ID A0A8P4KGG4_DICLA Unreviewed; 569 AA.
AC A0A8P4KGG4;
DT 12-OCT-2022, integrated into UniProtKB/TrEMBL.
DT 12-OCT-2022, sequence version 1.
DT 28-JAN-2026, entry version 18.
DE RecName: Full=Suppressor of cytokine signaling 9 {ECO:0008006|Google:ProtNLM};
GN Name=socs9 {ECO:0000313|Ensembl:ENSDLAP00005073186.1};
OS Dicentrarchus labrax (European seabass) (Morone labrax).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Moronidae; Dicentrarchus.
OX NCBI_TaxID=13489 {ECO:0000313|Ensembl:ENSDLAP00005073186.1, ECO:0000313|Proteomes:UP000694389};
RN [1] {ECO:0000313|Ensembl:ENSDLAP00005073186.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDLAP00005073186.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_051254272.1; XM_051398312.1.
DR RefSeq; XP_051254273.1; XM_051398313.1.
DR AlphaFoldDB; A0A8P4KGG4; -.
DR Ensembl; ENSDLAT00005071132.1; ENSDLAP00005073186.1; ENSDLAG00005027951.1.
DR GeneID; 127362530; -.
DR CTD; 100003691; -.
DR GeneTree; ENSGT00940000164285; -.
DR OMA; SYRIHTQ; -.
DR OrthoDB; 8820570at2759; -.
DR Proteomes; UP000694389; Unassembled WGS sequence.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF18; SUPPRESSOR OF CYTOKINE SIGNALING 9 ISOFORM X1; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000694389};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 417..512
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 507..556
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 111..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..47
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 569 AA; 62872 MW; 672E4F7271B1B419 CRC64;
MSLPKESGNR GKDRERGARP KVRQSRSEER RDAGSGRKGG KGKKRGLASH EPAAERPVSD
GFEYGELLSD LETKDQSSSS PLKESWRWQG LEAAASLLGQ ERVTARPGLG TVSSATELSA
PSDGEGRGSS SSRTFRQKIQ DAVGQCFPIK THTAAAPAPT PQALSSSTAC ASSRRKIHLS
ELMLDDCPFP VGSELAQKWY LIKQHTAPIT QPPVLDSAVV CSAPTSAIAT VVEDVDDRLR
ERRRISIEQG VEPPPNAEIH TFEVTAQINP LYKHGPKLAH GMNELAGADR ASVHQQQQLL
LQRQQQHQLL LQRCLDTLDE VVASASASAS ASASASASAS VPVPVPVPVP VPVPVHTCDT
ISDSLVDPEV AATSVPSRAV LPQTEHHKSH DGYRIHTQID YIHCLVPDLL QITNLPCYWG
VMDRYEAETL LEGKPEGTFL LRDSAQEDYL FSVSFRRYGR SLHARIEQWN HNFSFDVHDP
SVFHAPTVTG LLEHYKDPNS CMFFEPLLSN PIHRTQPFTL QHICRAAISS CTTYDGINML
PIPTALKKHL KEYHYKQKVR VRRMDTWWE
//
