ID A0A8J7LXP2_9BACT Unreviewed; 694 AA.
AC A0A8J7LXP2;
DT 25-MAY-2022, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 1.
DT 18-JUN-2025, entry version 16.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00044770};
DE EC=2.4.99.28 {ECO:0000256|ARBA:ARBA00044770};
GN Name=pbpC {ECO:0000313|EMBL:MBJ6723451.1};
GN ORFNames=JFN93_01905 {ECO:0000313|EMBL:MBJ6723451.1};
OS Geomesophilobacter sediminis.
OC Bacteria; Pseudomonadati; Thermodesulfobacteriota; Desulfuromonadia;
OC Geobacterales; Geobacteraceae; Geomesophilobacter.
OX NCBI_TaxID=2798584 {ECO:0000313|EMBL:MBJ6723451.1, ECO:0000313|Proteomes:UP000636888};
RN [1] {ECO:0000313|EMBL:MBJ6723451.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Red875 {ECO:0000313|EMBL:MBJ6723451.1};
RA Xu Z., Zhang Z., Masuda Y., Itoh H., Senoo K.;
RT "Geomonas sp. Red875, isolated from river sediment.";
RL Submitted (DEC-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans,octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.99.28;
CC Evidence={ECO:0000256|ARBA:ARBA00049902};
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004752}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the transpeptidase
CC family. {ECO:0000256|ARBA:ARBA00007090}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the
CC glycosyltransferase 51 family. {ECO:0000256|ARBA:ARBA00007739}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MBJ6723451.1}.
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DR EMBL; JAEMHM010000002; MBJ6723451.1; -; Genomic_DNA.
DR RefSeq; WP_199382301.1; NZ_JAEMHM010000002.1.
DR UniPathway; UPA00219; -.
DR Proteomes; UP000636888; Unassembled WGS sequence.
DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:TreeGrafter.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR050396; Glycosyltr_51/Transpeptidase.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR011815; PBP_1c.
DR InterPro; IPR009647; PBP_C.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; TIGR02073; PBP_1c; 1.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF15; PENICILLIN-BINDING PROTEIN 1C; 1.
DR Pfam; PF06832; BiPBP_C; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 3: Inferred from homology;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000636888};
KW Transferase {ECO:0000256|ARBA:ARBA00022676}.
FT DOMAIN 34..197
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 291..510
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT DOMAIN 611..687
FT /note="Penicillin-binding C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06832"
SQ SEQUENCE 694 AA; 75765 MW; 1559BCEE8CBD3E8D CRC64;
MSTISAQAAL LPTFSEVQKA HRRSDVLILD RHGELIHELR VDKTGRRLEW TKLKDVSPAL
VKAVLQSEDR RFYEHGGVDW KAVGAALIDR FFGSKTRGAS TISMQVAVMV QRGGRPLGHK
TFRQKWDQMA AARELEKSWK KDEILEAYLN LVSFRSELQG IAAASRGLFG KEPSGLDLKE
SCTLAALIRS PNALPAVVGQ RAALLAQSLS PGEPGEAYRR TAIDALSRPY RLRPYLALAP
QVAKILTAGA GQGELSAQTI NSTLDLRLQR FALQSLRQQL DLLQGRHVGN GAVLVVDNAT
GNILAYVGNS GDSQVDGIVA KRQAGSTLKP FLYGLALEKR LLTTASVLDD TPLHISTERG
IYMPHDYDHR PRGPVTVRTA LSASLNIPAV RTQLLVGTEP FADRLRRVGF DLRRSAEFYG
FSLALGTADV SLKELVNAYR CIARGGIVSP LHLTPGHSGR TLRAMDPKVA YLVSDILSDP
GSRSVTFGLD NPLTTRYWTA VKTGTSKDMR DNWCIGFSRR YTVGVWVGNL SGDPMWNVSG
VSGAAPVWLE VMNYLHGNVR SAPPPRPRGV VAARVPAGHG EAERGELFLA GTEPPSVPAA
RPAGEAWHIA RIAYPPDGTI IVIDPDIPEP NQRVFFETEN EAPGLKWRLN GELLPPGEEG
RRWAPRVGRY ELALVDNGGK VQDAVSFEVR GQNQ
//
