ID A0A8P4GNT5_DICLA Unreviewed; 564 AA.
AC A0A8P4GNT5;
DT 12-OCT-2022, integrated into UniProtKB/TrEMBL.
DT 12-OCT-2022, sequence version 1.
DT 28-JAN-2026, entry version 18.
DE SubName: Full=Suppressor of cytokine signaling 5b {ECO:0000313|Ensembl:ENSDLAP00005078653.1};
GN Name=socs5b {ECO:0000313|Ensembl:ENSDLAP00005078653.1};
OS Dicentrarchus labrax (European seabass) (Morone labrax).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Moronidae; Dicentrarchus.
OX NCBI_TaxID=13489 {ECO:0000313|Ensembl:ENSDLAP00005078653.1, ECO:0000313|Proteomes:UP000694389};
RN [1] {ECO:0000313|Ensembl:ENSDLAP00005078653.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDLAP00005078653.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_051283851.1; XM_051427891.1.
DR AlphaFoldDB; A0A8P4GNT5; -.
DR Ensembl; ENSDLAT00005083981.1; ENSDLAP00005078653.1; ENSDLAG00005032498.1.
DR GeneID; 127378711; -.
DR CTD; 559639; -.
DR GeneTree; ENSGT00940000164285; -.
DR OMA; CQNLFNH; -.
DR OrthoDB; 8820570at2759; -.
DR Proteomes; UP000694389; Unassembled WGS sequence.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000694389};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 408..503
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 498..547
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 45..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 97..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 277..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..58
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..330
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 564 AA; 62087 MW; 72BD67DE3B86F328 CRC64;
MKKVGNMWSN LKSKCQTLFH NNSSGPSESR VEADAVHCVL DLGQGGSSGE AQASGASSPS
RSLLPVPMVT TGRRHHHNCV SDIPQIVEIT IDKDTEDVRG GSGGVPLARR DSYSRHAPWG
GKKKHSCSTK TQSSLEADRR SGRIRGSGNR RDRRYGVGSI QEMSDSVSGG RSLNARSLRQ
RLSDTVGLCL PLPARRCSRS SKNPVTSKRK IHLTELMLET CPFPPGSDLA HKWHLIKQHT
APVSPHSSTA LLDAFDPAHP SPEDEEERLR ERRRLSIEEG VDPPPNAQIH TLEASVPGSS
LYKLGPKMAP GMGEASGEGR ASGAGSSVGA GSSGACGQVL AAAASAQDCD SEEDSTTLCL
QARRPKQRHA SGDGHLSRQQ PGPWKVHTQI DYIHCLVPDL LQITALPCYW GVMDRYEAEA
LLDGRPEGTF LLRDSAQEDY LFSVSFRRYN RSLHARIEQW NHNFSFDAHD PCVFHSSTVT
GLLEHYKDPS ACMFFEPLLT APLHRTFPFG LQHLARAAIC RWTTYDGIGS LPLPPALQDF
LKEYHYKQKV RVRWLEREPP LKVK
//
