ID A0A8T2K3S8_9PIPI Unreviewed; 427 AA.
AC A0A8T2K3S8;
DT 12-OCT-2022, integrated into UniProtKB/TrEMBL.
DT 12-OCT-2022, sequence version 1.
DT 28-JAN-2026, entry version 8.
DE RecName: Full=Suppressor of cytokine signaling 4 {ECO:0008006|Google:ProtNLM};
GN ORFNames=GDO86_016037 {ECO:0000313|EMBL:KAG8449216.1};
OS Hymenochirus boettgeri (Congo dwarf clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Pipinae; Hymenochirus.
OX NCBI_TaxID=247094 {ECO:0000313|EMBL:KAG8449216.1, ECO:0000313|Proteomes:UP000812440};
RN [1] {ECO:0000313|EMBL:KAG8449216.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Female2 {ECO:0000313|EMBL:KAG8449216.1};
RC TISSUE=Blood {ECO:0000313|EMBL:KAG8449216.1};
RA Mudd A.B.;
RT "Comparative Genomics and Chromosome Evolution.";
RL Thesis (2020), ProQuest LLC, 789 East Eisenhower Parkway, Ann Arbor, MI,
RL USA.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAG8449216.1}.
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DR EMBL; JAACNH010000003; KAG8449216.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A8T2K3S8; -.
DR OrthoDB; 8820570at2759; -.
DR Proteomes; UP000812440; Chromosome 8_10.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF21; SUPPRESSOR OF CYTOKINE SIGNALING 4; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000812440};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 275..370
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 365..414
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 153..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..188
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 427 AA; 48859 MW; CB62B6218D2D1911 CRC64;
MAENIEEKLG ELEVKPKSSR SRSADRKDGY VWSGKKLSWL SKSGHSSDGD TINVEEKQAC
LAQCQKRKYS FSSVEFDFDR SCGHKMLGRS LKQKLQDAVG QCFPIKACSS RHSSALSSKR
KIHISELMLD KCPFPPKSDL AYRWHLIKRH TAPVSQTKEE QTIGGSSELD SKEMPLKDHD
SDAREDSLSD RQATACEINL CTVESLTSRS SKEESDIDSD DEVITLCTSS RKRNKPKWEI
DDEVFQAETP PKYHTQIDYV HCLVPDLFQI NNNPCYWGVM DRYAAEALLE GKPEGTFLLR
DSAQEDYLFS VSFRRYSRSL HARIEQWNHN FSFDAHDPCV FHAPNVTGLL EHYKDPSSCM
FFEPLLSSPL NRSFPFTLQH ICRSVICSCT NYDGIDALPV PSSLKLYLKE YHYKSKVRVR
RLDVPEQ
//
