ID A0A8J6A6U8_GALPY Unreviewed; 679 AA.
AC A0A8J6A6U8;
DT 25-MAY-2022, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 1.
DT 28-JAN-2026, entry version 16.
DE RecName: Full=YTH domain-containing family protein {ECO:0000256|RuleBase:RU369095};
DE Flags: Fragment;
GN ORFNames=J0S82_018579 {ECO:0000313|EMBL:KAG8513252.1};
OS Galemys pyrenaicus (Iberian desman) (Pyrenean desman).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Talpidae; Galemys.
OX NCBI_TaxID=202257 {ECO:0000313|EMBL:KAG8513252.1, ECO:0000313|Proteomes:UP000700334};
RN [1] {ECO:0000313|EMBL:KAG8513252.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IBE-C5619 {ECO:0000313|EMBL:KAG8513252.1};
RX PubMed=34295371;
RA Escoda L., Castresana J.;
RT "The genome of the Pyrenean desman and the effects of bottlenecks and
RT inbreeding on the genomic landscape of an endangered species.";
RL Evol. Appl. 14:1898-1913(2021).
CC -!- FUNCTION: Specifically recognizes and binds N6-methyladenosine (m6A)-
CC containing RNAs, and regulates mRNA stability. M6A is a modification
CC present at internal sites of mRNAs and some non-coding RNAs and plays a
CC role in mRNA stability and processing. {ECO:0000256|RuleBase:RU369095}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC {ECO:0000256|ARBA:ARBA00004201}. Cytoplasm, Stress granule
CC {ECO:0000256|ARBA:ARBA00004210}.
CC -!- SIMILARITY: Belongs to the YTHDF family.
CC {ECO:0000256|RuleBase:RU369095}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAG8513252.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JAGFMF010011769; KAG8513252.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A8J6A6U8; -.
DR OrthoDB; 306690at2759; -.
DR Proteomes; UP000700334; Unassembled WGS sequence.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:UniProtKB-SubCell.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR GO; GO:0003729; F:mRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:1990247; F:N6-methyladenosine-containing RNA reader activity; IEA:UniProtKB-UniRule.
DR GO; GO:0061157; P:mRNA destabilization; IEA:TreeGrafter.
DR CDD; cd21134; YTH; 1.
DR FunFam; 3.10.590.10:FF:000001; YTH domain family 1, isoform CRA_a; 1.
DR Gene3D; 3.10.590.10; ph1033 like domains; 1.
DR InterPro; IPR007275; YTH_domain.
DR InterPro; IPR045168; YTH_prot.
DR PANTHER; PTHR12357:SF65; YTH DOMAIN-CONTAINING FAMILY PROTEIN 1; 1.
DR PANTHER; PTHR12357; YTH YT521-B HOMOLOGY DOMAIN-CONTAINING; 1.
DR Pfam; PF04146; YTH; 1.
DR PRINTS; PR00049; WILMSTUMOUR.
DR PROSITE; PS50882; YTH; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000700334};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU369095}.
FT DOMAIN 456..590
FT /note="YTH"
FT /evidence="ECO:0000259|PROSITE:PS50882"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 308..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..322
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..380
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KAG8513252.1"
SQ SEQUENCE 679 AA; 71450 MW; 519C703DEA645396 CRC64;
HRVRVGCQKH SPEPGLATSP VQNGSLHQKD AAQDSDFEPY LSGQSNQVSL RCFQHTLASE
LAWLSAGHQC CRSLLVTARA RAGRRSAAHR GSRLRLHLPC CRRRGLCLPR LSPQSSSYPS
MADPYLSSYY PPSIGFPYSL SEAPWSTGGD PPIPYLTTYG QLSNGDHRFM HDAVFGQPGG
LGSNIYQHRF NFFPENPAFS AWGAGGSQGQ QAQGSAYGSS YACPPSSLGG TVVDGQAGFP
SDTLSKAPGV NSLEQGMVGL KLGDVTAAAV EAAGSGIGSA AVAGVLAGGG AGGGLPVSKP
TSWAAIASKP AKPQPKAKAK AGPGVGGAPP PPPIKHNMDI GTWDNKGPVP KASAAQPTPA
PQAAPQPLPA AQPLPAPPLA QPQCQGPRQP PPARWVAPRS RSAAFGPSGG SGGDRDSPGG
VQLGAAPGGE PHPVLEKLKA AHSYNPRGFD WRLKSGRVFI IKSYSEDDVH RSIKYSIWCS
TEHGNKRLDS AFRATGSKGP VYLLFSVNGS GHFCGVAEMK SPVDYGTSAG VWSQDKWKGK
FDVQWIFVKD VPNNQLRHIR LENNDNKPVT NSRDTQEVPL EKARQVLRVI ASYKHTTSIF
DDFSHYEKRQ EEEEAVRKVS GSARAGGRLR GLCGPGPRAL GLSVGPLRHA GPGSGVHILS
LHSPDGLFWG AGAGSRAGL
//
