ID A0A8R2NNF6_ACYPI Unreviewed; 1033 AA.
AC A0A8R2NNF6;
DT 12-OCT-2022, integrated into UniProtKB/TrEMBL.
DT 12-OCT-2022, sequence version 1.
DT 28-JAN-2026, entry version 14.
DE RecName: Full=Thrombospondin-like N-terminal domain-containing protein {ECO:0000259|SMART:SM00210};
OS Acyrthosiphon pisum (Pea aphid).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Hemiptera; Sternorrhyncha; Aphidomorpha;
OC Aphidoidea; Aphididae; Macrosiphini; Acyrthosiphon.
OX NCBI_TaxID=7029 {ECO:0000313|EnsemblMetazoa:XP_029344257.1, ECO:0000313|Proteomes:UP000007819};
RN [1] {ECO:0000313|Proteomes:UP000007819}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LSR1 {ECO:0000313|Proteomes:UP000007819};
RA Jiang H., Abraham K., Ali S., Alsbrooks S.L., Anim B.N., Anosike U.S.,
RA Attaway T., Bandaranaike D.P., Battles P.K., Bell S.N., Bell A.V.,
RA Beltran B., Bickham C., Bustamante Y., Caleb T., Canada A., Cardenas V.,
RA Carter K., Chacko J., Chandrabose M.N., Chavez D., Chavez A., Chen L.,
RA Chu H.-S., Claassen K.J., Cockrell R., Collins M., Cooper J.A., Cree A.,
RA Curry S.M., Da Y., Dao M.D., Das B., Davila M.-L., Davy-Carroll L.,
RA Denson S., Dinh H., Ebong V.E., Edwards J.R., Egan A., El-Daye J.,
RA Escobedo L., Fernandez S., Fernando P.R., Flagg N., Forbes L.D.,
RA Fowler R.G., Fu Q., Gabisi R.A., Ganer J., Garbino Pronczuk A.,
RA Garcia R.M., Garner T., Garrett T.E., Gonzalez D.A., Hamid H.,
RA Hawkins E.S., Hirani K., Hogues M.E., Hollins B., Hsiao C.-H., Jabil R.,
RA James M.L., Jhangiani S.N., Johnson B., Johnson Q., Joshi V., Kalu J.B.,
RA Kam C., Kashfia A., Keebler J., Kisamo H., Kovar C.L., Lago L.A.,
RA Lai C.-Y., Laidlaw J., Lara F., Le T.-K., Lee S.L., Legall F.H.,
RA Lemon S.J., Lewis L.R., Li B., Liu Y., Liu Y.-S., Lopez J., Lozado R.J.,
RA Lu J., Madu R.C., Maheshwari M., Maheshwari R., Malloy K., Martinez E.,
RA Mathew T., Mercado I.C., Mercado C., Meyer B., Montgomery K., Morgan M.B.,
RA Munidasa M., Nazareth L.V., Nelson J., Ng B.M., Nguyen N.B., Nguyen P.Q.,
RA Nguyen T., Obregon M., Okwuonu G.O., Onwere C.G., Orozco G., Parra A.,
RA Patel S., Patil S., Perez A., Perez Y., Pham C., Primus E.L., Pu L.-L.,
RA Puazo M., Qin X., Quiroz J.B., Reese J., Richards S., Rives C.M.,
RA Robberts R., Ruiz S.J., Ruiz M.J., Santibanez J., Schneider B.W.,
RA Sisson I., Smith M., Sodergren E., Song X.-Z., Song B.B., Summersgill H.,
RA Thelus R., Thornton R.D., Trejos Z.Y., Usmani K., Vattathil S.,
RA Villasana D., Walker D.L., Wang S., Wang K., White C.S., Williams A.C.,
RA Williamson J., Wilson K., Woghiren I.O., Woodworth J.R., Worley K.C.,
RA Wright R.A., Wu W., Young L., Zhang L., Zhang J., Zhu Y., Muzny D.M.,
RA Weinstock G., Gibbs R.A.;
RL Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:XP_029344257.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2022) to UniProtKB.
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DR RefSeq; XP_029344257.1; XM_029488397.1.
DR AlphaFoldDB; A0A8R2NNF6; -.
DR EnsemblMetazoa; XM_029488397.1; XP_029344257.1; LOC100573836.
DR GeneID; 100573836; -.
DR OrthoDB; 5983381at2759; -.
DR Proteomes; UP000007819; Chromosome A1.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0031012; C:extracellular matrix; IEA:TreeGrafter.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0030020; F:extracellular matrix structural constituent conferring tensile strength; IEA:TreeGrafter.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:TreeGrafter.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 3.40.1620.70; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR050149; Collagen_superfamily.
DR InterPro; IPR010515; Collagenase_NC10/endostatin.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR045463; XV/XVIII_trimerization_dom.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24023:SF914; OTOLIN-1; 1.
DR Pfam; PF01391; Collagen; 2.
DR Pfam; PF20010; Collagen_trimer; 1.
DR Pfam; PF06482; Endostatin; 1.
DR SMART; SM00210; TSPN; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
PE 4: Predicted;
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Reference proteome {ECO:0000313|Proteomes:UP000007819};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1033
FT /note="Thrombospondin-like N-terminal domain-containing
FT protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035837468"
FT DOMAIN 31..222
FT /note="Thrombospondin-like N-terminal"
FT /evidence="ECO:0000259|SMART:SM00210"
FT REGION 234..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 942..965
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1001..1033
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..245
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..265
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..289
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..302
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..389
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..568
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 657..676
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..698
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1022..1033
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1033 AA; 108111 MW; E0EAFD4EC8350A3F CRC64;
MSWTSIVVCA TLCGFGAATD EFSGGKFLPD EHDLQTAIKV PFEDPQLYFD SGEDGFPAFG
IKPGSDIKSP YRLFLPEKLY SEFSIVVNFK LNSMDGGFLF AVVNPLENVV QLGVQVVPSS
SSAMNVSFLY TDVNKYSSSS NVLATFSVPW KIRKYIRLSL KVTREYVRLF GRCLEPQTVM
VVRDPVELLF DSASTLYIGQ AGPLIKGPFD GAIQEMKIYA SPDFADIQCT ELLQPDDDKE
PENPEDLANG GYSDRPPAPP PPPPSNENHS YQTPNIKGDK GDAGQKGESI RGPPGPPGPP
GSPFSGDFAT DEELVKSGVS GPRGPPGICS CNLTTLFAPG NIPELIQGPP GNPGIDGKMG
LTGLPGAVGL PGDRGLEGIK GDKGDRGDVG PRGNEGIQGP KGDSGIDGER GLQGPPGPPG
PPGGSDFSNN DDIGFESNVG RPGPPGPKGD PGVDGAPGLK GAKGIQGNKG VRGELGSKGV
KGDKGHAGSP GPQGFKGERG IRGFDGTPGM PGENSRPAPK GEKGDSGTPG PPGPPGPAQS
GVKIDKTDTA VVKTVKGDKG TKGDHGEKGS VGNLGPGGNP GPPGLTGPKG ERGEPGLPAP
SLSTTDLGMS IKGDKGEMGR RGRRGKPGPI GPPGPPGEIG LPGLRDDGSP GKPGGLKGDK
GDPGVSVKGD KGDPGKDGIP GAGGTYVPVP GPPGPPGIPG VAIEGQKGEP GDPGFSSSPL
RSEINEPVIV PGAMTFPNKK SMINVTDRTQ MGTIAFIIEE EALLVRVTRG WQYISLGSLV
TTGIDPVPTS VPIPTRVPLE SSNLVHNHPV KDNTMWHPKM LRIAALNEPY TGNMHGVQSV
DYSCYRQSQR AGLHGAFKAF LSSRINNLKT IVHESDRDLP VVNIKGDVLF NSWKDIFSEN
GAFISQQPRI YSFSGKNVLT DFTWPQKTIW HGSDMSGDSA VDGNCDAWNS ESSDKRGLGS
SLTPKSDRQA KLLDQDSAFD CRNFFVVLCV EITPHSGAMF SRKRRSGGGG FHDEPQPPMS
RQEYEKLMED IGA
//
