ID A0A8R7QGG2_TRIUA Unreviewed; 618 AA.
AC A0A8R7QGG2;
DT 12-OCT-2022, integrated into UniProtKB/TrEMBL.
DT 12-OCT-2022, sequence version 1.
DT 28-JAN-2026, entry version 13.
DE RecName: Full=YTH domain-containing family protein {ECO:0000256|RuleBase:RU369095};
GN Name=LOC125510874
GN {ECO:0000313|EnsemblPlants:TuG1812G0500004496.01.T01};
OS Triticum urartu (Red wild einkorn) (Crithodium urartu).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4572 {ECO:0000313|EnsemblPlants:TuG1812G0500004496.01.T01, ECO:0000313|Proteomes:UP000015106};
RN [1] {ECO:0000313|Proteomes:UP000015106}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=cv. G1812 {ECO:0000313|Proteomes:UP000015106};
RX PubMed=23535596; DOI=10.1038/nature11997;
RA Ling H.Q., Zhao S., Liu D., Wang J., Sun H., Zhang C., Fan H., Li D.,
RA Dong L., Tao Y., Gao C., Wu H., Li Y., Cui Y., Guo X., Zheng S., Wang B.,
RA Yu K., Liang Q., Yang W., Lou X., Chen J., Feng M., Jian J., Zhang X.,
RA Luo G., Jiang Y., Liu J., Wang Z., Sha Y., Zhang B., Wu H., Tang D.,
RA Shen Q., Xue P., Zou S., Wang X., Liu X., Wang F., Yang Y., An X., Dong Z.,
RA Zhang K., Zhang X., Luo M.C., Dvorak J., Tong Y., Wang J., Yang H., Li Z.,
RA Wang D., Zhang A., Wang J.;
RT "Draft genome of the wheat A-genome progenitor Triticum urartu.";
RL Nature 496:87-90(2013).
RN [2] {ECO:0000313|EnsemblPlants:TuG1812G0500004496.01.T01}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. G1812
RC {ECO:0000313|EnsemblPlants:TuG1812G0500004496.01.T01};
RA Ling H., Ma B., Shi X., Liu H., Dong L., Sun H., Cao Y., Gao Q., Zheng S.,
RA Li Y., Yu Y., Du H., Qi M., Li Y., Yu H., Cui Y., Wang N., Chen C., Wu H.,
RA Zhao Y., Zhang J., Li Y., Zhou W., Zhang B., Hu W., Eijk M., Tang J.,
RA Witsenboer H., Zhao S., Li Z., Zhang A., Wang D., Liang C.;
RT "The Triticum urartu genome reveals the dynamic nature of wheat genome
RT evolution.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:TuG1812G0500004496.01.T01}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (JUN-2022) to UniProtKB.
CC -!- FUNCTION: Specifically recognizes and binds N6-methyladenosine (m6A)-
CC containing RNAs, and regulates mRNA stability. M6A is a modification
CC present at internal sites of mRNAs and some non-coding RNAs and plays a
CC role in mRNA stability and processing. {ECO:0000256|RuleBase:RU369095}.
CC -!- SIMILARITY: Belongs to the YTHDF family.
CC {ECO:0000256|RuleBase:RU369095}.
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DR RefSeq; XP_048532104.1; XM_048676147.1.
DR AlphaFoldDB; A0A8R7QGG2; -.
DR EnsemblPlants; TuG1812G0500004496.01.T01; TuG1812G0500004496.01.T01; TuG1812G0500004496.01.
DR GeneID; 125510874; -.
DR Gramene; TuG1812G0500004496.01.T01; TuG1812G0500004496.01.T01; TuG1812G0500004496.01.
DR KEGG; tua:125510874; -.
DR OrthoDB; 306690at2759; -.
DR Proteomes; UP000015106; Chromosome 5.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0003729; F:mRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:1990247; F:N6-methyladenosine-containing RNA reader activity; IEA:UniProtKB-UniRule.
DR GO; GO:0061157; P:mRNA destabilization; IEA:TreeGrafter.
DR CDD; cd21134; YTH; 1.
DR Gene3D; 3.10.590.10; ph1033 like domains; 1.
DR InterPro; IPR007275; YTH_domain.
DR InterPro; IPR045168; YTH_prot.
DR PANTHER; PTHR12357:SF67; YTH DOMAIN-CONTAINING FAMILY PROTEIN; 1.
DR PANTHER; PTHR12357; YTH YT521-B HOMOLOGY DOMAIN-CONTAINING; 1.
DR Pfam; PF04146; YTH; 1.
DR PROSITE; PS50882; YTH; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000015106};
KW RNA-binding {ECO:0000256|RuleBase:RU369095}.
FT DOMAIN 381..516
FT /note="YTH"
FT /evidence="ECO:0000259|PROSITE:PS50882"
FT REGION 125..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..136
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..207
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..224
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..575
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..588
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 618 AA; 67222 MW; C7C1348BADA32E0C CRC64;
MAAAAAAAAD QATNLLQKLS LDAKTEAIDA PAAKEKASGG LGGKLNGVAA TRNPRASEQW
ANPQDYSDAS MYYGAYPAAY YCAGWGDYSM YLNQDGVETP TAGAYGDMYC YPQYGHDGQM
YGSQQYQYPS SYHQPQNTAS KPQYKSKTDK LAPSKDISST VADPLHAVAS APKATANSVD
EVKGLKKTST PLNPSGNNGS YLNQSSRPAY PWYGGQIYQG KQQKPSSGNP TSTDSNPKSK
VQSKNQNTQP LPPLMSLPNS PVASMYAANG MYNSNAYGGF WYGSQFYGPG MYGGWNNLSD
GKYKPRGRTA YGSYGFPNEN LDGLNELKRG PRSGLYNNQQ GFGPAAVTAV KAQDVSATDG
SNAVVQDQYN GSDLADTYEN AKFFIIKSYS EDDVHKSIKY NVWASTPNGN KKLDSAYLEA
KSVNSPVFLL FSVNTSGQFV GLAEMVGQVD FDKTVEHWQQ DKWTGCFPVK WHIVKDIPNN
LLKHIILEYN ENKPVTNSRD TQEVKLEQGL QVLKIFKDHV SKTSILDDFS FYDNREKIMQ
ERKSQRQQQL KKITSPKLLP TVDNTENDSG NAQESQKPEV TGENKSVVED NVEAAAVSGV
APKDANPTAA SLAVANGC
//
