ID A0A8K0VAL7_9RHOB Unreviewed; 677 AA.
AC A0A8K0VAL7;
DT 03-AUG-2022, integrated into UniProtKB/TrEMBL.
DT 03-AUG-2022, sequence version 1.
DT 18-JUN-2025, entry version 15.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00044770};
DE EC=2.4.99.28 {ECO:0000256|ARBA:ARBA00044770};
GN Name=pbpC {ECO:0000313|EMBL:MBL4915732.1};
GN ORFNames=JL811_00740 {ECO:0000313|EMBL:MBL4915732.1};
OS Szabonella alba.
OC Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria;
OC Rhodobacterales; Paracoccaceae; Szabonella.
OX NCBI_TaxID=2804194 {ECO:0000313|EMBL:MBL4915732.1, ECO:0000313|Proteomes:UP000648908};
RN [1] {ECO:0000313|EMBL:MBL4915732.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DMG-N-6 {ECO:0000313|EMBL:MBL4915732.1};
RA Szuroczki S., Abbaszade G., Schumann P., Toth E.;
RT "Tabrizicola alba sp. nov. a motile alkaliphilic bacterium isolated from a
RT soda lake.";
RL Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans,octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.99.28;
CC Evidence={ECO:0000256|ARBA:ARBA00049902};
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004752}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the transpeptidase
CC family. {ECO:0000256|ARBA:ARBA00007090}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the
CC glycosyltransferase 51 family. {ECO:0000256|ARBA:ARBA00007739}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MBL4915732.1}.
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DR EMBL; JAESVN010000001; MBL4915732.1; -; Genomic_DNA.
DR RefSeq; WP_202687143.1; NZ_JAESVN010000001.1.
DR UniPathway; UPA00219; -.
DR Proteomes; UP000648908; Unassembled WGS sequence.
DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:TreeGrafter.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR050396; Glycosyltr_51/Transpeptidase.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR011815; PBP_1c.
DR InterPro; IPR009647; PBP_C.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; TIGR02073; PBP_1c; 1.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF15; PENICILLIN-BINDING PROTEIN 1C; 1.
DR Pfam; PF06832; BiPBP_C; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 3: Inferred from homology;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000648908};
KW Transferase {ECO:0000256|ARBA:ARBA00022676}.
FT DOMAIN 46..219
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 298..508
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT DOMAIN 596..672
FT /note="Penicillin-binding C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06832"
SQ SEQUENCE 677 AA; 71448 MW; 331B2AB8B9282333 CRC64;
MFALALALWA GGGLRDAGDR WVAATVLPPL QVATATEILA RDGQLLRAYQ VADGRWRLAV
SVDRVDPRYL QMLIAFEDRR FRSHAGVDPL AALRAGWQAV TSRRVVSGGS TLTMQVARLL
EESGTGQITG KLRQMRVALA LERRLDKDQI LSLYLHLAPF GGNLEGVRAA TISYFGKEPQ
RLTPAEAALL VALPQSPETR RPDRHADHAE AARARILARA VAAGVIGADQ ALAAQREAVP
TRRRPFPAHA PHLADRVAGP VSSGLSPHRL TIDAGLQKRL EALARDTVAA HGARLQIAMM
IADHRTGEVL ASVGSADYTE EARQGFVDMT RAVRSPGSLL KPLVYALAFD EGLAHPETLI
DDQPMDFAGY RPQNFDRRFR GTLRVREALV ESLNLPVVAL TEAMGPARLM TGLRRAGVDP
RLPGGGGRPG LALALGGVGV TLEEMAGLYA ALAHGGVARP LRVSAGDAGA GTRVISAVAA
WQIGDILAGM PPPGGGGRGI AYKTGTSYGH RDAWALGYDG RHVVGVWLGR ADGTPVPGVF
GADLAAPVLA QAFARIGRRI EPLPPPPSTA LILSNAALPQ PLQRFRPRGA AFGPDPGAPA
VAFPPDGAQV ELLPEGVLLR VRGGTAPFTW LADGVPVVTA LRSRDALVPL TGPGFVTLSV
IDANGRSARS SVRLAMP
//
