ID A0A8J6F3P3_ELECQ Unreviewed; 427 AA.
AC A0A8J6F3P3;
DT 25-MAY-2022, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 1.
DT 28-JAN-2026, entry version 10.
DE RecName: Full=Suppressor of cytokine signaling 4 {ECO:0008006|Google:ProtNLM};
GN ORFNames=GDO78_010594 {ECO:0000313|EMBL:KAG9481448.1};
OS Eleutherodactylus coqui (Puerto Rican coqui).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Hyloidea; Eleutherodactylidae;
OC Eleutherodactylinae; Eleutherodactylus; Eleutherodactylus.
OX NCBI_TaxID=57060 {ECO:0000313|EMBL:KAG9481448.1, ECO:0000313|Proteomes:UP000770717};
RN [1] {ECO:0000313|EMBL:KAG9481448.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HN-11 Male {ECO:0000313|EMBL:KAG9481448.1};
RC TISSUE=Kidney and liver {ECO:0000313|EMBL:KAG9481448.1};
RA Mudd A.B.;
RT "Comparative Genomics and Chromosome Evolution.";
RL Thesis (2020), ProQuest LLC, 789 East Eisenhower Parkway, Ann Arbor, MI,
RL USA.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAG9481448.1}.
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DR EMBL; WNTK01000006; KAG9481448.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A8J6F3P3; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000770717; Unassembled WGS sequence.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF21; SUPPRESSOR OF CYTOKINE SIGNALING 4; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000770717};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 272..367
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 362..411
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 427 AA; 48792 MW; 429C9F88C3A9E20A CRC64;
MAENIEEKLG DLDVRPKSSR SRSADRKDGY VWSGKKLSWS NKSGHLADGD AVCDTDKAEG
SSRSQEIKHS CSSIELDLDR SCGQKLLGRS LKQKLQDAVG QCFPIKMCSS RHQSVLSSKR
KIHISELMLD KCPFPPKSDL AYRWHFIKRH TVPVSQPHTQ YVVKDSPKVE LLAMADGEED
SMSEEQVLSC EVNIGTVESV TTKALRSNKE DSDIDSDDEV LTICASSRKR NKPKWEPDDE
IFLAATPPKY HTQIDYVHCL VPDLFQINNN SCYWGVMDRY AAEALLEGKP EGTFLLRDSA
QEDYLFSVSF RRYSRSLHAR IEQWNHNFSF DAHDPCVFHA PNITCLLEHY KDPSSCMFFE
PLLSSPLHRT FPFSLQHISR TVICSSTNYD GIDALPVPSS MKLYLKEYHY KSKVRVRRVD
IPERHHK
//
