGEADSLQ
GLHSWAVREF EPLLQGAHLP GASAVAAATA STVADALASC EPGLGGPGQS TPRRRVESAR
GARGSSKPQK DAFAWLLGLS LQASGSYEQA LVSYNAFLAP AHATATPTAA GSCGTPPAQT
PSSIASLELA AATQSFVVER VAECYAALTD WSGLQSLVGA FSHTATVEPV VAGWWPSAAA
SIEHRFRALA AFDTAGPQPA SVDAVPGDQN ANVLLTGLRA LEGAMVAPQP RVAAPAGSTV
PISVNPPGLR PSPQDLVAIR EATSLELSRL LERLRASAYS EPTGQKELLL QASCLSSVIR
ALNLGPKSHT LGSSGPWDGL LLPQVLRAAP VAGGTVKAAS AGSTSGMGFG LGRALLTPDG
GVKAAIVRDV SVAAELLRTV RAGDPHFNLP GTQALSVEHI RAAASTGNWS LGIRLVQGAT
ARVLESEGGT AAGCRAVLSV VHSLLSASSG RLLPGQVVEL QLRALLPHLS SLAAPADDNA
APKTESRRAS DLDSDDLACA LCTLARWMVK AGAAALHQNT PATPLHGPQH HHHPHAHQRL
SSAEPIASSR HAATQPPTGS PPGFSQGHLQ HGQHHRLQGL QHAPPGFTAA STVGRGTAGS
AGALQWLDAA DWPTLSSHFQ RQLVMQHTAE AHHDTFPSAH LAFLVPEALL QSCYAPAACC
LRALQLSPCL ARAWKAWGDL LFRATKEHRA RMVRSQPPRQ PPGGGSNGGT PFGDPASATA
SSDTSGTWAA VGYGAAAVAY CRYLALSYSH DGAARPEDVL PVLLQLLHVA MRHAAPIEQL
LEVQLMAVPP PAWFAITPQL LAQLPGSSGA ARRLLGLLLH AVGRAAPSLV LYPAVIEMRT
ADAAAAVAAA GGGAAIIRSD GNDADGSGTD PSVTATGCAS MIPELRALLA DLGRSRPRLL
ADVEVLVAEM ERLTVLWDER WAALLAEVEV EIARRAVSLQ AEAARVADDA SMTAEQRQAL
LSSRYSTLMA PAVMLLERQL RATAAMPPET PHERWFATSV LPRLRAAAAS LRDGAGVCDW
ARPSQAWAPL RAAAATLARQ QRQPLPPMSQ LSPRLAALQD SEVPMPGCHA DGSASGALMP
SGLIAQPPAA RLSDIAAASG DLTSAGWGSA TVTVASVYSE LVALNTKTRP KRVALLGSDG
RTYAYLLKGR EDLRMDERLM QVLRAINVML QADPAAACQG LATVRCYSVT PLGPRAGLIQ
WVPATTSLFG VFREWQTATL ERNAAMVTAR QEGVAKALAE GASPPPEVEP PPPAAANRPM
DLFYSRLVSA LQDRGLSSAT PRRSWPTDLL RAVFCSLAAS APKQLLARVL WAGGGSAALA
WRRQQRYSRS LAVMSCVGYL LGLGDRHPDN ILLEGREAGV VHIDYNVCWE KGAKLRVPEV
VPFRLTQMLR TALGVGGLEG VFRTACEATF GCLRRHREAL VGLADAVLSD PGVDWAVERE
EMAARQDMEL AVALNLFVSR AEEAQRQLQQ AEEELPAVLE GPVGVLLSYM EAQVFAEAMR
NASTEAQQRI QEAKSALEAA KRAETEASAI VAAAAQEAAS LAAEGNALSN AVPQLLQQCG
DWAQQHAGTL GVLRDGSFLE GTLASGASWR AVESGCVLGL LGPVQGPGHA PLAAAAPLAL
MSAIMGGDSI AIGQLPEELL HSCYECDRQA ADVLGNREAA LNDAVGALTQ YGTIVRKLLP
PSYPASSYHH RWAQALAALA AGGLSMPAVA QAQALAPREP RPLDVATAWQ ALRGAQRLAT
AAAIVLAPGS PDAAVAMSGY VAGVRVSGRE LAGAVAAAGK AFGNAMAGVV VEAQERQAAA
ATTSVGRTVN PVGLSVPHLT RGLVELLQRH IPARPKSELG APGDEAGHHG VSASTSAAMA
ASSTALLKLV RAANGRVEAL GNYTGQQHDF SQTKEISGGF AALLQDFLRV RGEVAGLAAV
TAALAGTELA APVLGVADLA FGASCGDGSA SPSLLPHPYH YQHHRRFHQG DCPSPYMISG
DATPDLCGDN GANAARCPLP WLSAAADACG RWPELMQCLA ADVAPELAGQ LHVGSGSVGA
GDTGGGGMAG SAAAPPNTPI AQAAADLRAL LRPIEESLQA GRDAHTRLGA LAELTATYHG
RRAELVCRLT GNGANGSAML GDWDDSPALP STQLTTPERE SLEADLRALD AAWASRDAVA
AGLSAAAAMA TDALVVALRG LYTAVLGPGR VPIELQTYDA AAAMYVSASG VEGWAEAGSG
GHVAVAAMVA WWDAVTESLE GIRQYDDGKL GGAGGGSAAL GPAGSHFGVP PMMWQLYRCV
EVAQLVEQSL RTCGQALRLV APAGTDGALA DAYSIVMQVL TRQATEHAAS RMSTHFNHFL
TSMEAHLTAS LEHCKPPTVM DHSHDGSTST GAGSVEAGDG GAAGSSSRTV GADWDKGAPD
LVPFTDFDPG VAGEGEVLGG LEDEDDKAPD GSGGSSDDNA AWFDYDDEPG HNGGGLCGDD
DHGYDLDLGL DLDLDDGFGD GSEDVEERRG GGFDGTSHGE GSGRGPDSDM DSRQGRRRVS
KAQPPIPSLP EEVSTLVECL AACAAAAAVA SGVAAIDPAS QPPAMAFAIT WAAGAEARAA
RAARLQRLAA YEWMHEHHLL QVLPTGDPRI GQALAQFFAA QAADPLQPSA RVTSASRLSL
LTQLQSALDA LPQLEQAVSG WEASSNDAVS QVVAVLRTAP ERYPVDTALA AQRAGMLMGR
RQQWLGESRG VVMRVCQVSE ALLQFEYSRQ GITWSSGTAA VADGFATHCQ LLGRAEVLAT
LAAGGSEAGR AAAVAEASQR ATEAARQAAD ARYALEVAQY EEVAASSQLQ AHLPQLVARS
LDLAEAVAES ESVVKGLVHL LSNKLGPALK ELSSVTAQHS AASDVASVTA SVAAHYKRSY
QAVEALAAVL PSTLASLTAA DAASPLPVEM ATEVGFLSAQ LLGGPAAAAE TRKRAMALLQ
HMTAPTAALQ PVAHTVLELP RALGQLRNEL NILAAAAGSI AAAVESKHLL PVLDEQPQQQ
VQEQGRSRGH TPPQVPSAGA SDTPSDTADG TQSRTAADAE VIGTSQTEAL GQGGIAPEPG
ICAAKAASVT PTSTAGTGGL VRLPLQRLVH AAAADHLQHH RSRRSAANEA RRRAFAASAL
RRFIAKLEGR ESEGAAAGLV SGAASAASAQ QQHLSVSDQV DLLVRQATSV DRLSQMYEGW
TAWL
//
