ID A0A8S3Z0G0_9EUPU Unreviewed; 680 AA.
AC A0A8S3Z0G0;
DT 12-OCT-2022, integrated into UniProtKB/TrEMBL.
DT 12-OCT-2022, sequence version 1.
DT 28-JAN-2026, entry version 11.
DE RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
DE Flags: Fragment;
GN ORFNames=CUNI_LOCUS5644 {ECO:0000313|EMBL:CAG5120086.1};
OS Candidula unifasciata.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Eupulmonata; Stylommatophora;
OC Helicina; Helicoidea; Geomitridae; Candidula.
OX NCBI_TaxID=100452 {ECO:0000313|EMBL:CAG5120086.1, ECO:0000313|Proteomes:UP000678393};
RN [1] {ECO:0000313|EMBL:CAG5120086.1}
RP NUCLEOTIDE SEQUENCE.
RG Molecular Ecology Group;
RL Submitted (APR-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Key enzyme in the cholesterol biosynthesis pathway. Catalyzes
CC the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that
CC forms the sterol nucleus. Through the production of lanosterol may
CC regulate lens protein aggregation and increase transparency.
CC {ECO:0000256|ARBA:ARBA00055567}.
CC -!- PATHWAY: Terpene metabolism; lanosterol biosynthesis; lanosterol from
CC farnesyl diphosphate: step 3/3. {ECO:0000256|ARBA:ARBA00060682}.
CC -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CAG5120086.1}.
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DR EMBL; CAJHNH020000830; CAG5120086.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A8S3Z0G0; -.
DR OrthoDB; 21502at2759; -.
DR Proteomes; UP000678393; Unassembled WGS sequence.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0000250; F:lanosterol synthase activity; IEA:TreeGrafter.
DR GO; GO:0006695; P:cholesterol biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR FunFam; 1.50.10.20:FF:000002; Terpene cyclase/mutase family member; 1.
DR FunFam; 1.50.10.20:FF:000003; Terpene cyclase/mutase family member; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR002365; Terpene_synthase_CS.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU362003};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000678393};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Steroid biosynthesis {ECO:0000256|ARBA:ARBA00022955}.
FT DOMAIN 23..264
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 333..668
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CAG5120086.1"
SQ SEQUENCE 680 AA; 77700 MW; 394181CFECD27152 CRC64;
SEEAPELPKA ENVPDAAKNG MSFYTKLQAE DGHWAGDYGG PLFLMPGLII VCYITKTPFT
QAQKLEMVRY LRSVMCPDGG WGLHIEGPPT VFGCTLNYCA MRILGVQADD ADLVKTRTLL
HKLGGAAAIP SWGKFWLSVL NVYSYDGLNS LFPEMWILPS WLPFHPSKLW CHCRQVYLPM
AYCFGRRIIA PEDDLIVQLR KEIFVEDYKN INWPSQRNNV SSADLYTPHS WLLDLSYFFL
NIYEKVHIGF IRKKALSVMY DHIAADDRFT KCISIGPVLK IGFLFQISKV INMLIRYHEE
GPLCKDFKLH QDRIQDFLWL GLDGMKMTGT NGSQMWDTAF AVHAFIEAGA YKSEEFRPSL
MAAYEFLRLT QIPENFPDYQ KYYRQMSEGG FPFSTRDCGW IVSDCTAEGI KAIVKLHEKC
FVNNPIKKEK LFRGIDVLLD MRCDDNGWAT YENKRGGKLL EMLNASEVFG DIMIDYTYVE
CTSACMQCLA SFTKSYPEYR QQEIKVALRE GLKYISNKQR PDGSWEGSWG VCFTYGAWFA
LEAYSCMGYT YDSGEEVPDE IKRGCEFLLD KQMEDGGWGE NFESCEIREY VNSETSQVVN
TCWAVLGLLA VNYPDVEVIE KGVQVIMSRQ LPNGDWPQEN ISGVFNKSCA ISYTSYRNIF
PIWALGRFAS MHPESLLVKS
//
