ID A0A8T2JJZ1_9PIPI Unreviewed; 535 AA.
AC A0A8T2JJZ1;
DT 12-OCT-2022, integrated into UniProtKB/TrEMBL.
DT 12-OCT-2022, sequence version 1.
DT 28-JAN-2026, entry version 9.
DE RecName: Full=Suppressor of cytokine signaling 5 {ECO:0008006|Google:ProtNLM};
GN ORFNames=GDO86_008984 {ECO:0000313|EMBL:KAG8443640.1};
OS Hymenochirus boettgeri (Congo dwarf clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Pipinae; Hymenochirus.
OX NCBI_TaxID=247094 {ECO:0000313|EMBL:KAG8443640.1, ECO:0000313|Proteomes:UP000812440};
RN [1] {ECO:0000313|EMBL:KAG8443640.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Female2 {ECO:0000313|EMBL:KAG8443640.1};
RC TISSUE=Blood {ECO:0000313|EMBL:KAG8443640.1};
RA Mudd A.B.;
RT "Comparative Genomics and Chromosome Evolution.";
RL Thesis (2020), ProQuest LLC, 789 East Eisenhower Parkway, Ann Arbor, MI,
RL USA.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAG8443640.1}.
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DR EMBL; JAACNH010000004; KAG8443640.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A8T2JJZ1; -.
DR OrthoDB; 8820570at2759; -.
DR Proteomes; UP000812440; Chromosome 5.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000812440};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 380..475
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 470..519
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 95..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 535 AA; 60742 MW; 955E068B6FECDED8 CRC64;
MDNVGKMWNT FKYRCQNLFN HENDGGPADS VDVNANRCMR AIDKNENAAG QSAILSIGPL
QPNITSGLSP SNSSSRTNQN CVTEMPQLVE ISVEKDNDSD LSSGTRLARR DSYTRHAPWG
GKKKHTCSTK TQNSFETDKK ICRGRTSLQR RERRHGSSSI HDMEAASGRA VGSRSIRQKL
NETVGLCFPI RTYNRPSKPL FTNKRKIHLS ELMLEKCPFP AGSDLAQKWH LIKQHTAPVS
PHSSILDTVD QTLISTEDEE DRLRERRRLS IEEGVDPPPN AQIHTFEATA QVNPAYKLGP
KLAPGMADMA GDTSAVSQAA CESEEDTTTL CLQSRRQKQR QFSGDSHTQP SKQGAWKVHT
QIDYIHCLVP DLIEITSNPC YWGVMDRYEA EALLEGRPEG TFLLRDSAQE DYLFSVSFRR
YNRSLHARIE QWNHNFSFDA HDPCVFHSST VTGLLEHYKD PSSCMFFEPL LTVPLNRTFP
FSLQYICRAV ICRSTTYDGI DLLPLPSMLQ DFLKEYHYKQ KVRVRWLERE PVKSK
//
