ID A0A8J7P9J3_ATRSP Unreviewed; 460 AA.
AC A0A8J7P9J3;
DT 25-MAY-2022, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 1.
DT 28-JAN-2026, entry version 12.
DE SubName: Full=SOCS5 protein {ECO:0000313|EMBL:MBN3326034.1};
DE Flags: Fragment;
GN Name=Socs5_0 {ECO:0000313|EMBL:MBN3326034.1};
GN ORFNames=GTO95_0009118 {ECO:0000313|EMBL:MBN3326034.1};
OS Atractosteus spatula (Alligator gar) (Lepisosteus spatula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Atractosteus.
OX NCBI_TaxID=7917 {ECO:0000313|EMBL:MBN3326034.1, ECO:0000313|Proteomes:UP000736164};
RN [1] {ECO:0000313|EMBL:MBN3326034.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Allg_001 {ECO:0000313|EMBL:MBN3326034.1};
RX PubMed=33545088;
RA Bi X., Wang K., Yang L., Pan H., Jiang H., Wei Q., Fang M., Yu H., Zhu C.,
RA Cai Y., He Y., Gan X., Zeng H., Yu D., Zhu Y., Jiang H., Qiu Q., Yang H.,
RA Zhang Y.E., Wang W., Zhu M., He S., Zhang G.;
RT "Tracing the genetic footprints of vertebrate landing in non-teleost ray-
RT finned fishes.";
RL Cell 0:0-0(2021).
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MBN3326034.1}.
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DR EMBL; JAAWVO010078527; MBN3326034.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A8J7P9J3; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000736164; Unassembled WGS sequence.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF18; SUPPRESSOR OF CYTOKINE SIGNALING 9 ISOFORM X1; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000736164};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 308..403
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 398..447
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..46
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..161
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:MBN3326034.1"
FT NON_TER 460
FT /evidence="ECO:0000313|EMBL:MBN3326034.1"
SQ SEQUENCE 460 AA; 51731 MW; 152A3F83A3014770 CRC64;
MSQSPEAEER GKEKERGARP KVRQSRSEER REGNGRKSGR GKKKGRPPQN PLPERPMSDG
FEYGELQGGR DPGDTGLPFQ ERCRWQDLTS AGTALQELGV DRPVAGTEEG EGEGGSAKLP
SSRSLRQKIQ DAVGQCFPIK SSSTPSPSLS PSSSTSSCAS SSSRRKIHLS ELMLDKCPFP
AGSDLAQKWY LIKQHTVPIS QPALLDTLNG NTLGSPITVV EDEDDRLRER RRISIEQGVE
PPPNAQIHTF EQQHFLLQNC LDTLDNVVAS SALSAASSSN LESYRVHTQI DYIHCLVPDL
LQITNLPCYW GVMDRYEAEA LLEGKPEGTF LLRDSAQEDY LFSVSFRRYG RSLHARIEQW
NHNFSFDVHD PSVFYASTVT GLLEHYKDPN SCMFFEPLLS NPIHRVHPFS LQHICRAVIA
SCTTYDGIDV LPIPSALKEH LKEYHYKQKV RVRRLDTWWE
//
