ID A0A8J6DLU6_GALPY Unreviewed; 192 AA.
AC A0A8J6DLU6;
DT 25-MAY-2022, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 1.
DT 02-APR-2025, entry version 12.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
DE Flags: Fragment;
GN ORFNames=J0S82_015188 {ECO:0000313|EMBL:KAG8510983.1};
OS Galemys pyrenaicus (Iberian desman) (Pyrenean desman).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Talpidae; Galemys.
OX NCBI_TaxID=202257 {ECO:0000313|EMBL:KAG8510983.1, ECO:0000313|Proteomes:UP000700334};
RN [1] {ECO:0000313|EMBL:KAG8510983.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IBE-C5619 {ECO:0000313|EMBL:KAG8510983.1};
RX PubMed=34295371;
RA Escoda L., Castresana J.;
RT "The genome of the Pyrenean desman and the effects of bottlenecks and
RT inbreeding on the genomic landscape of an endangered species.";
RL Evol. Appl. 14:1898-1913(2021).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAG8510983.1}.
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DR EMBL; JAGFMF010011860; KAG8510983.1; -; Genomic_DNA.
DR OrthoDB; 10009520at2759; -.
DR Proteomes; UP000700334; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd20367; BRcat_RBR_RNF144B; 1.
DR CDD; cd20369; Rcat_RBR_RNF144B; 1.
DR FunFam; 1.20.120.1750:FF:000010; RBR-type E3 ubiquitin transferase; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR InterPro; IPR031127; E3_UB_ligase_RBR.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR Pfam; PF01485; IBR; 1.
DR Pfam; PF22191; IBR_1; 1.
DR SMART; SM00647; IBR; 2.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000700334};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT TRANSMEM 147..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..133
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT NON_TER 192
FT /evidence="ECO:0000313|EMBL:KAG8510983.1"
SQ SEQUENCE 192 AA; 21319 MW; 9A2B9DDD2EBE7D3B CRC64;
VHLDPYRTWC PVADCQTVCS VAPSDPGKPV PVECPSCHLK FCSCCKDAWH AEVSCRDSQP
VVLPTEHGIL FGTDAEAPIK QCPVCRVYIE RNEGCAQMMC KNCKHTFCWY CLQNLDNDIF
LRHYDKGPCR NKLGHSRASV MWNRTQVVGI LVGLGIIALV TSPLLLLASP CIICCVCKSC
RGKKKKHDPP TT
//
