ID A0A8J8W0Q4_9EURO Unreviewed; 962 AA.
AC A0A8J8W0Q4;
DT 25-MAY-2022, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 1.
DT 18-JUN-2025, entry version 17.
DE RecName: Full=Oxysterol binding protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PECM_006677 {ECO:0000313|EMBL:KAF7715617.1};
OS Penicillium ucsense.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=2839758 {ECO:0000313|EMBL:KAF7715617.1, ECO:0000313|Proteomes:UP000631181};
RN [1] {ECO:0000313|EMBL:KAF7715617.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=S1M29 {ECO:0000313|EMBL:KAF7715617.1};
RA Lenz A.R., Galan-Vasquez E., Balbinot E., De Abreu F.P., De Oliveira N.S.,
RA Da Rosa L.O., De Avila E Silva S., Camassola M., Dillon A.J.P.,
RA Perez-Rueda E.;
RT "Gene regulatory networks of Penicillium echinulatum 2HH and Penicillium
RT oxalicum 114-2 inferred by a computational biology approach.";
RL Front. Microbiol. 0:0-0(2020).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|ARBA:ARBA00008842}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF7715617.1}.
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DR EMBL; WIWV01000055; KAF7715617.1; -; Genomic_DNA.
DR OrthoDB; 1854502at2759; -.
DR Proteomes; UP000631181; Unassembled WGS sequence.
DR GO; GO:0032541; C:cortical endoplasmic reticulum; IEA:TreeGrafter.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0097038; C:perinuclear endoplasmic reticulum; IEA:TreeGrafter.
DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR GO; GO:0005319; F:lipid transporter activity; IEA:UniProtKB-ARBA.
DR GO; GO:0032934; F:sterol binding; IEA:TreeGrafter.
DR GO; GO:0006897; P:endocytosis; IEA:TreeGrafter.
DR GO; GO:0035621; P:ER to Golgi ceramide transport; IEA:TreeGrafter.
DR GO; GO:0006887; P:exocytosis; IEA:TreeGrafter.
DR GO; GO:0030011; P:maintenance of cell polarity; IEA:TreeGrafter.
DR GO; GO:0034727; P:piecemeal microautophagy of the nucleus; IEA:TreeGrafter.
DR CDD; cd13289; PH_Osh3p_yeast; 1.
DR FunFam; 2.30.29.30:FF:000369; Oxysterol binding protein; 1.
DR FunFam; 2.40.160.120:FF:000013; Oxysterol binding protein; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.60.120.680; GOLD domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR009038; GOLD_dom.
DR InterPro; IPR036598; GOLD_dom_sf.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041680; PH_8.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972:SF203; OXYSTEROL-BINDING PROTEIN HOMOLOG 3; 1.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF15409; PH_8; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF101576; Supernatant protein factor (SPF), C-terminal domain; 1.
DR PROSITE; PS50866; GOLD; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000631181};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 1..141
FT /note="GOLD"
FT /evidence="ECO:0000259|PROSITE:PS50866"
FT DOMAIN 188..282
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 50..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 341..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 470..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 496..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..350
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..423
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..545
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 962 AA; 105124 MW; 9B139C9FA34B6D19 CRC64;
MAAMEELEIH SKSYFVRWIN VGANQTISWS IQPHKKSVNF GLFKHPGQSS LTSQLPASDS
QSTASNENLP AAGARNQPSP VIEKLTAIGL KQIKWYGKCE ADRISQGTYD VPAAEAGNYA
LVFDNTFSKQ ISKTVTLVLL TYPTGMQPHG SKPSSIARSP AGGSSDSLPQ SRTRGRSKST
LSVQVSDTSV HTGILQKRRR KRHQGWARRY FSLDYTSSTL SYYHDPNSSA LRGAIPLSLA
AVATNEKTRE MSIDSGTEIW HLRASNDADF EAWKGALEKA SSKDTPRPNE LSVASPGAAA
KAGVPPQLRL PSAGYPSPAE EAEWTRVERL VSKVSGSRDA VRRLARDTDP KYMAAPTPSP
APVESRGRGR SPSPNPGAGS GSQDASGLDP KRPFWKRKAS GNSQASPRRP AGPEQTNSSS
SQLVVPKPET NGRPASVHSH TEGVDEIHDH LMAVLSDLDH VVSEFSTLIA ESKQRRAPPR
PTFASRKSME SDISQEFFDA PDGGSHSPFL RIQDSDDEEA SGDRVEDAAE NVEDDAPSDS
EDEADTATLH DTSTASPLFP ARPKSLAPLP LDKVRRRQNI TAPTVLPPSL IGFLRKNVGK
DLSTISMPVS ANEPLSLLQR AAEILEYSTL LDQAAQVSDP VERLMYVTAF AISMLSSNRV
RERSIRKPFN PMLGETYELV REDQGFRFIA EKVSHRPVQL AYQADSREWS LAQSPKPSQK
FWGKSAEITT EGRVRVTLHS TGDRFSWVPA TSFLRNIIAG EKYVEPVGEL AVTNESTGHR
SISTFKSGGM FSGRSEEVTT RAVDSYNSPV SLGLTGTWPA SLSLTRDGSP SGKPIWTAGP
LVPNAPKHYG LTAFAAALNE ITSIEEGHLP VTDSRLRPDQ RALEEGDLDR AEEVKVQLEE
GQRARRREME AAGQTWTPRW FTRVSEDSDG GEVVWRLKGG KEGYWDERAR GTWTDVVPVF
ES
//
