ID A0A8R2HPJ5_BOMMO Unreviewed; 1174 AA.
AC A0A8R2HPJ5;
DT 12-OCT-2022, integrated into UniProtKB/TrEMBL.
DT 12-OCT-2022, sequence version 1.
DT 28-JAN-2026, entry version 12.
DE RecName: Full=Thrombospondin-like N-terminal domain-containing protein {ECO:0000259|SMART:SM00210};
OS Bombyx mori (Silk moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC Bombycidae; Bombycinae; Bombyx.
OX NCBI_TaxID=7091 {ECO:0000313|EnsemblMetazoa:XP_021208109.2, ECO:0000313|Proteomes:UP000005204};
RN [1] {ECO:0000313|Proteomes:UP000005204}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=p50T {ECO:0000313|Proteomes:UP000005204};
RX PubMed=19121390; DOI=10.1016/j.ibmb.2008.11.004;
RG International Silkworm Genome Consortium;
RT "The genome of a lepidopteran model insect, the silkworm Bombyx mori.";
RL Insect Biochem. Mol. Biol. 38:1036-1045(2008).
RN [2] {ECO:0000313|EnsemblMetazoa:XP_021208109.2}
RP IDENTIFICATION.
RC STRAIN=p50T (Dazao) {ECO:0000313|EnsemblMetazoa:XP_021208109.2};
RG EnsemblMetazoa;
RL Submitted (JUN-2022) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR AlphaFoldDB; A0A8R2HPJ5; -.
DR SMR; A0A8R2HPJ5; -.
DR EnsemblMetazoa; XM_021352434.2; XP_021208109.2; LOC101737883.
DR Proteomes; UP000005204; Unassembled WGS sequence.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 3.40.1620.70; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR050938; Collagen_Structural_Proteins.
DR InterPro; IPR010515; Collagenase_NC10/endostatin.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR045463; XV/XVIII_trimerization_dom.
DR PANTHER; PTHR37456:SF6; COLLAGEN ALPHA-1(XXIII) CHAIN-LIKE ISOFORM X2; 1.
DR PANTHER; PTHR37456; SI:CH211-266K2.1; 1.
DR Pfam; PF01391; Collagen; 3.
DR Pfam; PF20010; Collagen_trimer; 1.
DR Pfam; PF06482; Endostatin; 1.
DR SMART; SM00210; TSPN; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Reference proteome {ECO:0000313|Proteomes:UP000005204};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1174
FT /note="Thrombospondin-like N-terminal domain-containing
FT protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035901257"
FT DOMAIN 41..232
FT /note="Thrombospondin-like N-terminal"
FT /evidence="ECO:0000259|SMART:SM00210"
FT REGION 245..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 843..870
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..310
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..409
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..438
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..555
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..597
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 608..617
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 780..792
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 843..852
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 856..868
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1174 AA; 122653 MW; 207E3D6D464D0D75 CRC64;
MESFRYISLP LLLLVTACLA TDGLFGSSMY QNGEPFIDIP EYDLLHAIGV PFSNPKTQYF
DEGLDGFPAY GLMPGSDIKS PYRLFMPEKL YSEFSITATV RPANKDGGFL FSVVNPLETV
VQLGVQLIPS GPGLMNISLL YTDANIYAFS QTIASFVVPT FAKKWSRFAL KVSLENVTLY
LNCHEFDTVV VRRNPLELVF DSASTLYVGQ AGPLIRGAFH GAFQELKLYG SPSQAEVQCV
NTFEVDQEED SEGSGRYGTI PPFPPPPPGL DGYSLRLRGD KGERGPRGPP GESIRGPPGP
PGPPGPPGPP GTATESSGSG DDRSSVKQIF GENYASLGQC GCNASTIMSL LQTAPELRGS
PGPPGMIGAD GRAGPPGMPG QPGTPGERGP VGPRGDKGDR GDAGTRGHEG QPGPKGEAGV
DGRPGTAGPP GPPGPPGTPD YNNFESNWKP RQIYKESLMG AYGSAIGRPG APGPKGDSGQ
PGPMGPQGER GFPGQKGERG QNGAVGAKGD RGHPGPQGDR GVKGDRGNPG FDGRPGIPGA
NGRPADKGEK GERGEPGPPG SPPAGVFNAA DPEFMVAGSQ VTGAKGDKGE KGEKGTRGND
GPPGFPGKDG KQGERGDIGP SGLPGMAGSP GPQGFKGDRG ERGPPGPISV ASAGTDIITI
KGDKGEPGAR GRRGRSGPGG ARGATGAPGP PGPAGRPGDK GDTGLPGWMN SKGRPGTLGP
PGAPGPVGPK GEKGDPGVNI LDVSMFKGEK GDRGFDGVPG VQGPPGPPGK PASEPVQYLP
GPPGPPGPPG SPGTPGVSVV GPKGEPGVSY YEEGPVHGSP KFYGRPVLKS PLDELKALKE
LKDLKDKERD RGGFSARSQP ADESSAQKTV PGAAVFQTTE EMMKLASSSP VGALAYVAEE
QALFVKVNSG WQYVLLGSLV TQSKPPPTPA PAPLPMPAAS LVHVPPISNL VENSPTPIGP
SLRMAALNDP LSGNMHGVRR ADYACYRQAR RAGLRGTFRA FLTSRIQNLD STVRYADRHL
PVLNTQGDVL FKSFSDIFDG SGGIVAGTPR IYSFNGKNII TDSHWPQKLI WHGSHASGER
ALDTFCEEWQ SNDPTNKGMA ASLYSHKILS QERYSCNNHF AVLCIEATSN VSVRRKRDTH
RFNTTEDSDE DYEMRPDEYE ELINDIIAQP LRYN
//
