ID A0A8J7FI27_9GAMM Unreviewed; 775 AA.
AC A0A8J7FI27;
DT 25-MAY-2022, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 1.
DT 18-JUN-2025, entry version 16.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00044770};
DE EC=2.4.99.28 {ECO:0000256|ARBA:ARBA00044770};
GN Name=pbpC {ECO:0000313|EMBL:MBE9398048.1};
GN ORFNames=IOQ59_12340 {ECO:0000313|EMBL:MBE9398048.1};
OS Pontibacterium sinense.
OC Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC Oceanospirillales; Oceanospirillaceae; Pontibacterium.
OX NCBI_TaxID=2781979 {ECO:0000313|EMBL:MBE9398048.1, ECO:0000313|Proteomes:UP000640333};
RN [1] {ECO:0000313|EMBL:MBE9398048.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=N1Y112 {ECO:0000313|EMBL:MBE9398048.1};
RA Chen R.-J., Lu D.-C., Zhu K.-L., Du Z.-J.;
RT "Bacterium isolated from coastal waters sediment.";
RL Submitted (OCT-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans,octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.99.28;
CC Evidence={ECO:0000256|ARBA:ARBA00049902};
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004752}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the transpeptidase
CC family. {ECO:0000256|ARBA:ARBA00007090}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the
CC glycosyltransferase 51 family. {ECO:0000256|ARBA:ARBA00007739}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MBE9398048.1}.
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DR EMBL; JADEYS010000012; MBE9398048.1; -; Genomic_DNA.
DR RefSeq; WP_193953687.1; NZ_JADEYS010000012.1.
DR UniPathway; UPA00219; -.
DR Proteomes; UP000640333; Unassembled WGS sequence.
DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:TreeGrafter.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR050396; Glycosyltr_51/Transpeptidase.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR011815; PBP_1c.
DR InterPro; IPR009647; PBP_C.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; TIGR02073; PBP_1c; 1.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF15; PENICILLIN-BINDING PROTEIN 1C; 1.
DR Pfam; PF06832; BiPBP_C; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 3: Inferred from homology;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000640333};
KW Transferase {ECO:0000256|ARBA:ARBA00022676}.
FT DOMAIN 46..223
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 299..524
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT DOMAIN 685..771
FT /note="Penicillin-binding C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06832"
SQ SEQUENCE 775 AA; 86506 MW; 05BA4367A2740FC2 CRC64;
MKRLRRLVIG VAVSVALVAG LFGSLDRLYP MAPIPAVSTV VLAEDGTPLR AFPGANHQWR
YPVTLEQVSP TYLELLLAYE DRWFYQHPGV NPLALLRAGW QNLRSERVLS GGSTLTMQVS
RLLYPHARSY LGKLSQILRA LQLEWHYSKA EILSIYLNIA SFGGTLSGVQ AASYYYFDKP
ALQMSDAEAA LLAVLPQRPS DYRPDRHPQR ARQARDKVLQ RMQSLGLWSL QRINDARQEP
VSTFAQGMPN VAPLLARRLY QDCTDCRTIN TTLDYDLQIQ LERLVDQYTE SLSEEHSVAV
MVMRNRDGAV RSYIGSADFW SQKRAGQVDI IQAVRSPGST LKPFLYGFAL DEGLIHSHSL
LIDAPRFKSQ YRPQNFSGFF NGPVTATSAL QRSLNVPAVQ LIEHFGADRF VTRLQNGGLK
TFGPGSAKPN TSVILGGIGV QLESLLGIYS ALARDGKAIS PRFQTDSPKQ ERYLMSSGAA
WIIRDMLAQH PYRRIGQHTR KEWDLAWKTG TSYGYREAWA MGVSPDWSIG VWVGRPDGSA
SPGRYGRVTA APLLFRVHAA LPSSEAEHPQ QPESVSRQTI CWPAGTQHTR RENTAPNCLK
RYDAWLLNDT APATLPETSE LTLQKQVNQI WLDPVSGKRA EPACLPGHTL EPALIALWPE
AVDPWLPRHW QNQHRLPPLD ARCQRSSGAA EAPLHITSWP TDALLQLPGA HRTEALDIML
NAEGGSGYRD WYLNGGYIGR SQNGLPYQLT QAGRYQISVV DQQGNMDRVD IRVLP
//
