ID A0A8R7RC45_TRIUA Unreviewed; 1149 AA.
AC A0A8R7RC45;
DT 12-OCT-2022, integrated into UniProtKB/TrEMBL.
DT 12-OCT-2022, sequence version 1.
DT 28-JAN-2026, entry version 17.
DE RecName: Full=Disease resistance protein RGA3 {ECO:0008006|Google:ProtNLM};
OS Triticum urartu (Red wild einkorn) (Crithodium urartu).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4572 {ECO:0000313|EnsemblPlants:TuG1812S0002807600.01.T01, ECO:0000313|Proteomes:UP000015106};
RN [1] {ECO:0000313|Proteomes:UP000015106}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=cv. G1812 {ECO:0000313|Proteomes:UP000015106};
RX PubMed=23535596; DOI=10.1038/nature11997;
RA Ling H.Q., Zhao S., Liu D., Wang J., Sun H., Zhang C., Fan H., Li D.,
RA Dong L., Tao Y., Gao C., Wu H., Li Y., Cui Y., Guo X., Zheng S., Wang B.,
RA Yu K., Liang Q., Yang W., Lou X., Chen J., Feng M., Jian J., Zhang X.,
RA Luo G., Jiang Y., Liu J., Wang Z., Sha Y., Zhang B., Wu H., Tang D.,
RA Shen Q., Xue P., Zou S., Wang X., Liu X., Wang F., Yang Y., An X., Dong Z.,
RA Zhang K., Zhang X., Luo M.C., Dvorak J., Tong Y., Wang J., Yang H., Li Z.,
RA Wang D., Zhang A., Wang J.;
RT "Draft genome of the wheat A-genome progenitor Triticum urartu.";
RL Nature 496:87-90(2013).
RN [2] {ECO:0000313|EnsemblPlants:TuG1812S0002807600.01.T01}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (JUN-2022) to UniProtKB.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR AlphaFoldDB; A0A8R7RC45; -.
DR EnsemblPlants; TuG1812S0002807600.01.T01; TuG1812S0002807600.01.T01; TuG1812S0002807600.01.
DR Gramene; TuG1812S0002807600.01.T01; TuG1812S0002807600.01.T01; TuG1812S0002807600.01.
DR Proteomes; UP000015106; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-ARBA.
DR GO; GO:0002758; P:innate immune response-activating signaling pathway; IEA:UniProtKB-ARBA.
DR GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-ARBA.
DR FunFam; 1.10.10.10:FF:000322; Probable disease resistance protein At1g63360; 1.
DR FunFam; 1.10.8.430:FF:000003; Probable disease resistance protein At5g66910; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR057135; At4g27190-like_LRR.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR056789; LRR_R13L1-DRL21.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR058922; WHD_DRP.
DR PANTHER; PTHR36766:SF64; OS12G0206100 PROTEIN; 1.
DR PANTHER; PTHR36766; PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8; 1.
DR Pfam; PF25019; LRR_R13L1-DRL21; 1.
DR Pfam; PF23247; LRR_RPS2; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR Pfam; PF23559; WHD_DRP; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000015106};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 17..90
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 171..338
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT DOMAIN 422..502
FT /note="Disease resistance protein winged helix"
FT /evidence="ECO:0000259|Pfam:PF23559"
FT DOMAIN 690..820
FT /note="R13L1/DRL21-like LRR repeat region"
FT /evidence="ECO:0000259|Pfam:PF25019"
FT DOMAIN 974..1121
FT /note="Disease resistance protein At4g27190-like leucine-
FT rich repeats"
FT /evidence="ECO:0000259|Pfam:PF23247"
SQ SEQUENCE 1149 AA; 130945 MW; 3F652A59509EE2F9 CRC64;
MAESLLFPLV RGVAGKAADA LCGLDDDRQT LERRLLAVEC KLANAEEMSE TNRYVKSWMK
ELKSVAYEAD DVLDDFQYKA LWCQSNIGKS TTCKVLSYVT RHSPLLFRFE MSRKLKNVLK
KINKLVEEMN TLGLESSVRR EERQYPLRQT YSKLADTKEI FGRDHAKKVV VKLLLDQQDQ
WKVQVLPIFG MGGLGKTTLA KMVYNDEEVH DHFQLKMWHC VSENFDVIAL LKSIIELATN
GSSAMPGSIE QLQKKLDEVI GQQRFLLVLD DVWNEDKRMW EDELKPLLCT VGGPGSVIVV
TCRSKQVASI MSTVKPHELV FLCKEDSWEL FSNKAFCNGI EQQAELATIG RRIVDKCGGL
PLALKAMGGL LSSKQNVQEW KAIEESNIGD NDGGKYEIMP ILKLSYKHLS SEMKQCFAFC
AVFPKDYQME KDRLIQLWMA NGFIQEDGTM DLTQKGELIF NELFWRSFLQ DKKVVLKSTA
YGGEPRYETI VCKMHDLMHD LAKVVTDECA TIEELTRQKE LLKYVCHMKI SKAKFEEISG
LCKSKTYLHT LLAPSESWKD NHYKFPSRYK DIKELAHVLA SLRALCCSPS PIVICKAIKS
KHLRYLDLSE SNIVVLPDSI CMLYNLQTLR LIDCKELRQL SEDMIGLKML IHLYLFGCDR
LKSMSPNFGL LNNLHILTTF VVDSKDGRGI EQLKDLQHLS NKLELLNLSK IKSGGNAKEA
NLNQKKNLSE LLFSWDQEID DGPQNMAYNV EEVLHSLEPH SNIQKLEIRG YGGREISQWM
RKPQMLNYLR ELKISDCPTC KSIPTVWLSL SLEILSVQKM DNLTTLCNNN IDVESECITP
LQIFPRLKRM MLIELPNLEI WAENSVRKPC DSLVMFPMVE ELRIENCPKL VSIPVTPIVS
EMTIVGVHST AVSLVFMSIR LGSWPFLARL TLGYPEDIPM LLLDTQQSES QMPIEKLVSL
TLEGPNSLVR SLGWSRSKLI VWKCFPFVED LTISRCNDLV SWPTEELRCL DRLRVLRIKD
CDNLEGNTSL SEEETVPLSL EKLWIASCPN MMGLPSNLGN LTKLTTLSVF SCISLKVLPD
GMRGLTSLRN MTIWHCPAME EFPHGLLERL PALEHLSLYG CPELERRCGE GGEYFHLLSS
IPHKSIAEY
//
