ID A0A8J5D515_CHIOP Unreviewed; 1596 AA.
AC A0A8J5D515;
DT 25-MAY-2022, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 1.
DT 18-JUN-2025, entry version 17.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN Name=ankib1 {ECO:0000313|EMBL:KAG0729195.1};
GN ORFNames=GWK47_030836 {ECO:0000313|EMBL:KAG0729195.1};
OS Chionoecetes opilio (Atlantic snow crab) (Cancer opilio).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Brachyura;
OC Eubrachyura; Majoidea; Majidae; Chionoecetes.
OX NCBI_TaxID=41210 {ECO:0000313|EMBL:KAG0729195.1, ECO:0000313|Proteomes:UP000770661};
RN [1] {ECO:0000313|EMBL:KAG0729195.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MADBK_172401_WGS {ECO:0000313|EMBL:KAG0729195.1};
RC TISSUE=Digestive gland {ECO:0000313|EMBL:KAG0729195.1};
RA Jeong J.-H., Ryu S.;
RT "The High-quality genome of the commercially important snow crab,
RT Chionoecetes opilio.";
RL Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
CC -!- SIMILARITY: Belongs to the RBR family. Ariadne subfamily.
CC {ECO:0000256|ARBA:ARBA00005884}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAG0729195.1}.
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DR EMBL; JACEEZ010001461; KAG0729195.1; -; Genomic_DNA.
DR OrthoDB; 69641at2759; -.
DR Proteomes; UP000770661; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd20346; BRcat_RBR_ANKIB1; 1.
DR CDD; cd20361; Rcat_RBR_ANKIB1; 1.
DR FunFam; 1.25.40.20:FF:000040; RBR-type E3 ubiquitin transferase; 1.
DR FunFam; 3.30.40.10:FF:000019; RBR-type E3 ubiquitin transferase; 1.
DR Gene3D; 1.20.120.1750; -; 2.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR031127; E3_UB_ligase_RBR.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR047564; Rcat_RBR_ANKIB1.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01485; IBR; 1.
DR Pfam; PF22191; IBR_1; 1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00647; IBR; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000770661};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT REPEAT 45..78
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 133..165
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 327..571
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 331..382
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1238..1267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1314..1334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1520..1596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1525..1540
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1541..1567
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1568..1581
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1596 AA; 176777 MW; 83FF52418CE3FFC9 CRC64;
MGSASSKFKK YLQHGDEFAA MQVFQSSPEL RSNLDPSASY GESHSHNTPL HYAARHGMKH
LLRTFLSDLG GNPNKKNADD ETAVHCVCRV GQAKSPSAED RRAACIVMIL QWRGPLLQDG
EKERVQLNAQ DKKGNTALHY SSASGLQKCV ELLVAQGAGL FVENRDRLTP CDLAVRLAHH
DVATYLESCM VFADSCDGIN ESELIGHDGE ADGDNEVYSG LRAQDLQEAK DQLLVETADM
LHIPLFTAEA LLRDNEWSKA LLLEKWMTNA VQCCEEAGIA PPASALQLVA SSPPLLSPSP
PCSVISPPLP PHIPAGLGEQ DEGGREGKNL CEICYGEMRC WELQEHGGAS CQHQFCATCW
ESYLSLKIQE GGAHHILCPA VRCNILVDVD FIEKMVSPEI ARKYLQFDIQ AFVDRNKTIK
WCPLPGCGRA VKFPEAELET QPFYFPNTKP PPKTSHAVDC GNGHFFCWEC LGEAHSPSGC
EQWVEWQGKV AEVKPEELRI SSGETEDAAN FLWLVTNSKP CPNCKSPIQK NEGCNHMKCS
KCKFDFCWVC LESWKKHSSA TGGYFRCNRF DAQGKADEKL GVMLSEVSVV LVLVLLVVLV
LLLPPPLLCY GHSCCCCCCC CRCLAANLNA MLSCNTYFKY TFRTTLVAII RTFVLLCDGV
EQATMRNHQM QELNRFIHYY TRFKNHQNSL KMEEPLLKSA RDKMEVLATS LPSQEQQGQG
RSWEVKVKGG RMGGREATER EREYDRDISF NVSCVLTASV EKGTRFVEEG VKELLKARRV
LCGSYVYGYY LEDNGYNKTI FEYMQNELEE VTEKLSEMVA RQYLVTPRRQ IIATTLLARR
RRHKFVRAVS RGLLPPETPP ALRRARKRRL PGLVGMDPPD DQMENVEAMG RTLDPSQPWV
KDSRGCHTNL AALLDWPDLD SDEEESSLNQ ALTLTLLGKC NRKSCPRPRA RNPRTGTIHD
YCSLHCAQRA KYLPEQVVPP LSTSLPLTTS SLPYPSPGDG EPSSSSSWEV CDSSMELLIA
LEMSRLQMIE DEARRRLSWL QEHSREQGWD GAGDARPHQG CIEVPVVPGT SVAGSSIFTY
EVACGSRGQG GGGGGHSEAS AWIRPELGEG AISFQPSSAE IAVDYFLKKL ANKEISQRNL
NVEKHWAENK KVEKDLLCFP NASTPGEMED GLFLYGDLHE NSRLLPPIDL RRDLRRSQSL
GDLKSCEESL CLFDADHAHL DHPEETLRRQ FAAAAAAARA SMEDEGTESG GDVENTDPGG
ASEIIGDMDS PLMDLEVRGI LSHLEECSGN VAGGEGSGGV AGQEPSFQLV VDEGTDKDES
NSTEQSSSAP AANIKGLRIH ISHSNKLEGQ SSNEYESETG IPNSPTLYIS GVSICRSPEP
RSPKVHHREA RSPSLTLPLC CTPEPRLRLE GRLDTSPLPI YSRSRSSSLV VPSSSNFSPR
VCARASGTSL HLSSISLQAT RATSPFLTGE LRVTRSASET EKGRLVFQFP KSPTDGALSS
VLHVEESNLS SDDFHEALFL GKSPKPVKKK RSKNDRKKGA KERSKGERRE KKEARGRTKA
RTMEKRGKKE KIARKREKVK RSPPLYDAEN TEALKW
//
