ID A0A8J4KV85_EUDCH Unreviewed; 436 AA.
AC A0A8J4KV85;
DT 25-MAY-2022, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 1.
DT 28-JAN-2026, entry version 12.
DE SubName: Full=Suppressor of cytokine signaling 4 {ECO:0000313|EMBL:KAF1649916.1};
DE Flags: Fragment;
GN Name=SOCS4 {ECO:0000313|EMBL:KAF1649916.1};
GN ORFNames=FQV12_0013416 {ECO:0000313|EMBL:KAF1649916.1};
OS Eudyptes chrysocome (Western rockhopper penguin) (Aptenodytes chrysocome).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Aequornithes; Sphenisciformes;
OC Spheniscidae; Eudyptes.
OX NCBI_TaxID=79626 {ECO:0000313|EMBL:KAF1649916.1, ECO:0000313|Proteomes:UP000716595};
RN [1] {ECO:0000313|EMBL:KAF1649916.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=RH 110-1 {ECO:0000313|EMBL:KAF1649916.1};
RX PubMed=31531675; DOI=10.1093/gigascience/giz117;
RA Pan H., Cole T.L., Bi X., Fang M., Zhou C., Yang Z., Ksepka D.T., Hart T.,
RA Bouzat J.L., Argilla L.S., Bertelsen M.F., Boersma P.D., Bost C.A.,
RA Cherel Y., Dann P., Fiddaman S.R., Howard P., Labuschagne K., Mattern T.,
RA Miller G., Parker P., Phillips R.A., Quillfeldt P., Ryan P.G., Taylor H.,
RA Thompson D.R., Young M.J., Ellegaard M.R., Gilbert M.T.P., Sinding M.S.,
RA Pacheco G., Shepherd L.D., Tennyson A.J.D., Grosser S., Kay E., Nupen L.J.,
RA Ellenberg U., Houston D.M., Reeve A.H., Johnson K., Masello J.F.,
RA Stracke T., McKinlay B., Borboroglu P.G., Zhang D.X., Zhang G.;
RT "High-coverage genomes to elucidate the evolution of penguins.";
RL Gigascience 8:0-0(2019).
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF1649916.1}.
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DR EMBL; VULL01001375; KAF1649916.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A8J4KV85; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000716595; Unassembled WGS sequence.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd10385; SH2_SOCS4; 1.
DR CDD; cd03738; SOCS_SOCS4; 1.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR035864; SOCS4_SH2.
DR InterPro; IPR037342; SOCS4_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF21; SUPPRESSOR OF CYTOKINE SIGNALING 4; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000716595};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 282..377
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 372..421
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 180..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KAF1649916.1"
FT NON_TER 436
FT /evidence="ECO:0000313|EMBL:KAF1649916.1"
SQ SEQUENCE 436 AA; 49751 MW; CAAA87C907560187 CRC64;
MAENKDSNIK NADVRPKSSR SRSADRKDGY VWSGKKLSWS KKSEHCSDAE TASAAGRSGT
NLRSQERKYS CSSVELDLDR SCGHRFLGRS LKQKLQDAVG QCFPIKNCSS RHTSGLPSKR
KIHISELMLD KCPFPPRSEL AFRWHLIKRH TAPISPKAED WIIADLSQHE EREDQLRDDE
IANGGTDSPS QSCDFTDSGS SRGDSRSELA TGKVVRSSKD ESDMDSDDEV ITLCTSSRKR
NKPKWETDDE LLRMETPPKY HTQIDYVHCL VPDLLQINNN PCYWGVMDKY AAEALLEGKP
EGTFLLRDSA QEDYLFSVSF RRYSRSLHAR IEQWNHNFSF DAHDPCVFHS PDITGLLEHY
KDPSSCMFFE PLLSTPLNRT FPFSLQHICR TVICNCTTYD GIDALPIPPS VKLYLKEYHY
KSKVRVLRID VPEQQS
//
