ID A0A8T0BB36_SILME Unreviewed; 388 AA.
AC A0A8T0BB36;
DT 12-OCT-2022, integrated into UniProtKB/TrEMBL.
DT 12-OCT-2022, sequence version 1.
DT 28-JAN-2026, entry version 11.
DE RecName: Full=Suppressor of cytokine signaling 4 {ECO:0008006|Google:ProtNLM};
GN ORFNames=HF521_021151 {ECO:0000313|EMBL:KAF7704079.1};
OS Silurus meridionalis (Southern catfish) (Silurus soldatovi meridionalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Siluridae; Silurus.
OX NCBI_TaxID=175797 {ECO:0000313|EMBL:KAF7704079.1, ECO:0000313|Proteomes:UP000606274};
RN [1] {ECO:0000313|EMBL:KAF7704079.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SWU-2019-XX {ECO:0000313|EMBL:KAF7704079.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:KAF7704079.1};
RA Zhang Y., Wang D., Peng Z.;
RT "Chromosome-level assembly of Southern catfish (Silurus meridionalis)
RT provides insights into visual adaptation to the nocturnal and benthic
RT lifestyles.";
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF7704079.1}.
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DR EMBL; JABFDY010000008; KAF7704079.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A8T0BB36; -.
DR OrthoDB; 8820570at2759; -.
DR Proteomes; UP000606274; Unassembled WGS sequence.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF35; SUPPRESSOR OF CYTOKINE SIGNALING 4 ISOFORM X1; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000606274};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 242..337
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 332..381
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 107..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..13
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..45
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..124
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 388 AA; 44596 MW; AC430A3A4996BFAC CRC64;
MSEKKSRPSD ARPKNLRSWS VDSYIRSVKK RSRGPRHDAP PRGVEDGDVP DEQNVRSTSC
PQRRRERKCS CTAIGDGDID SVCRKALSRR SLRQKFQDAV GQCLPLRGHH HHHHHHHHHH
HHHQGGSSRP FSVLLWSKRK IHVSELMEDK CPFSPKSELA QCWHLIKKHG THQNASIVLE
DHKSRRLTSS SSTFISWEEV SSNGASSLTD WDASFIHGAP QCYSHADCIL VPDLLQIINS
PCYWGVLNRF EAEQLLEGQP EGTFLLRDSA QDDYLFSVSF RRYSRSLHAR IEQSGKRFSF
DCRDPCMYRD VSITGLLKHY SDPATCLFFE PLLSRPLPRT FPFSLQHLCR ALICSCTTYQ
GIETLPLPHT LRDYLRLYHF KCDGACEI
//
