ID A0A8J6K8W7_ELECQ Unreviewed; 1292 AA.
AC A0A8J6K8W7;
DT 25-MAY-2022, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 1.
DT 10-JUN-2026, entry version 16.
DE RecName: Full=Rho GTPase-activating protein SYDE2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=GDO78_009077 {ECO:0000313|EMBL:KAG9482930.1};
OS Eleutherodactylus coqui (Puerto Rican coqui).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Hyloidea; Eleutherodactylidae;
OC Eleutherodactylinae; Eleutherodactylus; Eleutherodactylus.
OX NCBI_TaxID=57060 {ECO:0000313|EMBL:KAG9482930.1, ECO:0000313|Proteomes:UP000770717};
RN [1] {ECO:0000313|EMBL:KAG9482930.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HN-11 Male {ECO:0000313|EMBL:KAG9482930.1};
RC TISSUE=Kidney and liver {ECO:0000313|EMBL:KAG9482930.1};
RA Mudd A.B.;
RT "Comparative Genomics and Chromosome Evolution.";
RL Thesis (2020), ProQuest LLC, 789 East Eisenhower Parkway, Ann Arbor, MI,
RL USA.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAG9482930.1}.
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DR EMBL; WNTK01000005; KAG9482930.1; -; Genomic_DNA.
DR OrthoDB; 120383at2759; -.
DR Proteomes; UP000770717; Unassembled WGS sequence.
DR GO; GO:0097060; C:synaptic membrane; IEA:TreeGrafter.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0016477; P:cell migration; IEA:TreeGrafter.
DR GO; GO:0046578; P:regulation of Ras protein signal transduction; IEA:TreeGrafter.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR FunFam; 1.10.555.10:FF:000031; rho GTPase-activating protein 100F isoform X6; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR052118; Rho-GAP_regulator.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR057459; SYDE1/2_C2.
DR PANTHER; PTHR46150; RHO GTPASE-ACTIVATING PROTEIN 100F; 1.
DR PANTHER; PTHR46150:SF1; RHO GTPASE-ACTIVATING PROTEIN SYDE2; 1.
DR Pfam; PF25336; C2_SYDE; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00172}; Reference proteome {ECO:0000313|Proteomes:UP000770717}.
FT DOMAIN 776..895
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 932..1147
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 159..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 297..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 465..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 592..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 715..767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1149..1172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1224..1261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..184
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..497
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 498..509
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..652
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 725..740
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..763
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1230..1248
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1292 AA; 142439 MW; FB619742296C4314 CRC64;
MGCYSFRGHQ PLKAPHSAPY SLSPDFEEHW RAPSPLNFIY PPLPESSVPR DRFFTPGGNA
VHCRHPPLAL AGGSFYGGIR NHSEDSEEDD YYDNENLLLS SAGTEVLSSR TPFTHRTAAA
DDRKGGLEVY LETDRLRSQL QEAYYLLIHA MHDMPLESHT RKTGARLETC PSSSQSQDSV
YSQSSARVVE SDVWSSDEAS PKQVSRSDLA SLNALMTAQQ LNRIRRISKS ADTVYNLPAA
EPLHKCHSDS RVKYSPINSS LSSECGYQHS QGSIGHQADV DSCEGSPRDA LATVHWRASE
GGIERRPEMP GTSRNDDEDA VMVEDSGSSS TKPSGLTVKK MQKWMYKGRL LSLEVKERLI
GSSQKAGGGG GFGKSEASHT GNKSELLQDK SDLIENTYTS AVIRRDLKVT EVNQHNLQNN
HITVSKKRNW LTQSSHRHHH VTDGHKRSYY TSNSSHVVIR ETVLQLSRPD RDVPSRAQET
VPSTQLSPQA LPTGTSDLSE DNDADDEGEI WYNPIPEDDE PYVSLKTSSD LTVPEPGRDV
PEVPARQGCL PGAGEPLSPA ADDNGDSLDS TDYGGQLCKQ RFVCKTATSL STEEPPACGS
HDSGSRVISP APVDFSPPCS PNPVKKGGSI NWSLPDKIKS PRTVRKLSMK MKKLPELSRK
LSVKGTSWSH SNADHQSKGN GQEVGHAAPL SPSGQAAAAA SRNVISRYHL DSSVSSQHSY
KKKSSGPSKS SSKGGYLSDG DSPELITKSG KHGAEGRSTK GKECPATNNA KTELDIDAFR
HYSFSDQPKC FQFVSGLMSA HFYGAEDLKP PRIDSKDVFC AIQVDSVNKA RTALLTCRTS
FLDMDHTFNI ELENAQHLKL VVFSWDPTPK KNRVCCHGTI ILPALFRVTK THQLAVKLEP
RGLIYVKLSL MEQWENSADR LGGDREPVMF GVDARQIVEK ENSGLMVPLL MDKCIMEIEK
RGCQVVGLYR LCGSAAVKKE LREAFERDSK SVSLCENDYP DINVITGVLK DYLRELPSPL
ITKQLYEAVL HAMAEKPLRM SGNGCENDPR DSEQTVELLI CLPDVERATL KMLLDHLKLV
ASYHEVNKMT CQNLAVCFGP VLLSQRQETS NHNNRVFIDS EELASALDFK KHIEVLHYLL
QLWPVKNESS KEAPPSNVQT EPQPCLRRKK PRPQMLNLNS LEMSGVLRPR AARLDSPSSN
RYAGDWSSCQ GSYLITPKEE ADCASAVSES PRETTEGTSE HLKAKEHPLC TPITDGGSGE
QDVNLHDLQE SIDTLIGNLE RELSKNKLSA AM
//
