ID A0A8S1H4W8_9PELO Unreviewed; 851 AA.
AC A0A8S1H4W8;
DT 12-OCT-2022, integrated into UniProtKB/TrEMBL.
DT 12-OCT-2022, sequence version 1.
DT 18-JUN-2025, entry version 10.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN ORFNames=CAUJ_LOCUS6414 {ECO:0000313|EMBL:CAD6190495.1};
OS Caenorhabditis auriculariae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=2777116 {ECO:0000313|EMBL:CAD6190495.1, ECO:0000313|Proteomes:UP000835052};
RN [1] {ECO:0000313|EMBL:CAD6190495.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NKZ352 {ECO:0000313|EMBL:CAD6190495.1};
RA Kikuchi T.;
RL Submitted (OCT-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the RBR family. RNF19 subfamily.
CC {ECO:0000256|ARBA:ARBA00061087}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CAD6190495.1}.
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DR EMBL; CAJGYM010000016; CAD6190495.1; -; Genomic_DNA.
DR OrthoDB; 1431934at2759; -.
DR Proteomes; UP000835052; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd20338; BRcat_RBR_RNF19; 1.
DR CDD; cd20355; Rcat_RBR_RNF19; 1.
DR FunFam; 1.20.120.1750:FF:000001; RBR-type E3 ubiquitin transferase; 1.
DR FunFam; 2.20.25.20:FF:000004; RBR-type E3 ubiquitin transferase; 1.
DR FunFam; 3.30.40.10:FF:000424; RBR-type E3 ubiquitin transferase; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 2.20.25.20; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR031127; E3_UB_ligase_RBR.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR Pfam; PF01485; IBR; 2.
DR SMART; SM00647; IBR; 2.
DR SMART; SM00184; RING; 2.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000835052};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 411..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 465..495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 176..401
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 180..227
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 45..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 677..705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 777..851
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..160
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..701
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 822..833
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 851 AA; 92046 MW; 88D731C208505F4F CRC64;
MSSGKPSVGL GPLVECSEGV DPEDLNDTRA EHVMAERSRA IEDFRMRVRE TPSKSGEGAT
SRRKKTGSRL SLVSLFSFTS SGGAAARERS RSGWSYGEEG AGTVTMSSVS ASDIRVAVAG
SMNSNKRYRG SDAGSCADGG SDHVAESLLA GEEETADEPL SEGQTVPKKK STKAGKTREC
PLCCMTQSYA NFPRLLGCQH RSCRLCLMQY VELEIMENRV EISCPECPAF LHPQDIKKLV
GYRNGLIDKY EQFSIRRYLL SEPEARWCPA PDCGYAVIAS SCAACPQLKC ERDGCGMLFC
YHCKREWHAN QTCDEARRTR GGAGISSLRS GRRITSSSID AQLKPGDVKA CPRCRTFIVK
MDDGSCNHMV CAMCSAEFCW LCLKEISDLH YLSPTGCTFW GKKPWTRKKK LLWQLGTLIG
APAGIAFIAA LSVPGIIFGV PVFVGRKVHQ RFIHQSKWRR RILTAACFAG ALFVSPVLAI
MAVGVGVPIM LAYVYGVVPL SLCRNGGCGL SRSNSQAQFD SLDEEQLWSG SPGTDLSQLL
HEERQAMEVV SLDPTNSMHS GFSSAEARGQ GSLLVVTADV NRRRPSLESA VNSIEEKVNY
EEASVKAMAG SHYYDDKSIH TLYSGHEAVS YTDEIASTKA LAGSVIETKS LSESVGRHIL
ARHADKSEEE HVFLCVSPSS TGDKKGDEQT PCSSSSGGSA TRNKHYGVNR CQNADDFLLA
SEEGLLEISG ASRGTNHSAF GGPGHGNEIE PDPFKIHALL DSMKQMVAAD VPLEKSYEPT
PLRPTGKLRR SGSGKSMLAI GSPGILPSPV GMSHASMPPP SNSDNISTAG SSSSKRRRHL
GFFTSLFSRK K
//
