ID A0A8M9Q6Q0_DANRE Unreviewed; 1203 AA.
AC A0A8M9Q6Q0;
DT 03-AUG-2022, integrated into UniProtKB/TrEMBL.
DT 28-JAN-2026, sequence version 2.
DT 28-JAN-2026, entry version 19.
DE SubName: Full=Uncharacterized protein col18a1b isoform X2 {ECO:0000313|RefSeq:XP_021332754.2};
GN Name=col18a1b {ECO:0000313|RefSeq:XP_021332754.2};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Proteomes:UP000000437, ECO:0000313|RefSeq:XP_021332754.2};
RN [1] {ECO:0000313|RefSeq:XP_021332754.2}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_021332754.2};
RC TISSUE=Fibroblasts and whole tissue
RC {ECO:0000313|RefSeq:XP_021332754.2};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the multiplexin collagen family.
CC {ECO:0000256|ARBA:ARBA00061275}.
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DR RefSeq; XP_021332754.2; XM_021477079.3.
DR AlphaFoldDB; A0A8M9Q6Q0; -.
DR KEGG; dre:100334893; -.
DR CTD; 100334893; -.
DR Proteomes; UP000000437; Chromosome 6.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00247; Endostatin-like; 1.
DR FunFam; 3.10.100.10:FF:000008; collagen alpha-1(XVIII) chain isoform X1; 1.
DR FunFam; 3.40.1620.70:FF:000003; Collagen type XVIII alpha 1; 1.
DR FunFam; 2.60.120.200:FF:000039; Collagen XV alpha 1 chain; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 3.40.1620.70; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR050149; Collagen_superfamily.
DR InterPro; IPR010515; Collagenase_NC10/endostatin.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR045463; XV/XVIII_trimerization_dom.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24023:SF1118; LAMININ G DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01391; Collagen; 2.
DR Pfam; PF20010; Collagen_trimer; 1.
DR Pfam; PF06482; Endostatin; 1.
DR SMART; SM00210; TSPN; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydroxylation {ECO:0000256|ARBA:ARBA00023278};
KW Proteoglycan {ECO:0000256|ARBA:ARBA00022974};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
SQ SEQUENCE 1203 AA; 127552 MW; 3A407A2C76D09886 CRC64;
MLLFHTHLDL TLKKQMHVIK MLSFWFILAF SLNLVLTDAS EAEERGVSLL QLIGNLPPEN
ITRGQGPNGK AYYLFTNNTN MEQLALTHLP SPLYRDFSLV FHLKPTSEDA GVIFSITDSN
QNIMYVGVKL SAVKDGNRKV IFYYTEPDAE KSQEVASFEV AHRPEEWSRF SLAINLDQVF
FYEDCDSEPK VATLQRSPDY LELETNSKIF VGQSGVDDPN KFQGMISELR MVGKPQVAEH
HCDDSDDDDY EDSGDNGSGI EDRMNIQYNL PLPPQVVPNK LDIGAQQSAT GFSGAKGVSK
GVGEEKWKLT GPKHDWATSS STDGTRGEKG DRGEKGMKGE KGVGHPGPQG LPGPPGPPGP
SISDRTTFVD MEGSGSSQGL CCPGPPGPPG PPGPPGPEWE NGSEFDPTEI SPTGLPGQSV
FRGRPGPPGR PGKPGPPGPP GQKGDCWKLD SPGVSGERQS SSSWFFTNWF PSWETSEAQG
TEGSSGMPGQ EGLVGLPGPM GPQGHPGPPG LPGPAIQISR NGNKTEIDLR YIPGAVGLPG
PQGPQGIPGL PGKPGLPGIP GQKGDEGQRG REGMPGLDGF PGQIGLKGER GWKGDRGEPG
RKTGPPGPPG PPGPPGEVTY VNGSMTPGLP GQAGFPGPVG QKGDQGERGL PGVSIKGQKG
EPGLIYDSTR SPIYMGGPTG QLGELGPPGP MGPAGPAGPQ GPKGEIGIPG RPGRPGLIGK
KGQKGDSGGA EGYAYQGPPG PPGPPGPPGL PGRFHGYDDV SSRFPHAIKG DKGERGAPGI
PGLPGLTTTY DIYSFKHEMK GEPGFKGEKG EPGGGYYEPH YGGVQGPPGR PGPPGPRGES
IRGPPGPPGP PGAPGTGYEG RPGSPGPPGP PGLPGSLLPS ADGPSQTISV PGPPGPPGPP
GRPGQPVHLS GVTVMRSVDT MAATTIQYPE GTLIYVKDNK ELYLRVHEGV REVLLGEYTA
FPKGLDKMEV VAPPQVVFYP SDYPTVAPPR APYPQPYPMP YDRRFGYTPS HRPVIQETRL
PAHVHTSGRA LHLVALNSPQ RGNMQGIRGV DHQCFLQARA IGLKGTFRAF LSSQLQDLNS
IVRKNDKDQL PIVNLKDEEL FSNWESIFED SEGKMYDDAR IYSFDGRDVL NDDAWPEKMV
WHGSSTHGQR HTESFCETWR VGSDGVMGMA SSLQEGYLLQ QLPRRCTSSY IVLCIENSYI
AEP
//
