ID A0A8R2DQ42_BOMMO Unreviewed; 1186 AA.
AC A0A8R2DQ42;
DT 12-OCT-2022, integrated into UniProtKB/TrEMBL.
DT 12-OCT-2022, sequence version 1.
DT 28-JAN-2026, entry version 12.
DE RecName: Full=Thrombospondin-like N-terminal domain-containing protein {ECO:0000259|SMART:SM00210};
OS Bombyx mori (Silk moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC Bombycidae; Bombycinae; Bombyx.
OX NCBI_TaxID=7091 {ECO:0000313|EnsemblMetazoa:XP_021208106.2, ECO:0000313|Proteomes:UP000005204};
RN [1] {ECO:0000313|Proteomes:UP000005204}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=p50T {ECO:0000313|Proteomes:UP000005204};
RX PubMed=19121390; DOI=10.1016/j.ibmb.2008.11.004;
RG International Silkworm Genome Consortium;
RT "The genome of a lepidopteran model insect, the silkworm Bombyx mori.";
RL Insect Biochem. Mol. Biol. 38:1036-1045(2008).
RN [2] {ECO:0000313|EnsemblMetazoa:XP_021208106.2}
RP IDENTIFICATION.
RC STRAIN=p50T (Dazao) {ECO:0000313|EnsemblMetazoa:XP_021208106.2};
RG EnsemblMetazoa;
RL Submitted (JUN-2022) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR AlphaFoldDB; A0A8R2DQ42; -.
DR EnsemblMetazoa; XM_021352431.2; XP_021208106.2; LOC101737883.
DR Proteomes; UP000005204; Unassembled WGS sequence.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 3.40.1620.70; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR050938; Collagen_Structural_Proteins.
DR InterPro; IPR010515; Collagenase_NC10/endostatin.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR045463; XV/XVIII_trimerization_dom.
DR PANTHER; PTHR37456:SF6; COLLAGEN ALPHA-1(XXIII) CHAIN-LIKE ISOFORM X2; 1.
DR PANTHER; PTHR37456; SI:CH211-266K2.1; 1.
DR Pfam; PF01391; Collagen; 4.
DR Pfam; PF20010; Collagen_trimer; 1.
DR Pfam; PF06482; Endostatin; 1.
DR SMART; SM00210; TSPN; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Reference proteome {ECO:0000313|Proteomes:UP000005204};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1186
FT /note="Thrombospondin-like N-terminal domain-containing
FT protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035825471"
FT DOMAIN 41..232
FT /note="Thrombospondin-like N-terminal"
FT /evidence="ECO:0000259|SMART:SM00210"
FT REGION 266..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 855..882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..303
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..327
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..337
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 406..421
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..450
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..567
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..609
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..629
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 792..804
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 855..864
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 868..880
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1186 AA; 123986 MW; 863C178DB932733B CRC64;
MESFRYISLP LLLLVTACLA TDGLFGSSMY QNGEPFIDIP EYDLLHAIGV PFSNPKTQYF
DEGLDGFPAY GLMPGSDIKS PYRLFMPEKL YSEFSITATV RPANKDGGFL FSVVNPLETV
VQLGVQLIPS GPGLMNISLL YTDANIYAFS QTIASFVVPT FAKKWSRFAL KVSLENVTLY
LNCHEFDTVV VRRNPLELVF DSASTLYVGQ AGPLIRGAFH GAFQELKLYG SPSQAEVQCV
NTFEEIDKSG EGDEIDIDNF LVDQEEDSEG SGRYGTIPPF PPPPPGLDGY SLRLRGDKGE
RGPRGPPGES IRGPPGPPGP PGPPGPPGTA TESSGSGDDQ IFGENYASLG QCGCNASTIM
SLLQTAPELR GSPGPPGMIG ADGRAGPPGM PGQPGTPGER GPVGPRGDKG DRGDAGTRGH
EGQPGPKGEA GVDGRPGTAG PPGPPGPPGT PDYNNFESNW KPRQIYKESL MGAYGSAIGR
PGAPGPKGDS GQPGPMGPQG ERGFPGQKGE RGQNGAVGAK GDRGHPGPQG DRGVKGDRGN
PGFDGRPGIP GANGRPADKG EKGERGEPGP PGSPPAGVFN AADPEFMVAG SQVTGAKGDK
GEKGEKGTRG NDGPPGFPGK DGKQGERGDI GPSGLPGMAG SPGPQGFKGD RGERGPPGPI
SVASAGTDII TIKGDKGEPG ARGRRGRSGP GGARGATGAP GPPGPAGRPG DKGDTGLPGW
MNSKGRPGTL GPPGAPGPVG PKGEKGDPGV NILDVSMFKG EKGDRGFDGV PGVQGPPGPP
GKPASEPVQY LPGPPGPPGP PGSPGTPGVS VVGPKGEPGV SYYEEGPVHG SPKFYGRPVL
KSPLDELKAL KELKDLKDKE RDRGGFSARS QPADESSAQK TVPGAAVFQT TEEMMKLASS
SPVGALAYVA EEQALFVKVN SGWQYVLLGS LVTQSKPPPT PAPAPLPMPA ASLVHVPPIS
NLVENSPTPI GPSLRMAALN DPLSGNMHGV RRADYACYRQ ARRAGLRGTF RAFLTSRIQN
LDSTVRYADR HLPVLNTQGD VLFKSFSDIF DGSGGIVAGT PRIYSFNGKN IITDSHWPQK
LIWHGSHASG ERALDTFCEE WQSNDPTNKG MAASLYSHKI LSQERYSCNN HFAVLCIEAT
SNVSVRRKRD THRFNTTEDS DEDYEMRPDE YEELINDIIA QPLRYN
//
